Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 10, 1997, Pages 3373-3377

  Hegele, Robert A ^a,e   Connelly, Philip W ^a   Scherer, Stephen W ^b   Hanley, Anthony J G ^c   Harris, Stewart B ^d   Tsui, Lap Chee ^b   Zinman, Bernard ^c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e HEART AND STROKE FOUNDATION OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLESTERASE; GLUCOSE;

ADULT; ARTICLE; CHROMOSOME 7Q; DIET RESTRICTION; FEMALE; GENE MAPPING; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT;

ADOLESCENT; ADULT; ALLELES; ARYLDIALKYLPHOSPHATASE; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; ESTERASES; FASTING; FEMALE; GENE FREQUENCY; GENOTYPE; GLUCOSE INTOLERANCE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; REFERENCE VALUES; VARIATION (GENETICS);

EID: 0030983832     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.10.3373     Document Type: Article

References (21)

1. Elbein SC, Hoffman MD, Bragg KL, Mayorga RA. 1994 The genetics of NIDDM. Diabetes Care. 17:1523-1533.
2. Ghosh S, Schork NJ. 1996 Genetic analysis of NIDDM: the study of quantitative traits. Diabetes. 45:1-14.
3. Hanis CL, Boerwinkle E, Chakraborty R, et al. 1996 A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet. 13:161-166.
4. Mahtani MM, Widen E, Lento M, et al. 1996 Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet. 14:90-94.
5. Lander ES, Schork NJ. 1994 Genetics of complex traits. Science. 265:2037-2048.
6. Prochazka M, Thompson B, Scherer SW, et al. 1995 Linkage and association of insulin resistance and NIDDM with markers at 7q21.3-q22.1 in the Pima Indians. Diabetes. 45:42A.
7. Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong, CE. 1993 The molecular basis of the human serum plasma paraoxonase activity polymorphism. Nat Genet. 3:73-76.
8. Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN. 1996 The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics. 33:498-507.
9. Rowles J, Scherer SW, Xi T, et al. 1996 Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. J Biol Chem. 271:22376-22382.
10. Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE. 1996 The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat Genet. 14:334-336.
11. Baier LJ, Sacchettini JC, Knowler WC, et al. 1995 An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation and insulin resistance. J Clin Invest. 95:1281-1287.
12. Harris SB, Gittelsohn J, Hanley AJG, et al. 1997 The prevalence of NIDDM, and associated risk factors in native Canadians. Diabetes Care. 20:185-197.
13. WHO Expert Committee on Diabetes Mellitus. 1980 Second report. Geneva: WHO; Technical Report Series 646.
14. National Diabetes Data Group. 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
15. Hegele RA, Harris SB, Hanley AJG, Sadikian S, Connelly PW, Zinman B. 1996 Genetic variation in intestinal fatty acid binding protein associated with variation in body mass in aboriginal Canadians. J Clin Endocrinol Metab. 81:4334-4337.
16. Hegele RA, Brunt JH, Connelly PW. 1995 A polymorphism of the paraoxonase gene associated with variation in blood pressure in a genetic isolate. Arterioscler Thromb Vasc Biol. 15:89-95.
17. SAS Institute Inc. 1987 SAS/STAT guide for personal computers, version, 6th ed. Cary: SAS Institute.
18. Hegele RA, Brunt JH, Connelly PW. 1995 Multiple genetic determinants of variation of plasma lipoproteins in a genetic isolate. Arterioscler Thromb Vasc Biol. 15:861-871.
19. Kidd KK. 1993 Associations of disease with genetic markers: deja vu all over again. Am J Med Genet. 48:71-73.
20. Ruiz J, Blanche H, James RW, et al. 1995 Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Lancet. 346:869-872.
21. Serrato M, Marrian AJ. 1995 A variant of the human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease. J Clin Invest. 96:3005-3008.