Shigella flexneri interactions with the basolateral membrane domain of polarized model intestinal epithelium: Role of lipopolysaccharide in cell invasion and in activation of the mitogen-activated protein kinase ERK

Infection and Immunity

Volumn 70, Issue 3, 2002, Pages 1150-1158

  Köhler, Henrik ^a   Rodrigues, Sonia P ^a   McCormick, Beth A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BACTERIUM ADHERENCE; BASOLATERAL MEMBRANE; CELL INVASION; CELL POLARITY; CELL SPREADING; COLON MUCOSA; ENZYME ACTIVATION; INTERNALIZATION; INTESTINE EPITHELIUM; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SHIGELLA FLEXNERI; SHIGELLOSIS; STRAIN DIFFERENCE;

CELL POLARITY; CELLS, CULTURED; ENZYME INHIBITORS; FLAVONOIDS; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; NEUTROPHILS; SHIGELLA FLEXNERI; SIGNAL TRANSDUCTION;

EID: 0036178763     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.3.1150-1158.2002     Document Type: Article

References (57)

1. Cytoskeletal rearrangements and the functional role of T-plastin during entry of Shigella flexneri into HeLa cells
2. Toll-like receptors in the induction of innate immune response
3. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
4. Potentially lethal complications of shigellosis
5. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors
6. Activation of ERK1/2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin-8
7. The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells
8. Pseudomonas pyocyanin increases interleukin-8 expression by human airway epithelial cells
9. Lack of cleavage of IcsA in Shigella flexneri causes aberrant movement and allows demonstration of a cross-reactive eukaryotic protein
10. Interferon alpha inhibits a Src-mediated pathway necessary for Shigella-induced cytoskeletal rearrangements in epithelial cells
11. Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: A connection between bacterial dissemination and neutrophil transepithelial signaling
12. Experimental Shigella infections: Characteristics of a fatal infection produced in guinea pigs
13. Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization
14. Salmonella typhimurium induces epithelial IL-8 expression via Ca (2+)- mediated activation of the NF-kappaB pathway
15. Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response
16. Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory genes expression
17. CARD4/NOD1 mediates NF-κB and JNK activation by invasive Shigella flexneri
18. Shigella subversion of the cellular cytoskeleton: A strategy for epithelial colonization
19. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
20. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
21. Stimulation of human neutrophils by soluble and insoluble immunoglobulin aggregates
22. Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells
23. Effect of mutations in Shigella flexneri chromosomal and plasmid-encoded lipolysaccharide genes on invasion and resistance
24. Rhodobacter sphaeroides diphosphotyl lipid A inhibits interleukin-6 production in CD14-negative murine marrow stromal cells stimulated with lipopolysaccharide or Paclitaxel
25. Activation of NF-kappaB via a src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells
26. Cl-secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue
27. Occluding junction structure-function relationships in a cultured monolayer
28. Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins
29. Ultrastructural pathology of the rectal mucosa in Shigella dysentery
30. Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils
31. Salmonella typhimurium attachment to human intestinal epithelial monolayers: Transcellular signalling to subepithelial neutrophils
32. Inhibition of Shigella flexneri-induced transepithelial migration of polymerphonuclear leukocytes by cadaverine
33. Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium
34. Apical secretion of a pathogen-elicited epithelial chemoattractant activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium
35. Shigella enters human colonic Caco-2 epithelial cells through the basolateral pole
36. Effects of polymorphonuclear leukocyte transmigration on barrier function of cultured intestinal epithelial monolayers
37. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways
38. Neutrophil migration across a cultured intestinal epithelium: Dependence on a CD11b/CD18-mediated event and enhanced efficiency in the physiologic direction
39. Invasion and pathogenesis of Shigella infections
40. Polymorphonuclear leukocyte transmigration promotes invasion of colonic epithelial monolayer by Shigella flexneri
41. Invasive Shigella flexneri activates NF-κB through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells
42. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
43. Nontoxic RsDPLA as a potent antagonist of toxic lipopolysaccharide
44. Effect of O-side chain length and composition on the virulence of Shigella flexneri 2a
45. Avirulence of rough mutants of Shigella flexneri: Requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane
46. Microbes and microbial toxins: Paradigms for microbial-mucosal interactions. Ill. Shigellosis: From symptoms to molecular basis
47. Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis
48. A functional role for ezrin during Shigella flexneri entry into epithelial cells
49. CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells
50. Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen-activated protein kinase pathway
51. Stress fiber-based movement of Shigella flexneri within cells
52. Increasing complexity of the ras signaling pathway
53. P38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
54. Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cells
55. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
56. Localization of endotoxin in the rat intestinal epithelium
57. CD14: Cell surface receptor and differentiation marker