Cytoprotective function of keratinocyte growth factor in tumour therapy-induced tissue damage

British Journal of Haematology

Volumn 116, Issue 3, 2002, Pages 505-510

  Wirth, Karin ^a   Mertelsmann, Roland ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

Clinical trial; Keratinocyte growth factor; Preclinical trial; Review; Tumour

Indexed keywords

AMYLASE; CARMUSTINE; CYTARABINE; ETOPOSIDE; FIBROBLAST GROWTH FACTOR; FLUOROURACIL; FOLINIC ACID; KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR RECEPTOR; MELPHALAN; METHOTREXATE; TRIACYLGLYCEROL LIPASE;

BONE MARROW TRANSPLANTATION; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL PROTECTION; CELL SURVIVAL; CLINICAL TRIAL; COLORECTAL CANCER; DOSE RESPONSE; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG SAFETY; DRUG TOLERANCE; EPITHELIUM CELL; GRAFT VERSUS HOST REACTION; GROWTH INHIBITION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KNOCKOUT MOUSE; LYMPHOMA; MESENCHYME CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; TISSUE INJURY; TRANSGENIC ANIMAL; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; HUMANS; MICE; RADIATION INJURIES;

EID: 0036183105     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0007-1048.2001.03290.x     Document Type: Review

References (51)

1. Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity
2. Fibroblast growth factor receptors: Lessons from the genes
3. Androgen receptor activation in prostatic tumour cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor
4. A phase I study of recombinant human keratinocyte growth factor (rHuKGF) in lymphoma patients receiving high-dose chemotherapy (HDC) with autologous peripheral blood progenitor cell transplantation (autoPBPCT)
5. Keratinocyte growth factor promotes healing of left-sided colon anastomoses
6. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality
7. Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice
8. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth
9. The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene
10. Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor
11. Intravenous keratinocyte growth factor protects against experimental pulmonary injury
12. Keratinocyte growth factor is required for hair development but not for wound healing
13. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease rationale for the use of cytokine shields in allogeneic bone marrow transplantation
14. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract
15. Preferential expression of the third immunoglobulin-like domain of K-sam product provides keratinocyte growth factor dependent growth in carcinoma cell lines
16. Keratinocyte growth factor as a mitogen for primary culture of rat hepatocytes
17. Fibroblast growth factor receptor tyrosine kinases: Molecular analysis and signal transduction
18. Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor
19. Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice
20. Cytokine cascades in acute graft-versus-host disease
21. Keratinocyte growth factor separates graft-versus-leukaemia effects from graft-versus-host disease
22. Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin
23. Keratinocyte growth factor (KGF) as a mucositis protectant: A randomised phase I trial
24. Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop
25. Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene
26. Protection from thymic epithelial cell (TEC) injury by pre-BMT keratinocyte growth factor (KGF): A new approach to speed thymic reconstitution after lethal irradiation
27. Expression of keratinocyte growth factor in embryonic liver of transgenic mice causes changes in epithelial growth and differentiation resulting in polycystic kidneys and other organ malformations
28. Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo
29. Fibroblast growth factors
30. Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice
31. Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury
32. Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung
33. Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor
34. FGF7/KGF triggers cell transformation and invasion on immortalised human prostatic epithelial PNT1A cells
35. Purification and characterisation of a newly identified growth factor specific for epithelial cells
36. Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro
37. Safety, pharmacokinetics and biologic activity of rHuKGF in normal volunteers: Results of a placebo-controlled randomised double-blind phase I study
38. Fibroblast growth factor receptors display both common and distinct signaling pathways
39. Increased expression of keratinocyte growth factor in human pancreatic cancer
40. Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung
41. Human keratinocyte growth factor effects in a porcine model of epidermal wound healing
42. KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells
43. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo
44. Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative haemorrhagic cystitis
45. Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer
46. Large induction of keratinocyte growth factor expression in the dermis during wound healing
47. The function of KGF in morphogenesis of epithelium and reepithelalization of wounds
48. Functions of fibroblast growth factors and their receptors
49. Keratinocyte growth factor causes proliferation of urothelium in vivo
50. Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality
51. Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats