Garlic preserves patency and delays hyperthermia-induced thrombosis in pial microcirculation

International Journal of Hyperthermia

Volumn 12, Issue 4, 1996, Pages 513-525

  El Sabban, F ^a   Fahim, M A ^a   Radwan, G M H ^a   Zaghloul, S S ^a   Singh, S ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Cerebral; Embolism; Garlic; Hyperthermia; Microcirculation; Mouse; Pial; Thrombosis

Indexed keywords

ANIMAL MODEL; ARTERIOLE; ARTICLE; BRAIN CORTEX; CEREBROSPINAL FLUID; CONTROLLED STUDY; CORE TEMPERATURE; GARLIC; HYPERTHERMIC THERAPY; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; PHARMACOLOGY; POWDER; THROMBOGENESIS; THROMBOSIS; VENULE; VIDEORECORDING;

EID: 0029780783     PISSN: 02656736     EISSN: None     Source Type: Journal    
DOI: 10.3109/02656739609023528     Document Type: Article

References (27)

1. ALI, M., and MOHAMMED, S. Y., 1986, Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. Prostaglandins, Leukotrienes and Medicine, 25, 139-146.
2. APITZ-CASTRO, R., BADIMON, J. J., and BADIMON, L., 1992, Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation. Thrombosis Research, 68, 145-155.
3. APITZ-CASTRO, R., BADIMON, J. J., and BADIMON, L., 1994, A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model. Thrombosis Research, 75, 243-249.
4. ARIGA, T., OSHIBA, S., and TAMADA, T., 1981, Platelet aggregation inhibitor in garlic. Lancet, 1, (January 17), 150-151.
5. CHAO, T. C., 1987, Post-mortem findings of heat stroke. Heat Stress: Physical Exertion and Environment, edited by J. R. S. Hales and D. A. B. Richards (Amsterdam:Elsevier Science), pp. 297-302.
6. DEBOER, L. W., and FOLTS, J. D., 1989, Garlic extract prevents acute platelet thrombus formation in stenosed canine coronary arteries. American Heart Journal, 117, 973-975.
7. EL-SABBAN, F., and FAHIM, M. A., 1995, Local hyperthermia induces spontaneous thrombosis and arteriolar constriction in the pia mater of the mouse, International Journal of Biometerology, 38, 92-97.
8. EL-SABBAN, F., FAHIM, M. A., and MUSTAFA, K. Y., 1995a, Aspirin influences mouse pial microvascular responses to regional hyperthermia. Pathophysiology, 2, 217-222.
9. EL-SABBAN, F., FAHIM, M. A., AL Homsi, M. F. and SINGH, S., 1995b, Dehydration and food deprivation exacerbate mouse cerebral responses to local hyperthermia, Journal of Thermal Biology, 20, 469-476.
10. FAHIM, M. A., and EL-SABBAN, F., 1995, Hyperthermia induces ultrastructural changes in mouse pial microvessels. The Anatomical Record, 242, 77-82.
11. HARENBERG, J., GIESE, C., and ZIMMERMANN, R., 1988, Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia. Atherosclerosis, 74, 247-249.
12. JUNG, E. M., JUNG, F., MROWIETZ, C., KIESEWETTER, H., PINDUR, G., and WENZEL, E., 1991, Influence of garlic powder on cutaneous microcircuiation. A randomized placebo-controlled double-blind cross-over study in apparently healthy subjects. Arzneimittel-Forschung, 41, 626-630.
13. KAWAKISHI, S., and MORIMITSU, Y., 1988, New inhibition of platelet aggregation in onion. Lancet, 2, (August 6), 330.
14. KIESEWETTER, H., JUNG, F., PINDUR, G., JUNG, E. M., MROWIETZ, C., and WELZEL, E., 1991, Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. International Journal of Clinical Pharmacology, Therapy and Toxicology, 29, 151-155.
15. LEGNANI, C., FRASCARO, M., GUAZZALOCA, G., Lu DOVICI, S., CESARANO, G., and COCCHERI, S., 1993, Effects of dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects. Arzneimittel-Forschung, 43, 119-122.
16. MAKHEJA, A. N., VANDERHOEK, J. Y., and BAILEY, J. M., 1979, Effects of onion (Allium cepd) extract on platelet aggregation and thromboxane synthesis. Prostaglandins, Leukotrienes and Medicine, 2, 413-424.
17. MAKHEJA, A. N., VANDERHOEK, J. Y., BRYANT, R. W., and BAILY, J. M., 1980, Altered arachidonic acid metabolism in platelets inhibited by onion or garlic extracts. Advances in Prostaglandin and Thromboxane Research, 6, 309-312.
18. MAYEUX, P. R., AGARWAL, K. C., TOU, J. S., KING, B. T., LIPTON, H. L., HYMAN, A. L., KADOWITZ, P. J., and MCNAMARA, D. B., 1988, The pharmacological effects of allicin, a constituent of garlic oil. Agents and actions, 25, 182-190.
19. MCMAHON, F. G., and VARGAS, R., 1993, Can garlic lower blood pressure? A pilot study. Pharmacotherapy, 13, 406-407.
20. MOHAMMED, S. F., and WOODWARD, S. C., 1986, Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum (Garlic). Thrombosis Research, 44, 793-806.
21. MUSTAFA, K. Y., OMER, O., KHOGALI, M., JAMJOOM, A., GUMAA, K. A., ABU EL NASR, N., and GADER, M. A., 1985, Blood coagulation and fibrinolysis in heat stroke. British Journal of Haematology, 63, 517-523.
22. OKUYAMA, T., FUJITA, K., SHIBATA, S., HOSON, M., KAWADA, T., MASAKI, M., and YAMATE, N., 1989, Effects of Chinese drugs "xiebai" and "dasuan" on human platelet aggregation (Allium bakeri, A. sativum). Planta Medico, 55, 242-244.
23. ROSENBLUM, W. I., and EL-SABBAN, F., 1977, Platelet aggregation in cerebral microcirculation: effect of aspirin and other agents. Circulation Resarch, 40, 320-328.
24. SRTVASTAVA, K. C., 1984, Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism. Biomedica Biochimia Acta, 43, S335-336.
25. SRIVASTAVA, K. C., 1986a, Onion exerts anti aggregatory effects by altering arachidonic acid metabolism in platelets. Prostaglandins, Leukotrienes and Medicine, 24, 43-50.
26. SRIVASTAVA, K. C., 1986b, Evidence for the mechanism by which garlic inhibits platelet aggregation. Prostaglandins, Leukotrienes and Medicine, 22, 313-321.
27. VANDERHOEK, J. Y., MAKHEJA, A. N., and BAILEY, J. M., 1980, Inhibition of fatty acid oxygenases by onion and garlic oils. Evidence for the mechanism by which these oils inhibit platelet aggregation. Biochemical Pharmacology, 29, 3169-3173.