Overexpression of Bax protein and enhanced apoptosis in the left ventricle of spontaneously hypertensive rats: Effects of AT1 blockade with losartan

Hypertension

Volumn 32, Issue 2, 1998, Pages 280-286

  Fortuño, María Antonia ^a   Ravassa, Susana ^a   Etayo, Juan Carlos ^a   Díez, Javier ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Angiotensin II; Apoptosis; Bax; Bcl 2; Losartan; Rats, inbred SHR

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; LOSARTAN; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DENSITY; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; GENE OVEREXPRESSION; HEART LEFT VENTRICLE; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 0031868854     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.32.2.280     Document Type: Article

References (41)

1. Bennett MR, Evan GI. The molecular basis of apoptosis. Heart Failure. 1994;9:199-212.
2. Wyllie AH. Apoptosis: cell death in tissue regulation. J Pathol. 1987; 153:313-316.
3. Reed JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol. 1994;124:1-6.
4. Hockenbery D, Nuñez G, Milliman C, Schreiber RD, Korsmeyer S. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature. 1990;348:334-336.
5. Oltvai Z, Milliman C, Schreiber RD, Korsmeyer S. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 1993;74:609-619.
6. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med. 1997;3:614-620.
7. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell. 1994;79:189-192.
8. Hamet P, Richard L, Dam TV, Teiger E, Orlov SN, Gaboury L, Gossard F, Tremblay J. Apoptosis in target organs in hypertension. Hypertension. 1995;26:642-648.
9. Díez J, Panizo A, Hernández M, Vega F, Sola I, Fortuño MA, Pardo J. Cardiomyocyte apoptosis and cardiac angiotensin-converting enzyme in spontaneously hypertensive rats. Hypertension. 1997;30:1029-1034.
10. Li Z, Bing OHL, Long X, Robinson KG, Lakatta EG, Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. Am J Physiol. 1997;272:H2313-H2319.
11. Teiger E, Dam TV, Richard L, Wisnewsky C, Tea BS, Gaboury L, Tremblay J, Schwanz K, Hamet P. Apoptosis in pressure-overload-induced heart hypertrophy in the rat. J Clin Invest. 1996;97:2891-2897.
12. Kajstura J, Cigola E, Malhotra A, Li P, Cheng W, Meggs LG, Anversa P. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol. 1997;29:859-870.
13. Cigola E, Kajstura J, Li B, Meggs LG, Anversa P. Angiotensin II activates programmed myocyte cell death in vitro. Exp Cell Res. 1997;231: 363-371.
14. Pierzchalski P, Reiss K, Cheng W, Cirielli C, Kajstura J, Nitahara JA, Rizk M, Capogrossi C, Anversa P. p53 induces myocyle apoptosis via activation of the renin-angiotensin system. Exp Cell Res. 1997;234: 57-65.
15. Lovenberg W. Techniques for the measurement of blood pressure. Hypertension. 1987;9(suppl I):I-5-I-6.
16. Olivetti G, Anversa P, Melissari M, Loud AV. Morphometry of medial hypertrophy in the rat thoracic aorta. Lab Invest. 1980;42:559-565.
17. Panizo A, Pardo J, Hernández M, Galindo MF, Cenarruzabeitia E, Díez J. Quinapril decreases myocardial accumulation of extracellular matrix components in spontaneously hypertensive rats. Am J Hypertens. 1995; 8:815-822.
18. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific binding of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
19. Itoh G, Tamura J, Suzuki M, Suzuki Y, Ikeda H, Koike M, Nomura M, Jie T, Ito K. DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. Am J Pathol. 1995;146:1325-1331.
20. Panizo-Samos A, Sola JJ, Pardo-Mindán FJ, Hernández M, Cenarruzabeitia E, Díez J. Angiotensin converting enzyme inhibition prevents polyploidization of cardiomyocytes in spontaneously hypertensive rats with left ventricular hypertrophy. J Pathol. 1995;177:431-437.
21. Cheng W, Li B, Kajstura J, Li P, Wolin MS, Sonnenblick EH, Hintze TH, Olivetti G, Anversa P. Stretch-induced programmed myocyte cell death. J Clin Invest 1995;96:2247-2259.
22. Díez J, Panizo A, Hernández M, Pardo J. Is the regulation of apoptosis altered in smooth muscle cells of adult spontaneously hypertensive rats? Hypertension. 1997;29:776-780.
23. Misao J, Hayakawa Y, Ohno M, Kato S, Fujiwara T, Fujiwara H. Expression of bcl-2 protein, an inhibitor of apoptosis, and bax, an accelerator of apoptosis, in ventricular myocytes of human beans with myocardial infarction. Circulation. 1996;94:1506-1512.
24. Kirshenbaum LA, de Moissac D. The bcl-2 gene product prevents programmed cell death of ventricular myocytes. Circulation. 1997;96: 1580-1585.
25. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Lieberman DA, Hoffman B, Reed JC. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994;9:1799-1805.
26. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 1995;80:293-299.
27. Kim KK, Soonpaa MH, Daud AI, Koh GI, Kim JS, Field LJ. Tumor suppressor gene expression during normal and pathologic myocardial growth. J Biol Chem. 1994;269:22607-22613.
28. Williams GT, Smith CA. Molecular regulation of apoptosis: genetic controls on cell death. Cell. 1993;74:777-779.
29. Meggs LG, Coupet J, Huang H, Cheng W, Li P, Capasso JM, Homcy CJ, Anversa P. Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats. Circ Res. 1993;72:1149-1162.
30. Brilla CG, Zhou G, Matsubara L, Weber KT. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol. 1994;26:809-820.
31. Hockenbery DM, Olltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 1993;75:241-251.
32. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science. 1993;262:1274-1277.
33. Liu Y, Cigola E, Cheng W, Kajstura J, Olivetti G, Hintze TH, Anversa P. Myocyte nuclear mitotic division and programmed cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs. Lab Invest. 1995;73:771-778.
34. Conrad CH, Brooks WW, Hayes JA, Sen S, Robinson KG, Bing OHL. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation. 1995;91:161-170.
35. Olivetti G, Melissari M, Balbi T, Quaini F, Cigola E, Sonnenblick EH, Anversa P. Myocyte cellular hypertrophy is responsible for ventricular remodelling in the hypertrophied heart of middle aged individuals in the absence of cardiac failure. Cardiovasc Res. 1994;28:1199-1208.
36. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw BA. Apoptosis in myocyte end-stage heart failure. N Engl J Med. 1996;335:1182-1189.
37. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, Di Loreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P. Apoptosis in the failing human heart. N Engl J Med. 1997;336:1131-1141.
38. Bing OHL. Hypothesis: apoptosis may be a mechanism for the transition to heart failure with chronic pressure overload. J Mol Cell Cardiol. 1994;26:943-948.
39. deBlois D, Tea BS, Dam TV, Tremblay J, Hamet P. Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats. Hypertension. 1997;29(pt 2):340-349.
40. Toger CA, Francis GS. Use of angiotensin-converting enzyme inhibitors in the treatment and prevention of congestive heart failure. In: Messerli FH, ed. Cardiovascular Drug Therapy. 2nd ed. Philadelphia, Pa: WB Saunders; 1996:711-717.
41. Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas Y, Deedwania PC, Ney DE, Snavely DB, Chang PI. Randomised trial of Iosartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet. 1997:349: 747-752.