Inhibitors of ser/thr phosphatases 1 and 2A induce apoptosis in pituitary GH3 cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 1, 1997, Pages 8-16

  Tergau, Frithjof ^a   Weichert, Jan ^a   Quentin, Iris ^a   Opitz, Rüdiger ^a   Von Zezschwitz, Caroline ^a   Marwitz, John ^a   Ritz, Vera ^a   Steinfelder, Hans Jürgen ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Apoptosis; Calyculin A; Methyl okadaate; Okadaic acid; Okadaic acid tetraacetate; Pituitary cells; Ser thr phosphatase inhibitors

Indexed keywords

CALYCULIN A; DNA FRAGMENT; OKADAIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME INHIBITION; HYPOPHYSIS CELL; NONHUMAN; RAT;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; DNA FRAGMENTATION; ENZYME INHIBITORS; L-LACTATE DEHYDROGENASE; OKADAIC ACID; OXAZOLES; PHOSPHOPROTEIN PHOSPHATASE; PITUITARY GLAND; PLASMIDS; RATS; TRANSFECTION;

EID: 0030971727     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005032     Document Type: Article

References (62)

1. Andersen B, Rosenfeld MG (1994) Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis. J Biol Chem 269:29335-29338
2. Arends MJ, Morris RG, Wyllie AH (1990) Apoptosis - The role of the endonuclease. Am J Path 136:593-608
3. Barber SA, Salkowski CA, Fultz MJ, Perera PY, McNally R, Vogel SN (1996) Regulation of gene expression and nitric oxide production in murine macrophages by the serine/threonine phosphatase inhibitor okadaic acid. J Endotoxin Res 3:19-27
4. Berger J, Hauber J, Hauber R, Geiger R, Cullen BR (1988) Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene 66:1-10
5. Bergmeyer C (1983) Lactate dehydrogenase. In: Bergmeyer C (ed) Methods of enzymatic analysis. Verlag Chemie, Weinheim pp 171-172
6. Berridge MV, Tan AS, Hilton CJ (1993) Cyclic adenosine monophosphate promotes cell survival and retards apoptosis in a factor-dependent bone marrow-derived cell line. Exp Hematol 21:269-276
7. Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M (1988) The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell 55:505-518
8. Boe R, Gjertsen BT, Vintermyr OK, Houge G, Lanotte M, Doskeland SO (1991) The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 195:237-246
9. Burton K (1956) A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62:315-323
10. Cagnoli CM, Kharlamov E, Atabay C., Uz T, Manev H (1996) Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9. J Mol Neurosci 7:65-76
11. Cohen P (1989) The structure and regulation of protein phosphatases. Annu Rev Biochem 58:453-508
12. Cohen P, Klumpp S, Schelling DL (1989) An improved procedure for identifying and quantitating protein phosphatases in mammalian tissue. FEBS Lett 250:596-600
13. Colombel M, Olsson CA, Ng PY, Buttyan R (1992) Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res 52:4313-4319
14. Connor J, Sawczuk IS, Benson MC, Tomashefsky P, O'Toole KM, Olsson CA, Buttyan R (1988) Calcium channel antagonists delay regression of androgen-dependent tissues and suppress gene activity associated with cell death. Prostate 13:119-130
15. Cotter TG, Lennon SV, Glynn JG, Martin SJ (1990) Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells. Anticancer Res 10:1153-1160
16. Dana S, Karin M (1989) Induction of human growth hormone promoter activity by the adenosine 3′,5′-monophosphate pathway involves a novel responsive element. Mol Endocrinol 3:815-821
17. Fox SR, Jong MT, Casanova J, Ye ZS, Stanley F, Samuels HH (1990) The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters. Mol Endocrinol 4:1069-1080
18. 2+. Biochem Biophys Res Commun 181:915-920
19. Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiewicz (1993) The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 53:3186-3192
20. Hinkle PM, Tashjian AH (1973) Receptors for thyrotropin-releasing hormone in prolactin producing rat pituitary cells in culture. J Biol Chem 248:6180-6186
21. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336
22. Honkanen RE, Codispoti BA, Tse K, Boynton AL (1994) Characterization of natural toxins with inhibitory activity against serine/threonine protein phosphatases. Toxicon 32:339-350
23. Ishihara H, Martin BL, Brautigan DL, Karaki H, Ozaki H, Kato Y, Fusetani N, Watabe S, Hashimoto K, Uemura D, Hartshorne DJ (1989) Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity. Biochem Biophys Res Com 159:871-877
24. Kato Y, Fusetani N, Matsunaga S, Hashimoto K (1986) Calyculin A, a novel antitumor metabolite from the marine sponge Discoderma calyx. J Am Chem Soc 108:2780-2781
25. Kerr JFR, Harmon BV (1991) Definition and incidence of apoptosis: an historical perspective of cell death. In: Tomei LD, Cope FO (eds) Apoptosis - the molecular basis of cell death. Cold Spring Harbor Laboratory Press, pp 5-29
26. Kiguchi K, Glesne D, Chubb CH, Fujiki H, Huberman E (1994) Differential induction of apoptosis in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Cell Growth Differ 5:995-1004
27. 2+-dependent endonuclease as an early event in castration induced programmed cell death. Prostate 13:103-117
28. Li S, Crenshaw EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG (1990) Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1. Nature 347:528-533
29. 1 activity induced by doxorubicin in synchronized P388 cells. Mol Pharmacol 49:832-841
30. Lockshin RA, Zakeri Z (1991) Programmed cell death and apoptosis. In: Tomei LD, Cope FO (eds) Apoptosis - The molecular basis of cell death. Cold Spring Harbor Laboratory Press, New York pp 47-60
31. Maurer RA (1989) Both isoforms of the cAMP-dependent protein kinase catalytic subunit can activate transcription of the prolactin gene. J Biol Chem 264:6870-6873
32. McCormick A, Brady H, Theill LE, Karin M (1990) Regulation of the pituitary-specific homeobox gene GHFI by cell-autonomous and environmental cues. Nature 345:829-832
33. Morana SJ, Wolf CM, Li J, Reynolds JE, Brown MK, Eastman A (1996) The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification. DNA digestion, and apoptosis. J Biol Chem 271:18263-18271
34. Murata T, Shirakawa S, Takehara T, Kobayashi S, Haneji T (1995) Protein phosphatase inhibitors, okadaic acid and calyculin A, induce alkaline phosphatase activity in osteoblastic cells derived from newborn mouse calvaria. Biochem Mol Biol Int 36:365-372
35. Nelson C, Albert VR, Elsholtz HP, Lu LI, Rosenfeld MG (1988) Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor. Science 239:1400-1405
36. 2+-dependent mechanisms of cytotoxicity and programmed cell death. Tox Lett 64/65:357-364
37. Pastan I, Gottesman MM (1991) Multidrug resistance. Annu Rev Med 42:277-286
38. Paulson JR, Patzlaff JS, Vallis AJ (1996) Evidence that the endogenous histone H1 phosphatase in HeLa mitotic chromosomes is protein phosphatase 1, not protein phosphatase 2A. J Cell Sci 109:1437-1447
39. Radovick S, Nations M, Du Y, Berg LA, Weintraub BD, Wondisford FE (1992) A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. Science 257:1115-1118
40. Raff MC (1992) Social controls on cell survival and cell death. Nature 356:397-400
41. 2+-endonuclease and poly(ADP-ribose)polymerase inhibitors in mice. J Pharm Exp Ther 263:387-394
42. Richards GM (1974) Modifications of the diphenylamine reaction giving increased sensitivity and simplicity in the estimation of DNA. Analyt Biochem 57:369-376
43. Rosenberger SF, Bowden GT (1996) Okadaic acid stimulated TRE binding activity in a papilloma producing mouse keratinocyte cell line involves increased AP-1 expression. Oncogene 12:2301-2308
44. Sentman CL, Shutter JR, Hockenberry D, Kanagawa O, Korsmeyer SJ (1990) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888
45. 2+ accumulation and early DNA fragmentation with cell ceath. Tox Appl Pharm 111:242-254
46. Shupnik MA, Greenspan SL, Ridgway EC (1986) Transcriptional regulation of thyrotropin subunit genes by thyrotropin-releasing hormone and dopamine in pituitary cell culture. J Biol Chem 261:12675-12679
47. Song Q, Lavin MF (1993) Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis. Biochem Biophys Res Commun 190:47-55
48. Song Q, Baxter GD, Kovacs EM, Findik D, Lavin MF (1992) Inhibition of apoptosis in human tumour cells by okadaic acid. J Cell Physiol 153:550-556
49. Steinfelder HJ, Hauser P, Nakayama Y, Radovick S, McClaskey JH, Taylor T, Weintraub BD, Wondisford FE (1991) Thyrotropin-releasing hormone regulation of human TSHß expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element. Proc Natl Acad Sci USA 88:3130-3134
50. Steinfelder HJ, Radovick S, Mroczynski MA, Hauser P, McClaskey JH, Weintraub BD, Wondisford FE (1992a) Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-beta subunit gene expression. J Clin Invest 89:409-419
51. Steinfelder HJ, Radovick S, Wondisford FE (1992b) Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1. Proc Natl Acad Sci USA 89:5942-5945
52. Tachibana K, Scheuer PJ, Tsukitani Y, Kikuchi H, van Engen D, Clardy J, Gopichand Y, Schmitz FJ (1981) Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria. J Am Chem Soc 103:2469-2471
53. Tashjian AH (1979) Clonal strains of hormone-producing pituitary cells. Methods Enzymol 58:527-535
54. Tashjian AH, Yasamury Y, Levine L, Sato GH, Parker ML (1968) Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. Endocrinology 82:342-352
55. Tashjian AH, Lomedico ME, Maina D (1978) Role of calcium in the thyrotropin-releasing hormone-stimulated release of prolactin from pituitary cells in culture. Biochem Biophys Res Commun 81:798-806
56. Tenniswood M, Taillefer D, Lakins J, Guenette R, Mooibroek M, Daehlin L, Weish J (1994) Control of gene expression during apoptosis in hormone-dependent tissue. In: Tomei LD, Cope FO (eds) Apoptosis II - The molecular basis of apoptosis in disease. Cold Spring Harbor Laboratory Press, New York pp 283-311
57. Tounekti O, Pron G, Belehradek J, Mir LM (1993) Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized. Cancer Res 53:5462-5469
58. 4 rat pituitary cells. J Cell Physiol 152:190-198
59. Vorwerk H, v. Zezschwitz C, Steinfelder HJ (1995) Apoptotic response to okadaic acid, an inhibitor of ser/thr phosphatases. Naunyn-Schmiedeherg's Arch Pharmacol 351 [Suppl]:R61
60. Wang Q, Raghow R (1996) Okadaic acid-induced transcriptional downregulation of type I collagen gene expression is mediated by protein phosphatase 2A. Mol Cell Biochem 158:33-42
61. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556
62. Wyllie AH (1987) Apoplosis: cell death in tissue regulation. J Pathol 153:313-316