Introduction to antibody engineering and phage display

Vox Sanguinis

Volumn 78, Issue 2, 2000, Pages 72-79

  Watkins, Nicholas A ^a   Ouwehand, Willem H ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; ALEMTUZUMAB; CHIMERIC ANTIBODY; MESSENGER RNA; MONOCLONAL ANTIBODY; REAGENT; RITUXIMAB;

ANTIBODY PRODUCTION; B LYMPHOCYTE; CELL IMMORTALIZATION; DRUG DESIGN; GENE LIBRARY; HUMAN; IMMUNOGENICITY; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

EID: 0034020978     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1159/000031154     Document Type: Review

References (56)

1. Kohler G, Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-497.
2. Scott ML, Voak D: Monoclonal antibodies to human red cell blood group antigens, in Garratty G (ed): Immunobiology of Transfusion Medicine. New York, Dekker, 1994, pp 365-385.
3. Boylston AW, Gardner B, Anderson RL, Hughes-Jones NC: Production of human IgM anti-D in tissue culture by EB-virus- transformed lymphocytes. Scand J Immunol 1980;12:355-358.
4. Thompson KM, Melamed MD, Eagle K, Gorick BD, Gibson T, Holburn AM, Hughes Jones NC: Production of human monoclonal IgG and IgM antibodies with anti-D (rhesus) specificity using heterohybridomas. Immunology 1986;58:157-160.
5. Melamed MD, Thompson KM, Gibson T, Hughes-Jones NC: Requirements for the establishment of heterohybridomas secreting monoclonal human antibody to rhesus (D) blood group antigen. J Immunol Methods 1987;104: 245-251.
6. Thompson KM, Hough DW, Maddison PJ, Melamed MD, Hughes-Jones N: The efficient production of stable, human monoclonal antibody-secreting hybridomas from EBV-transformed lymphocytes using the mouse myeloma X63-Ag8.653 as a fusion partner. J Immunol Methods 1986;94:7-12.
7. Boulianne GL, Hozumi N, Shulman MJ: Production of functional chimaeric mouse/human antibody. Nature 1984;312:643-646.
8. Leget GA, Czuczman MS: Use of rituximab, the new FDA-approved antibody. Curr Opin Oncol 1998;10:548-551.
9. Califf RM, Lincoff AM, Tcheng JE, Topol EJ: An overview of the results of the EPIC trial. Eur Heart J 1995;16(suppl L):43-49.
10. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. The EPIC Investigation. N Engl J Med 1994;330:956-961.
11. Jones PT, Dear PH, Foote J, Neuberger MS, Winter G: Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 1986;321:522-525.
12. Riechmann L, Clark M, Waldmann H, Winter G: Reshaping human antibodies for therapy. Nature 1988;332:323-327.
13. Verhoeyen M, Milstein C, Winter G: Reshaping human antibodies: Grafting an antilysozyme activity. Science 1988;239:1534-1536.
14. Alzari PM, Spinelli S, Mariuzza RA, Boulot G, Poljak RJ, Jarvis JM, Milstein C: Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: The role of somatic mutation and heavy/light chain pairing in the maturation of an immune response. EMBO J 1990;9:3807-3814.
15. Amit AG, Mariuzza RA, Phillips SE, Poljak RJ: Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution. Science 1986;233:747-753.
16. Poljak RJ, Amzel LM, Avey HP, Chen BL, Phizackerley RP, Saul F: Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2.8-Å resolution. Proc Natl Acad Sci U S A 1973;70:3305-3310.
17. Hale G, Dyer MJ, Clark MR, Phillips JM, Marcus R, Riechmann L, Winter G, Waldmann H: Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet 1988;ii:1394-1399.
18. Isaacs JD, Watts RA, Hazleman BL, Hale G, Keogan MT, Cobbold SP, Waldmann H: Humanised monoclonal antibody therapy for rheumatoid arthritis. Lancet 1992;340:748-752.
19. Mathieson PW, Cobbold SP, Hale G, Clark MR, Oliveira DB, Lockwood CM, Waldmann H: Monoclonal-antibody therapy in systemic vasculitis. N Engl J Med 1990;323:250-254.
20. Kang AS, Barbas CF, Janda KD, Benkovic SJ, Lerner RA: Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc Natl Acad Sci U S A 1991;88:4363-4366.
21. Barbas CF 3d, Kang AS, Lerner RA, Benkovic SJ: Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci USA 1991;88:7978-7982.
22. McCafferty J, Griffiths AD, Winter G, Chiswell DJ: Phage antibodies: Filamentous phage displaying antibody variable domains. Nature 1990;348:552-554.
23. Smith GP: Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface. Science 1985;228:1315-1317.
24. Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR: Making antibodies by phage display technology. Annu Rev Immunol 1994;12: 433-455.
25. Clackson T, Hoogenboom HR, Griffiths AD, Winter G: Making antibody fragments using phage display libraries. Nature 1991;352:624-628.
26. Huston JS, Levinson D, Mudgett-Hunter M, Tai MS, Novotny J, Margolies MN, Ridge RJ, Bruccoleri RE, Haber E, Crea R et al: Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 1988; 85:5879-5883.
27. Hoogenboom HR, Griffiths AD, Johnson KS, Chiswell DJ, Hudson P, Winter G: Multi-subunit proteins on the surface of filamentous phage: Methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res 1991;19:4133-4137.
28. Orlandi R, Gussow DH, Jones PT, Winter G: Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc Natl Acad Sci U S A 1989;86:3833-3837.
29. Cook GP, Tomlinson IM: The human immunoglobulin VH repertoire, Immunol Today 1995;16:237-242.
30. Huse WD, Sastry L, Iverson SA, Kang AS, Alting-Mees M, Burton DR, Benkovic SJ, Lerner RA: Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 1989;246:1275-1281.
31. Waterhouse P, Griffiths AD, Johnson KS, Winter G: Combinatorial infection and in vivo recombination: A strategy for making large phage antibody repertoires. Nucleic Acids Res 1993;21:2265-2266.
32. Marks JD, Hoogenboom HR, Bonnert TP, McCafferty J, Griffiths AD, Winter G: By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol 1991; 222:581-597.
33. Marks JD, Ouwehand WH, Bye JM, Finnern R, Gorick BD, Voak D, Thorpe SJ, Hughes Jones NC, Winter G: Human antibody fragments specific for human blood group antigens from a phage display library. Biotechnology N Y 1993;11:1145-1149.
34. Hughes Jones NC, Gorick BD, Bye JM, Finnern R, Scott ML, Voak D, Marks JD, Ouwehand WH: Characterization of human blood group scFv antibodies derived from a V gene phage-display library. Br J Haematol 1994;88:180-186.
35. Finnern R, Bye JM, Dolman KM, Zhao MH, Short A, Marks JD, Lockwood MC, Ouwehand WH: Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries. Clin Exp Immunol 1995;102: 566-574.
36. Griffin HM, Ouwehand WH: A human monoclonal antibody specific for the leucine-33 (P1A1, HFA-1a) form of platelet glycoprotein IIIa from a V gene phage display library. Blood 1995;86:4430-4436.
37. Davies J, van der Brink EN, Baglin TP, Voornerg J, Allain J-P, Ouwehand WH: Primary structure of the variable domains of factor VIII antibodies obtained from inhibitor patient B cell RNA by V gene phage display technology. Thromb Haemost 1997;575.
38. Nissim A, Hoogenboom HR, Tomlinson IM, Flynn G, Midgley C, Lane D, Winter G: Antibody fragments from a 'single pot' phage display library as immunochemical reagents. EMBO J 1994;13:692-698.
39. Hughes-Jones NC, Bye JM, Gorick BD, Marks JD, Ouwehand WH: Synthesis of Rh Fv phage-antibodies using VH and VL germline genes. Br J Haematol 1999;105:811-816.
40. Hoogenboom HR, Winter G: By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro. J Mol Biol 1992;227:381-388.
41. Griffiths AD, Williams SC, Hartley O, Tomlinson IM, Waterhouse P, Crosby WL, Kontermann RE, Jones PT, Low NM, Allison TJ, et al: Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J 1994;13:3245-3260.
42. Hawkins RE, Russell SJ, Winter G: Selection of phage antibodies by binding affinity. Mimicking affinity maturation. J Mol Biol 1992; 226:889-896.
43. Pistillo MP, Hammer J, Bono E, Sinigaglia F, Bottero F, Gho A, Ferrara GB: A novel approach to human anti-HLA mABs production: use of phage display libraries. Hum Immunol 1997;57:19-26.
44. de Kruif J, Terstappen L, Boel E, Logtenberg T: Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library. Proc Natl Acad Sci U S A 1995;92:3938-3942.
45. Kupsch JM, Tidman NH, Kang NV, Truman H, Hamilton S, Patel N, Newton Bishop JA, Leigh IM, Crowe JS: Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells. Clin Cancer Res 1999;5:925-931.
46. Pelsers MM, Lutgerink JT, Nieuwenhoven FA, Tandon NN, van der Vusse GJ, Arends JW, Hoogenboom HR, Glatz JF: A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: Abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up- regulation in diabetes. Biochem J 1999;337:407-414.
47. Osbourn JK, Derbyshire EJ, Vaughan TJ, Field AW, Johnson KS: Pathfinder selection: In situ isolation of novel antibodies, Immunotechnology 1998;3:293-302.
48. Sawyer C, Embleton J, Dean C: Methodology for selection of human antibodies to membrane proteins from a phage-display library. J Immunol Methods 1997;204:193-203.
49. Siegel DL, Chang TY, Russell SL, Bunya VY: Isolation of cell surface-specific human monoclonal antibodies using phage display and magnetically-activated cell sorting: Applications in immunohematology. J Immunol Methods 1997;206:73-85.
50. Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I: A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature 1989;339:394-397.
51. Holliger P, Prospero T, Winter G: 'Diabodies': Small bivalent and hispecific antibody fragments. Proc Natl Acad Sci USA 1993;90: 6444-6448.
52. Williamson LM, Hackett G, Rennie J, Palmer CR, Maciver C, Hadfield R, Hughes D, Jobson S, Ouwehand WH: The natural history of feto-maternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening. Blood 1998;92: 2280-2287.
53. Watkins NA, Armour KL, Smethurst PA, Metcalfe P, Scott ML, Hughes DL, Smith GA, Williamson LM, Clark MR, Ouwehand WH: Rapid phenotyping of HPA-1a using either diabody-based hemagglutination or recombinant IgG1-based assays. Transfusion 1999;39:781-789.
54. Garner SF, Smethurst PA, Merieux Y, Achy C, Armour KL, Scott ML, Williamson LM, Metcalfe P, Goodall AH, Clark MR, Rigal D, Schawaller M, Ouwehand WH: A rapid one stage whole blood HPA-1a phenotyping assay using a recombinant monoclonal IgG1 anti-HPA-1a. Br J Haematol, in press.
55. Armour KL, Clark MR, Hadley AG, Williamson LM: Human IgG molecules lacking FegRI binding and monocyte triggering activities. Eur J Immunol. 1999;29:2613-2624.
56. Watkins NA, Brown C, Hurd C, Navarrete C, Ouwehand WH: The isolation and characterisation of human monoclonal HLA-A2 antibodies from an immune V gene phage display library. Tissue Antigens, in press.