Sphingosine kinase inhibitors in the apoptosis of leukaemia cells

Leukemia Research

Volumn 26, Issue 4, 2002, Pages 415-416

  Pallis, Monica ^a  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; ENZYME INHIBITOR; GLYCOPROTEIN P; N,N DIMETHYLSPHINGOSINE; N,N,N TRIMETHYLSPHINGOSINE; PROTEIN KINASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; CANCER INHIBITION; CELL GROWTH; CELL SURVIVAL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CYTOGENETICS; DRUG DELIVERY SYSTEM; DRUG POTENCY; ENZYME INHIBITION; HEMOLYSIS; LEUKEMIA CELL; METASTASIS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; ENZYME INHIBITORS; HUMANS; LEUKEMIA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOSINE;

EID: 0036170948     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00148-5     Document Type: Note

References (21)

1. Inhibited apoptosis and drug resistance in acute myeloid leukaemia
2. Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics
3. Killing cancer cells by poly-drug elevation of ceramide levels: A hypothesis whose time has come?
4. Sphingosine-1-phosphate: A prototype of a new class of second messengers
5. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
6. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
7. Functional roles of sphingosine, sphingosine-1-phosphate, and methylsphingosines: In regard to membrane sphingolipid signaling pathways
8. Cell membrane signaling as target in cancer therapy: Inhibitory effect of N,N-dimethyl and N,N,N-trimethylsphingosine derivatives on in vitro and in vivo growth of human tumour cells in nude mice
9. Cell membrane signaling as target in cancer therapy. II. Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumour cell-dependent platelet aggregation
10. Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: Cell membrane signaling as a target in cancer therapy III
11. In vitro and in vivo induction of apoptosis by sphingosine and N,N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells
12. Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
13. Effective cytotoxicity against human leukaemias and chemotherapy-resistant leukemia cells by N,N-dimethylsphingosine
14. Correlation of MDR1/P-170 expression with daunorubicin uptake and sensitivity of leukemic progenitors in acute myeloid leukemia
15. P-glycoprotein expression in patients with acute leukemia clinical relevance
16. Multidrug resistance gene expression in acute myeloid leukemia: Major prognosis significance for in vivo drug resistance to induction treatment
17. MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukaemia
18. Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A southwest oncology group study
19. Drug resistance factors in acute myeloid leukemia: A comparative analysis
20. P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway
21. TNF-alpha-induced sphingosine-1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes