메뉴 건너뛰기




Volumn 17, Issue 6, 1997, Pages 1898-1910

Inhibition of transmitter release correlates with the proteolytic activity of tetanus toxin and botulinus toxin A in individual cultured synapses of Hirudo medicinalis

Author keywords

botulinus toxin A; Hirudo medicinalis; single cell immunoblotting; SNAP 25; SNARE; synaptobrevin; tetanus toxin; transmitter release; VAMP

Indexed keywords

BOTULINUM TOXIN A; NEUROTRANSMITTER; SYNAPTOBREVIN;

EID: 0031016979     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-06-01898.1997     Document Type: Article
Times cited : (48)

References (62)
  • 1
    • 0025007115 scopus 로고
    • Structures and chromosomal locations of two human genes encoding synaptobrevins 1 and 2
    • Archer BT, Ozcelik T, Jahn R, Francke U, Südhof TC (1990) Structures and chromosomal locations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem 265:17267-17273.
    • (1990) J Biol Chem , vol.265 , pp. 17267-17273
    • Archer, B.T.1    Ozcelik, T.2    Jahn, R.3    Francke, U.4    Südhof, T.C.5
  • 3
    • 0028176426 scopus 로고
    • 2+-binding domain of clostridial neurotoxins restore exocytosis in chromaffin cells treated with tetanus or botulinus A neurotoxin
    • 2+-binding domain of clostridial neurotoxins restore exocytosis in chromaffin cells treated with tetanus or botulinus A neurotoxin. J Biol Chem 269:8122-8127.
    • (1994) J Biol Chem , vol.269 , pp. 8122-8127
    • Bartels, F.1    Bergel, H.2    Bigalke, H.3    Frevert, J.4    Halpern, J.5    Middlebrook, J.6
  • 4
    • 0026778460 scopus 로고
    • Syntaxin: A synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones
    • Bennett MK, Calakos N, Scheller RH (1992) Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science 257:255-259.
    • (1992) Science , vol.257 , pp. 255-259
    • Bennett, M.K.1    Calakos, N.2    Scheller, R.H.3
  • 7
    • 0027432376 scopus 로고
    • Botulinus neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin
    • Blasi J, Chapman ER, Yamasaki S, Binz T, Niemann H, Jahn R (1993b) Botulinus neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin. EMBO J 12:4821-4828.
    • (1993) EMBO J , vol.12 , pp. 4821-4828
    • Blasi, J.1    Chapman, E.R.2    Yamasaki, S.3    Binz, T.4    Niemann, H.5    Jahn, R.6
  • 8
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 10
    • 0028978441 scopus 로고
    • Real-time measurement of transmitter release from single synaptic vesicles
    • Bruns D, Jahn R (1995) Real-time measurement of transmitter release from single synaptic vesicles. Nature 377:62-65.
    • (1995) Nature , vol.377 , pp. 62-65
    • Bruns, D.1    Jahn, R.2
  • 11
    • 0027232238 scopus 로고
    • A fast activating presynaptic reuptake current during serotonergic transmission in identified neurons of Hirudo
    • Bruns D, Engert F, Lux HD (1993) A fast activating presynaptic reuptake current during serotonergic transmission in identified neurons of Hirudo. Neuron 10:559-572.
    • (1993) Neuron , vol.10 , pp. 559-572
    • Bruns, D.1    Engert, F.2    Lux, H.D.3
  • 12
    • 0030051050 scopus 로고    scopus 로고
    • Synaptic vesicle biogenesis, docking, and fusion: A molecular description
    • Calakos N, Scheller RH (1996) Synaptic vesicle biogenesis, docking, and fusion: a molecular description. Physiol Rev 76:1-29.
    • (1996) Physiol Rev , vol.76 , pp. 1-29
    • Calakos, N.1    Scheller, R.H.2
  • 13
    • 0027973132 scopus 로고
    • SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils
    • Chapman ER, An S, Barton N, Jahn R (1994) SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. J Biol Chem 269:27427-27432.
    • (1994) J Biol Chem , vol.269 , pp. 27427-27432
    • Chapman, E.R.1    An, S.2    Barton, N.3    Jahn, R.4
  • 14
    • 0000920828 scopus 로고
    • The packing of α-helices: Simple coiled-coils
    • Crick FHC (1953) The packing of α-helices: simple coiled-coils. Acta Crystallogr 6:689-697.
    • (1953) Acta Crystallogr , vol.6 , pp. 689-697
    • Crick, F.H.C.1
  • 16
    • 0022555595 scopus 로고
    • Voltage dependence of 5-hydroxytryptamine release at a synapse between identified leech neurons in culture
    • Lond
    • Dietzel ID, Drapeau P, Nicholls JG (1986) Voltage dependence of 5-hydroxytryptamine release at a synapse between identified leech neurons in culture. J Physiol (Lond) 372:191-205.
    • (1986) J Physiol , vol.372 , pp. 191-205
    • Dietzel, I.D.1    Drapeau, P.2    Nicholls, J.G.3
  • 17
    • 0024267221 scopus 로고
    • Selection of postsynaptic serotonin receptors during reinnervation of an identified leech neuron in culture
    • Drapeau P, Sanchez-Armass S (1988) Selection of postsynaptic serotonin receptors during reinnervation of an identified leech neuron in culture. J Neurosci 8:4718-4727.
    • (1988) J Neurosci , vol.8 , pp. 4718-4727
    • Drapeau, P.1    Sanchez-Armass, S.2
  • 18
    • 0028819440 scopus 로고
    • Synaptobrevin binding to synaptophysin: A potential mechanism for controlling the exocytotic fusion machine
    • Edelmann L, Hanson PI, Chapman ER, Jahn R (1995) Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. EMBO J 14:224-231.
    • (1995) EMBO J , vol.14 , pp. 224-231
    • Edelmann, L.1    Hanson, P.I.2    Chapman, E.R.3    Jahn, R.4
  • 19
    • 0024308501 scopus 로고
    • Two vesicle-associated membrane genes are differentially expressed in the rat central nervous system
    • Elferink LA, Trimble WS, Scheller RH (1989) Two vesicle-associated membrane genes are differentially expressed in the rat central nervous system. J Biol Chem 264:11061-11064.
    • (1989) J Biol Chem , vol.264 , pp. 11061-11064
    • Elferink, L.A.1    Trimble, W.S.2    Scheller, R.H.3
  • 20
    • 0028070987 scopus 로고
    • Vesicle fusion from yeast to man
    • Ferro-Novick S, Jahn R (1994) Vesicle fusion from yeast to man. Nature 370:191-193.
    • (1994) Nature , vol.370 , pp. 191-193
    • Ferro-Novick, S.1    Jahn, R.2
  • 21
    • 0029874232 scopus 로고    scopus 로고
    • Botulinus neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: Correlation with its blockade of catecholamine release
    • Foran P, Lawrence GW, Shone CC, Foster KA, Dolly JO (1996) Botulinus neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release. Biochemistry 35:2630-2636.
    • (1996) Biochemistry , vol.35 , pp. 2630-2636
    • Foran, P.1    Lawrence, G.W.2    Shone, C.C.3    Foster, K.A.4    Dolly, J.O.5
  • 22
    • 0020005027 scopus 로고
    • Chemical transmission between individual Retzius and sensory neurons of the leech in culture
    • Lond
    • Fuchs PA, Henderson LP, Nicholls JG (1982) Chemical transmission between individual Retzius and sensory neurons of the leech in culture. J Physiol (Lond) 323:195-210.
    • (1982) J Physiol , vol.323 , pp. 195-210
    • Fuchs, P.A.1    Henderson, L.P.2    Nicholls, J.G.3
  • 23
    • 0028130728 scopus 로고
    • Synaptic vesicle membrane fusion complex: Action of clostridial neurotoxins on assembly
    • Hayashi T, McMahon H, Yamasaki S, Binz T, Hata Y, Südhof TC, Niemann H (1994) Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. EMBO J 13:5051-5061.
    • (1994) EMBO J , vol.13 , pp. 5051-5061
    • Hayashi, T.1    McMahon, H.2    Yamasaki, S.3    Binz, T.4    Hata, Y.5    Südhof, T.C.6    Niemann, H.7
  • 24
    • 0026471991 scopus 로고
    • The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS
    • Hess DT, Slater TM, Wilson MC, Skene JHP (1992) The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS. J Neurosci 12:4634-4641.
    • (1992) J Neurosci , vol.12 , pp. 4634-4641
    • Hess, D.T.1    Slater, T.M.2    Wilson, M.C.3    Skene, J.H.P.4
  • 25
    • 0001823786 scopus 로고
    • Recombinant PCR
    • (Innis MA, Gelfand DH, Sinisky JJ, White TJ, eds). New York: Academic
    • Higuchi R (1990) Recombinant PCR. In: PCR protocols: a guide to methods and applications (Innis MA, Gelfand DH, Sinisky JJ, White TJ, eds), pp 177-183. New York: Academic.
    • (1990) PCR Protocols: A Guide to Methods and Applications , pp. 177-183
    • Higuchi, R.1
  • 27
    • 0344237032 scopus 로고
    • A 38,000 dalton membrane protein (p38) present in synaptic vesicles
    • Jahn R, Schiebler W, Ouimet C, Greengard P (1985) A 38,000 dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 82:1374-1388.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 1374-1388
    • Jahn, R.1    Schiebler, W.2    Ouimet, C.3    Greengard, P.4
  • 28
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 29
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 31
    • 0024563096 scopus 로고
    • Steps in the development of chemical and electrical synapses by pairs of identified leech neurons in culture
    • Liu Y, Nicholls J (1989) Steps in the development of chemical and electrical synapses by pairs of identified leech neurons in culture. Proc R Soc Lond [Biol] 236:253-268.
    • (1989) Proc R Soc Lond [Biol] , vol.236 , pp. 253-268
    • Liu, Y.1    Nicholls, J.2
  • 32
    • 0028241680 scopus 로고
    • Transmission at the squid giant synapse was blocked by tetanus toxin by affecting synaptobrevin, a vesicle-bound protein
    • Lond
    • Llinás R, Sugimori M, Morita M, Blasi J, Hereros J, Jahn R, Marsal J (1993) Transmission at the squid giant synapse was blocked by tetanus toxin by affecting synaptobrevin, a vesicle-bound protein. J Physiol (Lond) 477:129-133.
    • (1993) J Physiol , vol.477 , pp. 129-133
    • Llinás, R.1    Sugimori, M.2    Morita, M.3    Blasi, J.4    Hereros, J.5    Jahn, R.6    Marsal, J.7
  • 34
    • 0029980441 scopus 로고    scopus 로고
    • Sec18p (NSF)-driven release of Sec17p (α-SNAP) can precede docking and fusion of yeast vacuoles
    • Mayer A, Wickner W, Haas A (1996) Sec18p (NSF)-driven release of Sec17p (α-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85:83-94.
    • (1996) Cell , vol.85 , pp. 83-94
    • Mayer, A.1    Wickner, W.2    Haas, A.3
  • 35
    • 0024356962 scopus 로고
    • Light chain of tetanus toxin intracellularly inhibits acetylcholine release at neuro-neuronal synapses, and its internalization is mediated by heavy chain
    • Mochida S, Poulain B, Weller U, Habermann E, Taue L (1989) Light chain of tetanus toxin intracellularly inhibits acetylcholine release at neuro-neuronal synapses, and its internalization is mediated by heavy chain. FEBS Lett 253:47-51.
    • (1989) FEBS Lett , vol.253 , pp. 47-51
    • Mochida, S.1    Poulain, B.2    Weller, U.3    Habermann, E.4    Taue, L.5
  • 36
    • 0028310404 scopus 로고
    • Mechanism of action of tetanus and botulinus neurotoxins
    • Montecucco C, Schiavo G (1994) Mechanism of action of tetanus and botulinus neurotoxins. Mol Microbiol 13:1-8.
    • (1994) Mol Microbiol , vol.13 , pp. 1-8
    • Montecucco, C.1    Schiavo, G.2
  • 38
    • 0000712596 scopus 로고
    • Molecular biology of clostridial neurotoxins
    • (Alouf JE, Freer JE, eds). New York: Academic
    • Niemann H (1991) Molecular biology of clostridial neurotoxins. In: Source-book of bacterial toxins (Alouf JE, Freer JE, eds), pp 303-348. New York: Academic.
    • (1991) Source-book of Bacterial Toxins , pp. 303-348
    • Niemann, H.1
  • 39
    • 0028268948 scopus 로고
    • Clostridial neurotoxins: New tools for dissecting exocytosis
    • Niemann H, Blasi J, Jahn R (1994) Clostridial neurotoxins: new tools for dissecting exocytosis. Trends Neurosci 4:179-185.
    • (1994) Trends Neurosci , vol.4 , pp. 179-185
    • Niemann, H.1    Blasi, J.2    Jahn, R.3
  • 41
    • 0024828306 scopus 로고
    • Identification of a novel synaptosomal-associated protein SNAP-25, differentially expressed by neuronal subpopulations
    • Oyler GA, Higgins GA, Hart RA, Battenberg E, Billingsley M, Bloom FE, Wilson MC (1989) Identification of a novel synaptosomal-associated protein SNAP-25, differentially expressed by neuronal subpopulations. J Cell Biol 109:3039-3052.
    • (1989) J Cell Biol , vol.109 , pp. 3039-3052
    • Oyler, G.A.1    Higgins, G.A.2    Hart, R.A.3    Battenberg, E.4    Billingsley, M.5    Bloom, F.E.6    Wilson, M.C.7
  • 42
    • 0029118637 scopus 로고
    • Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion
    • Pelligrini LL, O'Connor V, Lottspeich F, Betz H (1995) Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion. EMBO J 14: 4705-4713.
    • (1995) EMBO J , vol.14 , pp. 4705-4713
    • Pelligrini, L.L.1    O'Connor, V.2    Lottspeich, F.3    Betz, H.4
  • 44
    • 0025676032 scopus 로고
    • Inhibition of neurotransmitter release by botulinus neurotoxins and tetanus toxin at Aplysia synapses: Role of constituent chains
    • Paris
    • Poulain B, Mochida S, Wadsworth JDF, Weller U, Habermann E, Dolly JO, Tauc L (1990) Inhibition of neurotransmitter release by botulinus neurotoxins and tetanus toxin at Aplysia synapses: role of constituent chains. J Physiol (Paris) 84:247-261.
    • (1990) J Physiol , vol.84 , pp. 247-261
    • Poulain, B.1    Mochida, S.2    Wadsworth, J.D.F.3    Weller, U.4    Habermann, E.5    Dolly, J.O.6    Tauc, L.7
  • 45
    • 0029929223 scopus 로고    scopus 로고
    • Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues
    • Ravichandran V, Chawla A, Roche PA (1996) Identification of a novel syntaxin-and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. J Biol Chem 271:13300-13303.
    • (1996) J Biol Chem , vol.271 , pp. 13300-13303
    • Ravichandran, V.1    Chawla, A.2    Roche, P.A.3
  • 47
    • 0029670289 scopus 로고    scopus 로고
    • Protein sorting by transport vesicles
    • Rothman JE, Wieland FT (1996) Protein sorting by transport vesicles. Science 272:227-234.
    • (1996) Science , vol.272 , pp. 227-234
    • Rothman, J.E.1    Wieland, F.T.2
  • 50
    • 0023472472 scopus 로고
    • Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
    • Schägger H, von Jagow G (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 166:368-379.
    • (1987) Anal Biochem , vol.166 , pp. 368-379
    • Schägger, H.1    Von Jagow, G.2
  • 54
    • 0027517462 scopus 로고
    • A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
    • Söllner T, Bennet MK, Whiteheart SW, Scheller RH, Rothman JE (1993b) A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell 75:409-418.
    • (1993) Cell , vol.75 , pp. 409-418
    • Söllner, T.1    Bennet, M.K.2    Whiteheart, S.W.3    Scheller, R.H.4    Rothman, J.E.5
  • 55
    • 0029026392 scopus 로고
    • The synaptic vesicle cycle: A cascade of protein-protein interactions
    • Südhof TC (1995) The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375:645-653.
    • (1995) Nature , vol.375 , pp. 645-653
    • Südhof, T.C.1
  • 56
    • 0024659539 scopus 로고
    • A synaptic vesicle membrane protein is conserved from mammals to Drosophila
    • Südhof TC, Baumert M, Perin MS, Jahn R (1989) A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Neuron 2:1475-1481.
    • (1989) Neuron , vol.2 , pp. 1475-1481
    • Südhof, T.C.1    Baumert, M.2    Perin, M.S.3    Jahn, R.4
  • 57
    • 0028815501 scopus 로고
    • Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
    • Sweeney ST, Broadie K, Keane J, Niemann H, O'Kane CJ (1995) Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron 14:341-351.
    • (1995) Neuron , vol.14 , pp. 341-351
    • Sweeney, S.T.1    Broadie, K.2    Keane, J.3    Niemann, H.4    O'Kane, C.J.5
  • 58
    • 0006602702 scopus 로고
    • VAMP-1: A synaptic vesicle-associated integral membrane protein
    • Trimble WS, Cowan DM, Scheller RH (1988) VAMP-1: a synaptic vesicle-associated integral membrane protein. Proc Natl Acad Sci USA 85:4538-4542.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4538-4542
    • Trimble, W.S.1    Cowan, D.M.2    Scheller, R.H.3
  • 59
    • 18244432240 scopus 로고    scopus 로고
    • Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25
    • Veit M, Söllner TH, Rothman JE (1996) Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25. FEBS Lett 385:119-123.
    • (1996) FEBS Lett , vol.385 , pp. 119-123
    • Veit, M.1    Söllner, T.H.2    Rothman, J.E.3
  • 60
    • 0028815453 scopus 로고
    • The t-SNARE syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling
    • Walch-Solimena C, Blasi J, Edelmann L, Chapman ER, Fischer von Mollard G, Jahn R (1995) The t-SNARE syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling. J Cell Biol 128:637-645.
    • (1995) J Cell Biol , vol.128 , pp. 637-645
    • Walch-Solimena, C.1    Blasi, J.2    Edelmann, L.3    Chapman, E.R.4    Fischer Von Mollard, G.5    Jahn, R.6
  • 62
    • 0028234762 scopus 로고
    • Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: Structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F
    • Yamasaki S, Hu Y, Binz T, Kalkuhl A, Kurazano H, Tamura T, Jahn R, Kandel E, Niemann H (1994) Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F. Proc Natl Acad Sci USA 91:4688-4692.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4688-4692
    • Yamasaki, S.1    Hu, Y.2    Binz, T.3    Kalkuhl, A.4    Kurazano, H.5    Tamura, T.6    Jahn, R.7    Kandel, E.8    Niemann, H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.