Serotonin alters multi-segmental convergence patterns in spinal cord deep dorsal horn and intermediate laminae neurons in an in vitro young rat preparation

Pain

Volumn 95, Issue 1-2, 2002, Pages 7-14

  Shay, Barbara L ^a   Hochman, Shawn ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 hydroxytryptamine; Neuromodulation; Nociception; Pain; Receptive field

Indexed keywords

BICUCULLINE; SEROTONIN; STRYCHNINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EVOKED SOMATOSENSORY RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITORY POSTSYNAPTIC POTENTIAL; NERVE CELL STIMULATION; NEUROMODULATION; NEWBORN; NOCICEPTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SEROTONINERGIC SYSTEM; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; THORACOLUMBAR SPINE;

ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY POSTSYNAPTIC POTENTIALS; FREE RADICAL SCAVENGERS; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SPINAL CORD; SPINAL NERVE ROOTS; SYNAPTIC TRANSMISSION;

EID: 0036149129     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00364-5     Document Type: Article

References (63)

1. 1 agonists and antagonists on nociceptive processing in the rat spinal cord: Results from behavioural and electrophysiological studies
2. The cutaneous withdrawal reflex in human neonates: Sensitization, receptive fields, and the effects of contralateral stimulation
3. Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry
4. Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation: The appearance of responding cells in a previously non-responsive region
5. Depression of activities of dorsal horn convergent neurones by propriospinal mechanisms triggered by noxious inputs; comparison with diffuse noxious inhibitory controls (DNIC)
6. Responses of rat spinal dorsal horn neurons to intracutaneous microinjection of histamine, capsaicin, and other irritants
7. Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence
8. The thermal grill illusion: Unmasking the burn of cold pain
9. Periaqueductal gray stimulation-induced inhibition of nociceptive dorsal horn neurons in rats is associated with the release of norepinephrine, serotonin, and amino acids
10. The tract of Lissauer in relation to sensory transmission in the dorsal horn of spinal cord in the macaque monkey
11. Plasticity in the spinal cord sensory map following peripheral nerve injury in rats
12. Diffuse noxious inhibitory controls (DNIC) in the rat with or without pCPA pretreatment
13. Brainstem control of spinal pain-transmission neurons
14. The post-natal development of cutaneous afferent fibre input and receptive field organization in the rat dorsal horn
15. The postnatal development of spinal sensory processing
16. Inhibitory receptive fields of primate spinothalamic tract cells
17. 1A receptor stimulation on nociceptive dorsal horn neurones in rats
18. Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells
19. Expansion of receptive fields of spinal lamina I projection neurones in rats with unilateral adjuvant-induced inflammation: The contribution of dorsal horn mechanisms
20. 5-HT and motor control: A hypothesis
21. Interneuronal relay in spinal pathways from proprioceptors
22. Effects of serotonin on dorsal horn dorsal spinocerebellar tract neurons
23. Modulation of responses of four types of feline ascending tract neurons by serotonin and noradrenaline
24. Effects of monoamines on interneurons in four spinal reflex pathways from group I and/or group II muscle afferents
25. Corelease of two fast neurotransmitters at a central synapse
26. Serotonin-induced population primary afferent depolarisation in vitro: The effects of neonatal capsaicin treatment
27. Modulation of afferent-evoked neurotransmission by 5-HT3 receptors in young rat dorsal horn neurones in vitro: A putative mechanism of 5-HT3 induced anti-nociception
28. Tonic descending influences on receptive-field properties of nociceptive dorsal horn neurons in sacral spinal cord of rat
29. Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications
30. A novel methodology for simultaneous assessment of the effects of 5-hydroxytryptamine on primary afferent polarisation and synaptic transmission in rat dorsal horn neurones in vitro
31. Pre- and post-synaptic actions of 5-hydroxytryptamine in the rat lumbar dorsal horn in vitro: Implications for somatosensory transmission
32. Multisensory control of spinal reflex pathways
33. Laminar distribution and somatotopic organization of primary afferent fibers from hindlimb nerves in the dorsal horn. A study by transganglionic transport of horseradish peroxidase in the rat
34. Topographical features of cutaneous tactile hypoesthetic and hyperesthetic abnormalities in chronic pain
35. Neural mechanisms in somesthesis
36. Properties of single central Ia afferent fibres projecting to motoneurones
37. Role of spinal serotonin 1 receptor subtypes in thermally and mechanically elicited nociceptive reflexes
38. Differential effects of substance P on serotonin-modulated spinal nociceptive reflexes
39. Selective serotonin 1A/1B agonists differentially affect spinal nociceptive reflexes
40. Descending influences on the cutaneous receptive fields of postsynaptic dorsal column neurones in the cat
41. Transmission from group II muscle afferents is depressed by stimulation of locus coeruleus/subcoeruleus. Kölliker-Fuse and raphe nuclei in the cat
42. Formalin-induced nociception activates a monoaminergic descending inhibitory system
43. Distribution of the serotonin 5-HT2 receptor family mRNAs: Comparison between 5-HT2A and 5-HT2C receptors
44. Depolarization of group II muscle afferents by stimuli applied in the locus coeruleus and raphe nuclei of the cat
45. The organization and function of endogenous antinociceptive systems
46. Characteristics of propriospinal modulation of nociceptive lumbar spinal dorsal horn neurons in the cat
47. Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat
48. Serotonin depresses multisegmental sensory convergence and receptive field size in spinal cord neurons
49. The minimal inhibitory synaptic currents evoked in neonatal rat motoneurones
50. Dermatomes in the rat limbs as determined by antidromic stimulation of sensory C-fibers in spinal nerves
51. Behavioral and electrophysiological assessment of hyperalgesia and changes in dorsal horn responses following partial sciatic nerve ligation in rats
52. Activity-dependent changes in rat ventral horn neurons in vitro; summation of prolonged afferent evoked postsynaptic depolarizations produce a D-2-amino-5-phosphonovaleric acid sensitive windup
53. The medullary subnucleus reticularis dorsalis (SRD) as a key link in both the transmission and modulation of pain signals
54. Postsynaptic effects of long-range afferents in distant segments caudal to their entry point in rat spinal cord under the influence of picrotoxin or strychnine
55. Cutaneous inhibitory receptive fields of withdrawal reflexes in the decerebrate spinal rat
56. Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord
57. Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation
58. Spinal serotonin terminal system mediates antinociception
59. A 5-HT1-type receptor mediates the antinociceptive effect of nucleus raphe magnus stimulation in the rat
60. Heterogeneous effects of serotonin in the dorsal horn of rat: The involvement of 5-HT1 receptor subtypes
61. Noradrenergic and serotonergic mediation of spinal analgesia mechanisms