Increased apoptosis in the heart of genetic hypertension, associated with increased fibroblasts

Cardiovascular Research

Volumn 45, Issue 3, 2000, Pages 729-735

  Liu, James J ^a   Peng, Liming ^a   Bradley, Christopher J ^a   Zulli, Anthony ^a   Shen, Jun ^a   Buxton, Brian F ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Angiotensin; Apoptosis; Extracellular matrix; Fibrosis; Hypertension; Myocytes

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DNA FRAGMENT; PROTEIN BAX; PROTEIN BCL 2; RAMIPRIL;

ADOLESCENT; AGED; AGING; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ULTRASTRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG EFFECT; ELECTRON MICROSCOPY; FIBROBLAST; HEART; HEREDITARY HYPERTENSION; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANALYSIS OF VARIANCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; DNA FRAGMENTATION; FIBROBLASTS; HEART; HYPERTENSION; MALE; MICROSCOPY, ELECTRON; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RAMIPRIL; RATS; RATS, INBRED WKY;

EID: 0033955803     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00382-X     Document Type: Article

References (13)

1. Kerr J.F.R., Wyllie A.H., Curie A.R. Apoptosis: basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
2. Kerr J.F.R., Winterford C.M., Harmon B.V. Apoptosis. Cancer. 73:1994;2013-2026.
3. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science. 267:1995;1456-1462.
4. Packer M. Paradigm shifts in heart failure: is apoptosis here to stay. Plenary session V - 70th scientific session. 1997;American Heart Association, Orlando, Florida, USA.
5. Ohno M., Takemura G., Ohno A., et al. 'Apoptotic' myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA. Fragmentation analysis by immunogold electron microscopy combined with in situ nick end-labeling. Circulation. 98:1998;1422-1430.
6. Buja L.M., Entman M.L. Modes of myocardial cell injury and cell death in ischemic heart disease. Circulation. 98:1998;1355-1357.
7. Johnston C.I. Renin-angiotensin system: a dual tissue and hormonal system for cardiovascular control. J. Hypertension. 10:(suppl 7):1992;S13-S26.
8. Peng L.M., Liu J.J. A novel method for quantitative analysis of apoptosis. Lab. Inv. 77:1997;547-555.
9. Bennett J.P., Yamamura H.I. Neurotransmitter, hormone, or drug receptor binding methods. Yamamura H.I. Neurotransmitter receptor binding. 2nd ed :1985;62-89 Raven Press.
10. Zulli A., Liu J.J. A noval immunohistochemical method for quantitation of nitric oxide synthase in human arteries. J. Histochem Cytochem. 46:1998;257-262.
11. Cigola E., Kajstura J., Li B., Meggs L.G., Anversa P. Angiotensin II activates programmed myocyte cell death in vitro. Exp Cell Res. 231:1997;363-371.
12. Anversa P., Palackal T., Sonnenblick E.H., et al. Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart. Circ. Res. 67:1990;871-885.
13. Brown R. The Bcl-2 family of proteins. Br Med. Bulletin. 53:1996;466-477.