Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris

International Immunopharmacology

Volumn 2, Issue 4, 2002, Pages 579-589

  Hasegawa, Takashi ^a   Matsuguchi, Tetsuya ^b   Noda, Kiyoshi ^a   Tanaka, Kuniaki ^a   Kumamoto, Shoichiro ^a   Shoyama, Yukihiro ^c   Yoshikai, Yasunobu ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Antitumor activity; Chlorella vulgaris; Gene knockout mice; Interleukin 12 (IL 12); Toll like receptors (TLRs)

Indexed keywords

CD14 ANTIGEN; GLYCOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; PROTEIN P40; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STIMULATION; CHLORELLA VULGARIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE; CHLORELLA; DROSOPHILA PROTEINS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; INTERLEUKIN-12; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SPLEEN; TIME FACTORS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0036175944     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(02)00002-4     Document Type: Article

References (49)

1. Chlorella accelerates dioxin excretion in rats
2. Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats
3. Effect of long-term administration of Chlorella tablets on hyperlipemia
4. Effect of γ-aminobutyric acid-rich Chlorella on blood pressure in mildly hypertensive subjects
5. Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris
6. Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): Resistance to Meth-A tumor growth mediated by CE-induced polymorphonuclear leukocytes
7. Oral administration of Chlorella vulgaris augments concomitant antitumor immunity
8. Augmentation of host defense by a unicellular green alga, Chlorella vulgaris, to Escherichia coli infection
9. Augmentation of the resistance against Escherichia coli by oral administration of a hot water extract of Chlorella vulgaris in rats
10. Augmentation of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice
11. Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses
12. Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections
13. Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice
14. Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes
15. A water-soluble antitumor glycoprotein from Chlorella vulgaris
16. A conserved signaling pathway: The Drosophila Toll-dorsal pathway
17. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
18. A Toll-like receptor recognizes bacterial DNA
19. Regulation of NF-κB activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester
20. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kB binding sites
21. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide
22. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages
23. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide
24. Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gandii antigens
25. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
26. Systems for polyacrylamide gel electrophoresis
27. Gene expressions of lipopolysaccharide receptors, toll-like receptor 2 and 4, are differently regulated in mouse T lymphocytes
28. In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse
29. Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts
30. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
31. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
32. A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation
33. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
34. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
35. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
36. The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
37. Dendric-cell function in Toll-like receptor- and MyD88-knockout mice
38. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
39. Lipid modification of bacterial prolipoprotein: Transfer of diacylglyceryl moiety from phosphatidylglycerol
40. Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
41. Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions
42. + T cells through IL-12 produced by Listeria-induced macrophages
43. + T cells
44. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts
45. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
46. Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo
47. Natural immunity: A T-cell-independent pathway of macrophage activation, defined in the SCID mouse
48. Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter: Demonstration of novel functional elements by a reductionist approach
49. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10