Acetaminophen cytotoxicity in mouse eye: Mitochondria in anterior tissues are the primary target

Journal of Ocular Pharmacology and Therapeutics

Volumn 13, Issue 3, 1997, Pages 269-276

  Zhao, Cong ^a   Xiong, Ye ^a   Shichi, Hitoshi ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA NAPHTHOFLAVONE; CORN OIL; PARACETAMOL; SODIUM CHLORIDE;

ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE SEGMENT; CILIARY BODY EPITHELIUM; CONFERENCE PAPER; CONTROLLED STUDY; CORNEA ENDOTHELIUM; DRUG TARGETING; ENERGY METABOLISM; EYE TOXICITY; INTRAPERITONEAL DRUG ADMINISTRATION; IRIS; LENS; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PIGMENT EPITHELIUM; RETINA NEUROEPITHELIAL LAYER;

EID: 0031001171     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1997.13.269     Document Type: Conference Paper

References (25)

1. Koneru, P.B., Lien, E.J. and Koda, R.T. Review: Oculotoxicities of systemically administered drugs. J. Ocular Pharmacol. 2:385-404, 1986.
2. Shichi, H., Gaasterland, D.E., Jensen, N.M. and Nebert, D.W. The Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen. Science 200:539-541, 1978.
3. Boelsterli, U.A. Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury. Drug Met. Rev. 25:395-451, 1993.
4. Holtzman, J.L. The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen. Drug Met. Rev. 27:277-297, 1995.
5. Dahlin, D.C., Miwa, G.T., Liu, A.Y.H. and Nelson, S.D. N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. U.S.A. 81:1327-1331, 1984.
6. Patten, C.J., Thomas, P.E., Guy, R.L., Lee, M., Gonzalez, F.J., Guengerich, F.P. and Yang, C.S. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem. Res. Toxicol. 6:511-518, 1993.
7. Raucy, J.L., Lasker, J.M., Lieber, C.S. and Black, M. Acetaminophen activation by human liver cytochromes P450 2E 1 and P450 1A2. Arch. Biochem. Biophys. 271:270-283, 1989.
8. Thummel, K.E., Lee, C.A., Kunze, K.L., Nelson, S.D. and Slattery, J.T. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP 3A4. Biochem. Pharmacol. 45:1563-1569, 1993.
9. Lubek, B.M., Avaria, M., Basu, P.K. and Wells, P.G. Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. Fundam. Appl. Toxicol. 10:596-606, 1988.
10. Shichi, H., Tanaka, M., Jensen, N.M. and Nebert, D.W. Genetic deferences in cataract and other ocular abnormalities induced by paracetamol and naphthalene. Pharmacology 20:229-241, 1980.
11. Zhao, C. and Shichi, H. Mechanism of acetaminophen cytotoxicity in mouse eye. Invest Ophthalmol. Vis. Sci. 37:S580, 1996.
12. Zhao, C. and Shichi, H. Historical study on the possible mechanism of acetaminophen cataractogenesis in mouse eye. Exp. Mol. Pathol. in press, 1996.
13. Sciamanna, M.A., Zinkel, J., Fabi, A.Y. and Lee, C.P. Ischemic mjury to rat forebrain mitochondria and cellular calcium homeostasis. Biochem. Biophys. Acta. 1134:223-232, 1992.
14. Nicholls, D.G. Bioenergetics. Academic Press, New York, 1982.
15. Dixon, M.F., Dixon, B., Aparicio, S.R. and Loney, D.P. Experimental paracetamol -induced hepatic necrosis: A light-and electron-microscope, and histochemical study. J. Pathol. 116:17-29, 1975.
16. Walker, R.M., Racz, W.J. and McElligott, T.F. Acetaminophen-induced hepatotoxicity in mice. Lab. Invest. 42:181-189, 1980.
17. Donnelly, P.J., Walker, R.M. and Racz, W.J. Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity. Arch. Toxicol. 68:110-118, 1994.
18. Esterline, R.L., Ray, S.D. and Ji, S. Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinone mune (NAPQI). Biochem. Pharmacol. 38:2387-2390, 1989.
19. Andersson, B.S., Rundgren, M., Nelson, S.D. and Harder, S. N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes. Chem.-Biol. Interactions 75:201-211, 1990.
20. Burcham, P.C. and Harman, A.W. Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J. Biol. Chem. 266:5049-5054, 1991.
21. Friedman, E., Smith, T.R. and Mimura-Oak, S. Estimation of retinal blood flow in animals. Invest. Ophthalmol. 4:1122-1128, 1965.
22. Davson, H. Physiology of the Eye, Academic Press, New York, 1980.
23. Mitchell, J.R., Jollow, D.J., Potter, W.Z., Gillette, J.R. and Brodie, B.B. Acetaminophen induced hepatic necrosis. IV. Possible protective role of glutathione. J. Pharmacol. Exp. Ther. 187:211-217, 1973.
24. Lubek, B.M., Basu, P.K. and Wells, P.G. Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains. Toxicol Appl. Pharmacol. 94:485-495, 1988.
25. Rathbun, W.B., Holleschau, A.M., Cohen, J.F. and Nagasawa, H.T. Prevention of acetaminophen-and naphthalene-induced cataract and glutathione loss by CySSME. Invest. Ophthalmol. Vis. Sci. 37:923-929, 1996.