Stimulation of cardiac apoptosis in essential hypertension potential role of angiotensin II

Hypertension

Volumn 39, Issue 1, 2002, Pages 75-80

  González, Arantxa ^a   López, Begoña ^a   Ravassa, Susana ^a   Querejeta, Ramón ^b   Larman, Mariano ^c   Díez, Javier ^a,d   Fortuño, María A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b Hospital Nuestra Senora de Aranzazu   (Spain)

^c Division of Hemodynamics   (Spain)

^d UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Amlodipine; Angiotensin II; Apoptosis; Heart; Hypertension, essential; Losartan

Indexed keywords

AMLODIPINE; ANGIOTENSIN; LOSARTAN;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; APOPTOSIS; ARTICLE; AUTOPSY; BLOOD PRESSURE REGULATION; CARDIOMYOPATHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ESSENTIAL HYPERTENSION; FEMALE; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HORMONE ACTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ISCHEMIC HEART DISEASE; MALE; NICK END LABELING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; AMLODIPINE; ANGIOTENSIN II; ANTIHYPERTENSIVE AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; FEMALE; HEART VENTRICLES; HUMANS; HYPERTENSION; LOSARTAN; MALE; MIDDLE AGED; MYOCARDIUM; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN;

EID: 0036155603     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/hy0102.100788     Document Type: Article

References (36)

1. Myocyte death and ventricular remodeling
2. Apoptosis in hypertensive heart disease
3. The molecular basis of apoptosis
4. Apoptosis. Cell death in tissue regulation
5. Apoptosis in target organs in hypertension
6. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat
7. Cardiomyocyte apoptosis and cardiac angiotensin-converting enzyme in spontaneously hypertensive rats
8. On the nature of cell death during remodeling of hypertrophied human myocardium
9. Apoptosis in pressure-overloadinduced heart hypertrophy in the rat
10. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro
11. 1 blockade with losartan
12. Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease
13. Increased serum concentrations of procollagen peptides in essential hypertension: Relation to cardiac alterations
14. Mechanisms of increased susceptibility to angiotensin II-induced apoptosis in ventricular cardiomyocytes of spontaneously hypertensive rats
15. The protooncogene Bcl-2 and its role in regulating apoptosis
16. Significance of myocytes with positive DNA end-labeling (TUNEL) in hearts with dilated cardiomyopathy
17. Muscle fiber orientation and connective tissue content in the hypertrophied human heart
18. Stretch-induced programmed myocyte cell death
19. Angiotensin II activates programmed myocyte cell death in vitro
20. Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell
21. Angiotensin II type 2 receptor mediates programmed cell death
22. Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression
23. Nifedipine does not induce but rather prevents apoptosis in cardiomyocytes
24. Apoptosis during regression of cardiac hypertrophy in spontaneously hypertensive rats. Temporal regulation and spatial heterogeneity
25. Effects of different dihydropyridine calcium antagonist on plasma norepinephrine in essential hypertension
26. Adrenergic regulation of myocardial apoptosis
27. Hypothesis. Apoptosis may be a mechanism for the transition to heart failure with chronic pressure overload
28. Myocyte cellular hypertrophy is responsible for ventricular remodelling in the hypertrophied heart of middle aged individuals in the absence of cardiac failure
29. Control of apoptosis of cardiovascular fibroblasts: A novel drug target
30. Susceptibility to apoptosis measured by MYC, BCL-2, and BAX expression in arterioles and capillaries of adult spontaneously hypertensive rats
31. Contribution of non-cardiomyocyte apoptosis to cardiac remodelling that occurs in the transition from compensated hypertrophy to heart failure in spontaneously hypertensive rats
32. Increased apoptosis in the heart of genetic hypertension, associated with increased fibroblasts
33. Evidence that human cardiac myocytes divide after myocardial infarction
34. 1 receptor subtype
35. Usefulness of serum carboxy-terminal propeptide of procollagen type I in assessment of the cardioreparative ability of antihypertensive treatment in hypertensive patients