Recombinant monoclonal antibody technology

Transfusion Clinique et Biologique

Volumn 9, Issue 1, 2002, Pages 15-22

  Siegel, D L ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Blood group antigen; Immunoglobulin gene; Monoclonal antibody; Phage display; Rh immune globulin

Indexed keywords

BLOOD GROUP ANTIGEN; COMPLEMENTARY DNA; FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; REAGENT; RECOMBINANT ANTIBODY; RHESUS D ANTIBODY;

ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BLOOD BANK; CONFERENCE PAPER; GENE EXPRESSION; HUMAN; HYBRIDOMA; IMMUNIZATION; IMMUNOGLOBULIN GENE; IMMUNOMODULATION; LYMPHOCYTE TRANSFORMATION; NEWBORN HEMOLYTIC DISEASE; NONHUMAN; PHAGE DISPLAY; POLYMERASE CHAIN REACTION; THROMBOCYTOPENIA;

EID: 0036181477     PISSN: 12467820     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1246-7820(01)00210-5     Document Type: Conference Paper

References (40)

1. Continuous cultures of fused cells secreting antibody of predefined specificity
2. Man-made antibodies
3. Making antibodies by phage display technology
4. Creating and engineering human antibodies for immunotherapy
5. Phage libraries - A new route to clinically useful antibodies
6. New approaches to monoclonal antibody production
7. Introduction to antibody engineering and phage display
8. Research and clinical applications of antibody phage display in transfusion medicine
9. Isolation of cell surface-specific human monoclonal antibodies using phage display and magnetically-activated cell sorting: Applications in immunohematology
10. Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: Implications for Rh(D) epitope topology
11. Sequence and specificity analysis of recombinant human Fab anti-Rh D isolated by phage display
12. CHO expression of a novel human recombinant IgG1 anti-RhD antibody isolated by phage display
13. Isolation of an IgG anti-B from a human Fab-phage display library
14. A human monoclonal antibody specific for the leucine-33 (P1A1, HPA-la) form of platelet glycoprotein IIIa from a V gene phage display library
15. Production of large repertories of macaque mAbs to human RBCs using phage display
16. Human antibody fragments specific for human blood group antigens from a phage display library
17. Characterization of human blood group scFv antibodies derived from a V gene phage-display library
18. H gene segments rearranged in vitro
19. Construction of a human Ig combinatorial library from genomic V segments and synthetic CDR3 fragments
20. Antibody fragments from a "single pot" phage display library as immunochemical reagents
21. Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions
22. Synthesis of Rh Fv phage-antibodies using VH and VL germline genes
23. Expression and characterization of recombinant anti-Rh(D) antibodies on filamentous phage: A model system for isolating human red blood cell antibodies by repertoire cloning
24. Only selected light chains combine with a given heavy chain to confer specificity for a model glycopeptide antigen
25. A molecular approach for isolating high-affinity Fab fragments that are useful in blood group serology
26. Epitope migration: Anti-Rh(D) antibodies as a model for human immunogenicity
27. Construction of mono- and bivalent human single-chain Fv fragments against the D antigen in the Rh blood group: Multimerization effect on cell agglutination and application to blood typing
28. A recombinant human scFv anti-Rh(D) antibody with multiple valences using a C-terminal fragment of C4-binding protein
29. Rapid phenotyping of HPA-1a using either diabody-based hemagglutination or recombinant IgG1-based assays
30. pFab-CMV, a single vector system for the rapid conversion of recombinant Fabs into whole IgG1 antibodies
31. Human Rh D monoclonal antibodies (BRAD-3 and BRAD-5) cause accelerated clearance of Rh D+ red blood cells and suppression of Rh D immunization in Rh D-volunteers
32. Isolation of human IgG platelet autoantibodies using phage display
33. Genetic origin of IgG antibodies cloned by phage display and anti-idiotypic panning from three patients with autoimmune thrombocytopenia
34. Platelet-reactive IgG antibodies cloned by phage display and panning with IVIG from three patients with autoimmune thrombocytopenia
35. Recombinant human IgG molecules lacking Fcgamma receptor I binding and monocyte triggering activities
36. Requirements for the establishment of heterohybridomas secreting monoclonal human antibody to rhesus (D) blood group antigen
37. Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies
38. Searching peptide ligands with an epitope library