Modulation of matrix metalloproteinase-1, its tissue inhibitor, and nuclear factor-κB by losartan in hypercholesterolemic rabbits

Journal of Cardiovascular Pharmacology

Volumn 39, Issue 3, 2002, Pages 332-339

  Chen, Hongjiang ^a   Li, Dayuan ^a   Mehta, Jawahar L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Angiotensin II; Aorta; Hypercholesterolemia; Lipid deposition; Losartan

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; DRUG VEHICLE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; LOSARTAN; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY INTIMA; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL DIET; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; ARTERIOSCLEROSIS; BLOTTING, WESTERN; CHOLESTEROL; DIET, ATHEROGENIC; GENE EXPRESSION REGULATION; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; LOSARTAN; MALE; MATRIX METALLOPROTEINASE 1; NF-KAPPA B; RABBITS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TUNICA INTIMA; TUNICA MEDIA;

EID: 0036180776     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200203000-00003     Document Type: Article

References (43)

1. Endothelin-1 and angiotensin-II stimulate delayed mitogenesis in cultured rat aortic smooth muscle cells: Evidence for common signaling mechanisms
2. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells
3. Role of angiotensin in the control of vascular smooth muscle cell growth
4. Multiple autocrine growth factors modulate vascular smooth muscle cell response to angiotensin II
5. Cell biology and genetics of angiotensin in cardiovascular disease
6. The stimulation of human neutrophil migration by angiotensin: Its dependence on Ca2+ and the involvement of cyclic GMP
7. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: Contribution to alterations of vasomotor tone
8. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type I receptor activation
9. Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappa B in human monocytes
10. The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation
11. Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of anti-atherosclerotic effect of vitamin E, lovastatin and amlodipine
12. Technics for studying atherosclerotic lesions
13. Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits
14. Effects of TH-142177 on angiotensin II-induced proliferation, migration and intracellular signaling in vascular smooth muscle cells and on neointimal thickening after balloon injury
15. The angiotensin-II receptor antagonist, losartan, inhibits LDL lipid peroxidation and atherosclerosis in apolipoprotein E-deficient mice
16. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
17. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis
18. Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis: Implications for plaque rupture
19. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques
20. Expression of collagen, interstitial collagenase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy
21. Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 from the aortas of cholesterol fed rabbits partially counterbalances increased metalloproteinase activity
22. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion
23. Single step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extration
24. High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells: Demonstration of ligand-induced downregulation of expressed receptor mRNA and protein
25. Gamma-tocopherol decreases ox-LDL-mediated activation of nuclear factor-κB and apoptosis in human coronary artery endothelial cells
26. Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells
27. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: A potential mechanism of lesion stabilization
28. Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 from the aortas of cholesterol fed rabbits partially counterbalances increased metalloproteinase activity
29. Angiotensin-converting enzyme inhibitor prevents arterial nuclear factor-κB activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis
30. Oxidized low density lipoprotein induces activation of the transcription factor NFκB in fibroblasts, endothelial and smooth muscle cells
31. Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: Potential implications for inflammation and plaque instability
32. Induction of chymase that forms angiotensin II in the monkey atherosclerotic aorta
33. Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression
34. Upregulation of vascular angiotensin II receptor gene expression by low density lipoproteins in vascular smooth muscle cells
35. Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation
36. Beta-blockade prevents sustained metalloproteinase activation and diastolic stiffening induced by angiotensin II combined with evolving cardiac dysfunction
37. Angiotensin II induces TIMP-1 production in rat heart endothelial cells
38. Hormonal regulation of cardiac fibroblast function
39. Angiotensin II induces nuclear factor-kappa B activation in cultured neonatal rat cardiomyocytes through protein kinase C signaling pathway
40. Angiotensin II activates nuclear transcription factor kappaB through AT(1) and AT(2) in vascular smooth muscle cells: Molecular mechanisms
41. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress
42. Effect of angiotensin II receptor blocker on angiotensin II stimulated DNA synthesis of cultured human aortic smooth muscle cells
43. Angiotensin-converting enzyme inhibitors and atherosclerosis: Relevance of animal models to human disease