A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction

Biochemical Journal

Volumn 349, Issue 1, 2000, Pages 261-266

  Haan, Claude ^a   Hermanns, Heike M ^a   Heinrich, Peter C ^a   Behrmann, Iris ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Cytokine receptor; Interleukins; Jak STAT pathway; Janus kinase

Indexed keywords

ALANINE; CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 5 RECEPTOR; INTERLEUKIN 6; JANUS KINASE; STAT PROTEIN; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALANINE; ANIMALS; ANTIGENS, CD; B-LYMPHOCYTES; CELL DIVISION; COS CELLS; CYTOKINE RECEPTOR GP130; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-6; JANUS KINASE 1; MEMBRANE GLYCOPROTEINS; MICE; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-5; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TRYPTOPHAN;

ANIMALIA; CHIMAERIFORMES; JANUS;

EID: 0034235418     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3490261     Document Type: Article

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