Increased sensitivity to nicotine-induced seizures in mice expressing the L250t α7 nicotinic acetylcholine receptor mutation

Molecular Pharmacology

Volumn 61, Issue 3, 2002, Pages 695-705

  Broide, Ron S ^a   Salas, R ^a   Ji, Daoyun ^a   Paylor, Richard ^a   Patrick, James W ^a   Dani, John A ^a   De Biasi, Mariella ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; EPIBATIDINE; IODINE 125; LEUCINE; MESSENGER RNA; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; THREONINE; TRITIUM;

AMINO ACID SUBSTITUTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN NERVE CELL; CONTROLLED STUDY; FEMALE; GENE MUTATION; HETEROZYGOTE; HIPPOCAMPUS; HOMOZYGOTE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR SENSITIVITY; TONIC CLONIC SEIZURE;

AMINO ACID SUBSTITUTION; ANIMALS; DIHYDRO-BETA-ERYTHROIDINE; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; FEMALE; GANGLIONIC STIMULANTS; HETEROZYGOTE; HIPPOCAMPUS; LYSINE; MALE; MICE; MICE, INBRED C57BL; NEUROANATOMY; NICOTINE; PHENOTYPE; RECEPTORS, NICOTINIC; SEIZURES; THREONINE;

EID: 0036175413     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.3.695     Document Type: Article

References (53)

1. Nicotinic acetylcholine receptors on hippocampal neurons: Distribution on the neuronal surface and modulation of receptor activity
2. Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus
3. Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices
4. Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain
5. Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy
6. Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists
7. Normal apoptosis levels in mice expressing one α7 nicotinic receptor null and one L250T mutant allele
8. Regulation of alpha7 nicotinic acetylcholine receptors in the developing rat somatosensory cortex by thalamocortical afferents
9. The alpha-bungarotoxin-binding nicotinicacetylcholine receptor from rat brain contains only the alpha7 subunlt
10. Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice
11. Pharmacological characterization of nicotine-induced seizures in mice
12. Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
13. Absence of α7 does not prevent nicotine-induced seizures
14. Strain-selective effects of nicotine on electrophysiological responses evoked in hippocampus from DBA/2Ibg and C3H/2Ibg mice
15. Hippocampal synaptic transmission enhanced by low concentration of nicotine
16. Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine
17. Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons
18. Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity
19. Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord
20. Attentional mediation of cigarette smoking's effect on anxiety
21. Mecamylamine but not the alpha7 receptor antagonist alpha-bungarotoxin blocks sensitization to the locomotor stimulant effects of nicotine
22. Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety
23. Local circuit interactions between oriens/alveus interneurons and CA1 pyramidal cells in hippocampal slices: Electrophysiology and morphology
24. Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion
25. Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra
26. Development of nicotinic drug therapy for cognitive disorders
27. Effect of ventral tegmental 6-hydroxydopamine lesions on the locomotor stimulant action of nicotine in rats
28. Nicotine increases thermogenesis in brown adipose tissue in rats
29. Sympathectomy inhibits the vasoactive effects of nicotine in conscious rats
30. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits
31. Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors
32. Relationship between nicotine-induced seizures and hippocampal nicotinic receptors
33. Classical genetic analysis of nicotine-induced seizures and nicotinic receptors
34. Nicotine enhances presynaptic and postsynaptic glutamatergic neurotransmission to activate cardiac parasympathetic neurons
35. Centrotemporal spikes in families with rolandic epilepsy: Linkage to chromosome 15q14
36. Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics
37. Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die witkin 1 day of birth
38. Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents
39. α7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: A behavioral characterization of Acra7-deficient mice
40. CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy
41. Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission
42. Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
43. Physiological and morphological identification of a nonpyramidal hippocampal cell type
44. Neuronal nicotinic receptors in human epilepsy
45. Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes
46. Potential role of the alpha4 and alpha6 nicotinic receptor subunits in regulating nicotine-induced seizures
47. Nicotine in an animal model of attention
48. Nicotine psychopharmacology: Addiction, cognition and neuroadaptation
49. Actions of nicotine upon the limbic system
50. Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats
51. 125I-α-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain
52. Presynaptic nicotinic receptors modulating dopamine release in the rat striatum
53. Identification of four classes of brain nicotinic receptors using beta2 mutant mice