The organization and function of endogenous antinociceptive systems

Progress in Neurobiology

Volumn 50, Issue 1, 1996, Pages 49-81

  Sandkuhler J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BICUCULLINE; GLUTAMIC ACID; STRYCHNINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; BRAIN; CONTROLLED STUDY; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; REVIEW; ZONA INCERTA;

ANIMALS; BRAIN; BRAIN STEM; DIENCEPHALON; EFFERENT PATHWAYS; HUMANS; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; NEUROTRANSMITTER AGENTS; PAIN; PERIAQUEDUCTAL GRAY; PROTO-ONCOGENE PROTEINS C-FOS; RATS; SPINAL CORD;

EID: 0030248857     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(96)00031-7     Document Type: Review

References (172)

1. Abercrombie, E. D. and Jacobs, B. L. (1987) Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli. J. Neurosci. 7, 2837-2843.
2. Agnati, L. F., Fuxe, K., Zoli, M., Ozini, L., Toffano, G. and Ferraguti, F. (1986) A correlation analysis of the regional distribution of central enkephalin and beta-endorphin immunoreactive terminals and of opiate receptors in adult and old male rats. Evidence for the existence of two main types of communication in the central nervous system: the volume transmission and the wiring transmission. Acta Physiol. Scand. 128, 201-207.
3. Aimone, L. D. and Gebhart, G. F. (1987) Spinal monoamine mediation of stimulation-produced antinociception from the lateral hypothalamus. Brain Res. 403, 290-300.
4. Alstermark, B., Isa, T. and Tantisira, B. (1991) Pyramidal excitation in long propriospinal neurones in the cervical segments of the cat. Expl Brain Res. 84, 569-582.
5. Aston-Jones, G., Ennis, M., Pieribone, V. A., Nickell, W. T. and Shipley, M. T. (1986) The brain nucleus locus coeruleus: restricted afferent control of a broad efferent network. Science 234, 734-737.
6. Atrens, D. M., Cobin, D. M. and Paxinos, G. (1977) Reward-aversion analysis of rat mesencephalon. Neurosci. Lett. 6, 197-201.
7. Bandler, R. and Tork, I. (1987) Midbrain periaqueductal grey region in the cat has afferent and efferent connections with solitary tract nuclei. Neurosci. Lett. 74, 1-6.
8. Basbaum, A. I., Clanton, C. H. and Fields, H. L. (1976) Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway. Proc. Natl Acad. Sci. USA 73, 4685-4688.
9. Basbaum, A. I., Clanton, C. H. and Fields, H. L. (1978) Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J. Comp. Neurol. 178, 209-224.
10. Basbaum, A. I. and Fields, H. L. (1979) The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J. Comp. Neurol. 187, 513-532.
11. Basbaum, A. I. and Fields, H. L. (1984) Endogenous pain control system: brainstem, spinal pathways and endorphin circuitry. Neuroscience 7, 309-338.
12. Beck, H., Schröck, H. and Sandkühler, J. (1995) Controlled superfusion of the rat spinal cord for studying non-synaptic transmission: an autoradiographic analysis. J Neurosci. Meth. 58, 193-202.
13. Beck, H. and Sandkühler, J. (1993) Role of volume transmission for spinal nociception: extrasynaptic mediators of immediate early gene expression. IASP Publications. Abstr. - VIIth World Congr. Pain, p. 472.
14. Beecher, H. K. (1946) Pain in men wounded in battle. Ann. Surg. 123, 96-105.
15. Behbehani, M. M. (1995) Functional characteristics of the midbrain periaqueductal gray. Prog. Neurobiol. 46, 575-605.
16. Beitz, A. J. and Buggy, J. (1981) Brain functional activity during PAG stimulation-produced analgesia: a 2-DG study. Brain Res. Bull. 6, 487-494.
17. Beitz, A. J. and Shepard, R. D. (1985) The midbrain periaqueductal gray in the rat. II. A golgi analysis. J. Comp. Neurol. 237, 460-475.
18. Berge, O.-G. (1982) Effects of 5-HT receptor agonists and antagonists on a reflex response to radiant heat in normal and spinally transected rats. Pain 13, 253-266.
19. Bernard, C. and Wheal, H. V. (1995) Expression of EPSP/spike potentiation following low frequency and tetanic stimulation in the CA1 area of the rat hippocampus. J. Neurosci. 15, 6542-6551.
20. Besson, J. M. and Chaouch, A. (1987) Peripheral and spinal mechanisms of nociception. Physiol. Rev. 67, 67-186.
21. Bett, K. and Sandkühler, J. (1995) Map of spinal neurons activated by chemical stimulation in the nucleus raphe magnus of the unanesthetized rat. Neuroscience 67, 497-504.
22. Bing, Z., Villnueva, L. and Le Bars, D. (1990) Acupuncture and diffuse noxious inhibitory controls: naloxone-reversible depression of activities of trigeminal convergent neurons. Neuroscience 37, 809-818.
23. Bonham, A. C. and Jeske, I. (1989) Cardiorespiratory effects of DL-homo cysteic acid in caudal ventrolateral medulla. Am. J. Physiol. 256, H688-H696.
24. Bouhassira, D., Gall, O., Chitour, D. and Le Bars, D. (1995) Dorsal horn convergent neurones: negative feedback triggered by spatial summation of nociceptive afferents. Pain 62, 195-200.
25. Cadden, S. W., Villanueva, L., Chitour, D. and Le Bars, D. (1983) Depression of activities of dorsal horn convergent neurones by propriospinal mechanisms triggered by noxious inputs: comparison with diffuse noxious inhibitory controls (DNIC). Brain Res. 275, 1-11.
26. Carstens, E. (1986) Hypothalamic inhibition of rat dorsal horn neuronal responses to noxious skin heating. Pain 25, 95-107.
27. Carstens, E. and Douglass, D. K. (1995) Midbrain suppression of limb withdrawal and tail flick reflexes in the rat: correlates with descending inhibition of sacral spinal neurons. J. Neurophysiol. 73, 2179-2194.
28. Chance, W. T., White, A. C., Krynock, G. M. and Rosecrans, J. A. (1977) Autoanalgesia: behaviorally activated antinociception. Eur. J. Pharmacol. 44, 283-284.
29. Chung, K. and Coggeshall, R. E. (1983) Propriospinal fibers in the rat. J. Comp. D. Neurol. 217, 47-53.
30. Cocatre-Zilgien, J. H. and Delcomyn, F. (1992) Identification of bursts in spike trains. J. Neurosci. Meth. 41, 19-30.
31. Collins, J. G., Ren, K., Saito, Y., Iwasaki, H. and Tang, J. (1990) Plasticity of some spinal dorsal horn neurons as revealed by pentobarbital-induced disinhibition. Brain Res. 525, 189-197.
32. Colquhoun, D. and Hawkes, A. G. (1981) On the stochastic properties of single ion channels. Proc. R. Soc. Lond. B 211, 205-235.
33. Coyle, J. T., Molliver, M. E. and Kuhar, M. J. (1978) In situ injection of kainic acid: a new method for selectively lesioning neuronal cell bodies while sparing axons of passage. J. Comp. Neurol. 180, 301-324.
34. Curtis, D. R. and Malik, R. (1985) A neurophysiological analysis of the effect of kainic acid on nerve fibres and terminals in the cat spinal cord. J. Physiol. Lond. 368, 99-108.
35. 3 receptor subtypes modulate responses to noxious colorectal distension in the rat. Brain Res. 538, 64-75.
36. Dean, P., Mitchell, I. and Redgrave, P. (1988) Responses resembling defensive behaviour produced by microinjection of glutamate into superior colliculus of rats. Neuroscience 24, 501-510.
37. Debus, S. and Sandkühler, J. (1996) Low dimensional attractors in discharges of sensory neurons in the rat spinal dorsal horn are maintained by supraspinal descending systems. Neuroscience 70, 191-200.
38. Depaulis, A. and Bandler, R. (1991) The Midbrain Periaqueductal Gray Matter. Plenum Press: New York.
39. Dickenson, A. H. and Le Bars, D. (1987) Supraspinal morphine and descending inhibitions acting on the dorsal horn of the rat. J. Physiol. Lond. 384, 81-107.
40. Dickhaus, H., Pauser, G. and Zimmermann, M. (1985) Tonic descending inhibition affects intensity coding of nociceptive responses of spinal dorsal horn neurones in the cat. Pain 23, 145-158.
41. Dragunow, M., Currie, R. W., Robertson, H. A. and Faull, R. L. M. (1989) Heat shock induces c-fos protein-like immunoreactivity in glial cells in adult rat brain. Expl Neurol. 106, 105-109.
42. Dragunow, M. and Faull, R. (1989) The use of c-fos as a metabolic marker in neuronal pathway tracing. J. Neurosci. Meth. 29, 261-265.
43. Dragunow, M. and Robertson, H. A. (1988) Brain injury induces c-Fos protein(s) in nerve and glial-like cells in adult mammalian brain. Brain Res. 455, 295-299.
44. Du, H.-J. and Chao, Y. F. (1976) Localization of central structures involved in descending inhibitory effect of acupuncture on viscero-somatic discharges. Sci. Sin. Ser. B 19, 137-148.
45. Du, H.-J. and Zhou, S.-Y. (1990) Involvement of solitary tract nucleus in control of nociceptive transmission in cat spinal cord neurons. Pain 40, 323-331.
46. Dubuisson, D. and Wall, P. D. (1980) Descending influences on receptive fields and activity of single units recorded in laminae 1, 2 and 3 of cat spinal cord. Brain Res. 199, 283-298.
47. Duggan, A. W., Griersmith, B. T. and North, R. A. (1980) Morphine and supraspinal inhibition of spinal neurones: evidence that morphine decreases tonic descending inhibition in the anesthetized cat. Br. J. Pharmacol. 69, 461-466.
48. Duggan, A. W., Morton, C. R., Hutchison, W. D. and Hendry, I. A. (1988) Absence of tonic supraspinal control of substance P release in the substantia gelatinosa of the anesthetized cat. Expl Brain Res. 71, 597-602.
49. Duggan, A. W., Hope, P. J., Jarrott, B., Schaible, H.-G. and Fleetwood-Walker, S. M. (1990) Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes. Neuroscience 35, 195-202.
50. 3H] 2-deoxyglucose. J. Neurosci. Meth. 20, 105-113.
51. Duncan, G. E., Johnson, K. B. and Breese, G. R. (1993) Topographic patterns of brain activity in response to swim stress: assessment by 2-deoxyglucose uptake and expression of Fos-like immunoreactivity. J. Neurosci. 13, 3932-3943.
52. Dunwiddie, T. and Lynch, G. (1978) Long-term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency. J. Physiol. Lond. 276, 353-367.
53. Dupont, E., Christensen, S. E., Hansen. A. P., De Fine Olivarius, B. and Orskov, H. (1982) Low cerebrospinal fluid somatostatin in Parkinson's disease: an irreversible abnormality. J. Neurol. 32, 312-314.
54. Eckman, J. P. and Ruelle, D. (1985) Ergodic theory of chaos and strange attractors. Rev. Mod. Phys. 57, 617-656.
55. Fardin, V., Oliveras, J.-L. and Besson, J. M. (1984) A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat. I. The production of behavioral side effects together with analgesia. Brain Res. 306, 105-123.
56. Fields, H. L., Heinricher, M. M. and Mason, P. (1991) Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14, 219-245.
57. Fields, H. L., Malick, A. and Burstein, R. (1995) Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J. Neurophysiol. 74, 1742-1759.
58. Fields. H. L. and Basbaum, A. I. (1978) Brainstem control of spinal pain-transmission neurons. Annu. Rev. Physiol. 40, 217-248.
59. Gebber, G. L., Barman, S. M. and Kosics, B. (1990) Coherence of medullary unit activity and sympathetic nerve discharge. Am. J. Physiol. 259, R561-R571.
60. Gebhart, G. F. (1982) Opiate and opioid peptide effects on brain stem neurons: relevance to nociception and antinociceptive mechanisms. Pain 12, 93-140.
61. Gebhart, G. F., Sandkühler, J., Thalhammer J. G. and Zimmermann, M. (1983) Inhibition of spinal nociceptive information by stimulation in midbrain of the cat is blocked by lidocaine microinjected in nucleus raphe magnus and medullary reticular formation. J. Neurophysiol. 50, 1446-1459.
62. Gebhart, G. F., Sandkühler, J., Thalhammer, J. G. and Zimmermann, M. (1984) Inhibition in spinal cord of nociceptive information by electrical stimulation and morphine microinjection at identical sites in midbrain of the cat. J. Neurophysiol. 51, 75-89.
63. Gebhart, G. F. and Ossipov, M. H. (1986) Characterization of inhibition of the spinal nociceptive tall-flick reflex in the rat from the medullary lateral reticular nucleus. J. Neurosci. 6, 701-713.
64. Gerhart, K. D., Yezierski, R. P., Giesler, G. J. and Willis, W. D. (1981) Inhibitory receptive fields of primate spinothalamic tract cells. J. Neurophysiol. 46, 1309-1325.
65. Gioia, M., Tredici, G. and Bianchi, R. (1985) A golgi study of the peri-aqueductal gray matter in the cat. Neuronal types and their distribution. Expl Brain Res. 58, 318-332.
66. Gogas, K. R., Presley, R. W., Levine, J. D. and Basbaum, A. I. (1991) The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behavior and c-fos expression. Neuroscience 42, 617-628.
67. Gonzalez-Lima, F. (1986) Activation of substantia gelatinosa by midbrain reticular stimulation demonstrated with 2-deoxyglucose in the rat spinal cord. Neurosci. Lett. 65, 326-330.
68. Grabfield, G. P. and Martin, E. G. (1913) Variations in the sensory threshold for faradic stimulation in normal human subjects. I. The diurnal rhythm. Am. J. Physiol. 31, 300-308.
69. Grassberger, P. and Procaccia, I. (1983) Measuring the strangeness of strange attractors. Physica D 9, 189.
70. 2-adrenoceptor agonist in the spinal dorsal horn is due to a direct spinal action and not to activation of descending inhibition. Brain Res. Bull. 37, 581-587.
71. Handwerker, H. O., Iggo, A. and Zimmermann, M. (1975) Segmental and supraspinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuli. Pain 1, 147-165.
72. Helmchen, C., Fu, Q.-G. and Sandkühler, J. (1995) Inhibition of spinal nociceptive neurons by microinjection of somatostatin into the nucleus raphe magnus and the midbrain periaqueductal gray of the anesthetized cat. Neurosci. Lett. 187, 137-141.
73. Henry, J. L. (1982) Circulating opioids: possible physiological roles in central nervous function. Neurosci. Behav. Rev. 6, 229-245.
74. Hentall, I. D., Zorman, G., Kansky, S. and Fields, H. L. (1984) An estimate of minimum number of brain stem neurons required for inhibition of a flexion reflex. J. Neurophysiol. 51, 978-985.
75. Hentall, I. D., Barbaro, N. M. and Fields, H. L. (1991) Spatial and temporal variation of microstimulation thresholds for inhibiting the tail-flick reflex from the rat's rostral medial medulla. Brain Res. 548, 156-162.
76. Herdegen, T., Sandkühler, J., Gass, P., Kiessling, M., Bravo, R. and Zimmermann, M. (1993) JUN, FOS, KROX and CREB transcription factor proteins in the rat cortex: basal expression and induction by spreading depression and epileptic seizures. J. Comp. Neurol. 333, 271-288.
77. Herrero, J. F. and Headley, P. M. (1995) Cutaneous responsiveness of lumbar spinal neurons in awake and halothane-anesthetized sheep. J. Neurophysiol. 74, 1549-1562.
78. Hisanaga, K., Sagar, S. M., Hicks, K. J., Swanson, R. A. and Sharp, F. R. (1990) c-fos Proto-oncogene expression in astrocytes associated with differentiation or proliferation but not depolarization. Mol. Brain Res. 8, 69-75.
79. Hosobuchi, Y., Adams, J. E. and Linchitz, R. (1977) Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science 197, 183-186.
80. Inui, K., Murase, S. and Nosaka, S. (1994) Facilitation of the arterial baroreflex by the ventrolateral part of the midbrain periaqueductal grey matter in rats. J. Physiol. Lond. 477, 89-101.
81. Ishida, M. and Shinozaki, H. (1988) Acromelic acid is a much more potent excitant than kainic acid or domoic acid in the isolated rat spinal cord. Brain Res. 474, 386-389.
82. Ishimaru, K., Kawakita, K. and Sakita, M. (1995) Analgesic effects induced by TENS and electroacupuncture with different types of stimulating electrodes on deep tissues in human subjects. Pain 63, 181-187.
83. 3H]serotonin from tissue slices of rat ventral spinal cord. Acta Physiol. Scand. 137, 63-71.
84. Janss, A. J., Jones, S. L. and Gebhart, G. F. (1987) Effect of spinal norepinephrine depletion on descending inhibition of the tail flick reflex from the locus coeruleus and lateral reticular nucleus in the rat. Brain Res. 400, 40-52.
85. Jayaram, A., Singh, P. and Carp, H. M. (1995) An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology 82, 1283-1287.
86. Jensen, T. S. and Yaksh, T. L. (1984) Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brain stem sites. Brain Res. 321, 287-297.
87. 1 spinal cord of the intact rat. J. Neurophysiol. 74, 1814-1827.
88. Jones, S. L. and Gebhart, G. F. (1987) Spinal pathways mediating tonic, coerulcospinal, and raphe-spinal descending inhibition in the rat. J. Neurophysiol. 58, 138-159.
89. Jones, S. L. and Light, A. R. (1990) Electrical stimulation in the medullary nucleus raphe magnus inhibits noxious heat-evoked fos protein-like immunoreactivity in the rat lumbar spinal cord. Brain Res. 530, 335-338.
90. Keay, K., Redgrave, P. and Dean, P. (1988) Cardiovascular and respiratory changes elicited by stimulation of rat superior colliculus. Brain Res. Bull. 20, 13-26.
91. Keay, K. A. and Bandler, R. (1993) Deep and superficial noxious stimulation increases Fos-like immunoreactivity in different regions of the midbrain periaqueductal grey of the rat. Neurosci. Lett. 154, 23-26.
92. Kelly, S. J. and Franklin, K. B. J. (1984) Electrolytic raphe magnus lesions block analgesia induced by a stress-morphine interaction but not analgesia induced by morphine alone. Neurosci. Lett. 52, 147-152.
93. Laird, J. M. A. and Cervero, F. (1990) Tonic descending influences on receptive-field properties of nociceptive dorsal horn neurons in sacral spinal cord of rat. J. Neurophysiol. 63, 1022.
94. Le Bars, D., Dickenson, A. H. and Besson, J. M. (1979a) Diffuse noxious inhibitory controls (DNIC). I. effects on dorsal horn convergent neurones in the rat. Pain 6, 283-304.
95. Le Bars, D., Dickenson, A. H. and Besson, J. M. (1979b) Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications. Pain 6, 305-327.
96. Levine, J. D., Fields, H. L. and Basbaum, A. I. (1993) Peptides and the primary afferent nociceptor. J. Neurosci. 13, 2273-2286.
97. Li. Y.-X. and Goldbeter, A. (1992) Pulsatile signaling in intracellular communication. Periodic stimuli are more efficient than random or chaotic signals in a model based on receptor desensitization. Biophys. J. 61, 161-171.
98. Light, A., Casale, E. and Mentrey, D. (1986) The effects of focal stimulation in nucleus raphe magnus and periaqueductal gray on intracellularly recorded neurons in spinal laminae I and II. J. Neurophysiol. 56, 555-571.
99. Lima, D., Montes Ribeiro, J. A. and Coimbra, A. (1991) The spino-latero-reticular system of the rat: projections from the superficial dorsal horn and structural characterization of marginal neurons involved. Neuroscience 45, 137-152.
100. Lindblom, U. and Meyerson, B. A. (1976) On the effect of electrical stimulation of the dorsal column system on sensory thresholds in patients with chronic pain. Progress in Brain Research, Vol. 43: Somatosensory and Visceral Receptor Mechanisms, pp. 237-241. Eds A. Iggo and O. B. Ilyinsky. Elsevier: Amsterdam
101. Liu, X.-G. and Sandkühler, J. (1995a) The effects of extrasynaptic substance P on nociceptive neurons in laminae I and II in rat lumbar spinal dorsal horn. Neuroscience 68, 1207-1218.
102. Liu, X.-G. and Sandkühler, J. (1995b) Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-D-aspartic acid receptor blockage. Neurosci. Lett. 191, 43-46.
103. Liu, X.-G. and Sandkühler, J. (1996) Long-term potentiation of spinal C-fiber-evoked potentials induced by skin inflammation or nerve injury. IASP press. Abstr. 8th World Congress on Pain, p. 40.
104. Long, D. M. and Hagfors, N. (1975) Electrical stimulation in the nervous system: the current status of electrical stimulation of the nervous system for relief of pain. Pain 1, 109-123.
105. Mantyh, P. W. (1983a) Connections of midbrain periaqueductal gray in the monkey. I. Ascending efferent projections. J. Neurophysiol. 49, 567-581.
106. Mantyh, P. W. (1983b) Connections of midbrain periaqueductal gray in the monkey. II. Descending efferent projections. J. Neurophysiol. 49, 582-594.
107. McMahon, S. B. and Wall, P. D. (1988) Descending excitation and inhibition of spinal cord lamina I projection neurons. J. Neurophysiol. 59, 1204-1219.
108. Melzack, R. and Wall, P. D. (1965) Pain mechanisms: a new theory. Science 150, 971-979.
109. Menétrey, D., De Pommery, J. and Roudier, J. (1985) Propriospinal fibers reaching lumbar enlargement in the rat. Neurosci. Lett. 58, 257-261.
110. Menétrey, D., Gannon, A., Levine, J. D. and Basbaum, A. I. (1989) Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J. Comp. Neurol. 285, 177-195.
111. Millan, M. J., Przewlocki, R. and Herz, A. (1980) A non-beta-endorphinergic adenohypophyseal mechanism is essential for an analgetic response to stress. Pain 8, 343-353.
112. Moreau, J.-L. and Fields, H. L. (1986) Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission. Brain Res. 397, 37-46.
113. Morgan, J. I., Cohen, D. R., Hempstead, J. L. and Curran, T. (1987) Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237, 192-197.
114. Morgan, J. I. and Curran, T. (1986) Role of ion flux in the control of c-fos expression. Nature 322, 552-555.
115. Morgan, M. M., Heinricher, M. M. and Fields, H. L. (1992) Circuitry linking opioid-sensitive nociceptive modulatory systems in periaqueductal gray and spinal cord with rostral ventromedial medulla. Neuroscience 47, 863-871.
116. Morton, C. R., Duggan, A. W. and Zhao, Z. Q. (1983) Inhibition in the dorsal horn from periaqueductal grey stimulation: the relative contributions of the medullary raphe and lateral reticular areas. Neurosci. Lett. Suppl. 11, S64.
117. Oliveras, J.-L., Martin, G., Montagne, J. and Vos, B. (1990) Single unit activity at ventromedial medulla level in the awake freely moving rat: effects of noxious heat and light tactile stimuli onto convergent neurons. Brain Res. 506, 19-30.
118. Oliverio, A., Castellano, C. and Puglisi-Allegra, S. (1982) Opiate analgesia: evidence for circadian rhythms in mice. Brain Res. 249, 265-270.
119. Ossipov, M. H. and Gebhart, G. F. (1984) Light pentobarbital anesthesia diminishes the antinociceptive potency of morphine administered intracranially but not intrathecally in the rat. Eur. J. Pharmacol. 97, 137-140.
120. Peyron, R., Garcia-Larrea, L., Deiber, M. P., Cinotti, L., Convers, P., Sindou, M., Mauguière, F. and Laurent, B. (1995) Electrical stimulation of precentral cortical area in the treatment of central pain: Electrophysiological and PET study. Pain 62, 275-286.
121. Pitcher, G. M., Yashpal, K., Coderre, T. J. and Henry, J. L. (1995) Mechanisms underlying antinociception provoked by heterosegmental noxious stimulation in the rat tail-flick test. Neuroscience 65, 273-281.
122. Prieto, G. J., Cannon, J. T. and Liebeskind, J. C. (1983) N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat. Brain Res. 261, 53-57.
123. Raby, W. N. and Renaud, L. P. (1989) Dorsomedial medulla stimulation activates rat supraoptic oxytocin and vasopressin neurones through different pathways. J. Physiol. Lond. 417, 279-294.
124. Randić, M., Jiang, M. C. and Cerne, R. (1993) Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord. J. Neurosci. 13, 5228-5241.
125. Reynolds, D. V. (1969) Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science 164, 444-445.
126. Rogers, E. J. and Vilkin, B. (1978) Diurnal variation in sensory and pain thresholds correlated with mood states. J. Clin. Psychiat. 39, 431-438.
127. Sagar, S. M., Sharp, F. R. and Curran, T. (1988) Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 240, 1328-1331.
128. Sakuma, Y. and Pfaff, D. W. (1980) Convergent effects of lordosis - relevant somatosensory and hypothalamic influences on central gray cells in the rat mesencephalon. Expl Neurol. 70, 269-281.
129. Sandkühler, J. (1991) Induction of the proto-oncogene c-fos as a cellular marker of brainstern neurons activated from the PAG. In: The Midbrain Periaqueductal Gray Matter, pp. 267-286. Eds A. Depaulis and R. Bandler. Plenum Press: New York.
130. Sandkühler, J., Fu, Q.-G and Zimmermann, M. (1987a) Spinal pathways mediating tonic or stimulation-produced descending inhibition from the periaqueductal gray or nucleus raphe magnus are separate in the cat. J. Neurophysiol. 58, 327-341.
131. Sandkühler, J., Maisch, B. and Zimmemann, M. (1987b) Raphe magnus-induced descending inhibition of spinal nociceptive neurons is mediated through contralateral spinal pathways in the cat. Neurosci. Lett. 76, 168-172.
132. Sandkühler, J., Helmchen, C., Fu, Q.-G. and Zimmermann, M. (1988) Inhibition of spinal nociceptive neurons by excitation of cell bodies or fibers of passage at various brainstern sites in the cat. Neurosci. Lett. 93, 67-72.
133. A receptors in the midbrain periaqueductal gray abolishes nociceptive spinal dorsal horn neuronal activity. Eur. J. Pharmacol. 160, 163-166.
134. Sandkühler, J., Fu, Q.-G. and Stelzer, B. (1991a) Propriospinal neurones are involved in the descending inhibition of lumbar spinal dorsal horn neurones from the mid-brain. In: Proceedings of the VIth World Congress on Pain, pp. 313-318. Eds M. R. Bond, J. E. Charlton and C. J. Woolf. Elsevier: Amsterdam.
135. Sandkühler, J., Willmann, E. and Fu, Q.-G. (1991b) Characteristics of midbrain control of spinal nociceptive neurons and nonsomatosensory parameters in the pentobarbital-anesthetized rat. J. Neurophysiol. 65, 33-48.
136. Sandkühler, J., Stelzer, B. and Fu, Q.-G. (1993) Characteristics of propriospinal modulation of nociceptive lumbar spinal dorsal horn neurons in the cat. Neuroscience 54, 957-967.
137. Sandkühler, J., Eblen-Zajjur, A. A. and Liu. X.-G. (1994) Differential effects of skin inflammation, extrasynaptic substance P and noxious skin heating on rhythmicity, synchrony and nonlinear dynamics in rat spinal dorsal horn. In: Proceedings of the VIIth World Congress on Pain. Progress in Pain Research and Management Vol.2, pp. 347-358. Eds G. F. Gebhart, D. L. Hammond and T. S. Jensen. IASP Press: Seattle, WA.
138. Sandkühler, J., Eblen-Zajjur, A., Fu, Q.-G. and Forster, C. (1995) Differential effects of spinalization on discharge patterns and discharge rates of simultaneously recorded nociceptive and non-nociceptive spinal dorsal horn neurons. Pain 60, 55-65.
139. Sandkühler, J., Treier, A.-C. Liu, X.-G. and Ohnimus, M. (1996) The massive expression of c-Fos protein in spinal dorsal horn neurons is not followed by long-term changes in spinal nociception. Neuroscience 73, 657-666.
140. Sandkühler, J. and Eblen-Zajjur, A. (1994) Identification and characterization of rhythmic nociceptive and non-nociceptive spinal dorsal horn neurons in the rat. Neuroscience 61, 991-1006.
141. Sandkühier, J. and Gebhart, G. F. (1984a) Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat. Brain Res. 305, 77-87.
142. Sandkühler, J. and Gebhart, G. F. (1984b) Characterization of inhibition of a spinal nociceptive reflex by stimulation medially and laterally in the midbram and medulla in the pentobarbital-anesthetized rat. Brain Res. 305, 67-76.
143. Sandkühler, J. and Gebhart, G. F. (1991) Production of reversible local blockage of neuronal function. In: Methods in Neurosciences, Vol. 7, Lesions and Transplantation, pp. 122-138. Ed. P. M. Conn. Academic Press: Orlando, FL.
144. Sandkühler, J. and Herdegen, T. (1995) Distinct patterns of activated neurons throughout the rat midbrain periaqueductal gray induced by chemical stimulation at its subdivisions. J. Comp. Neurol. 357, 546-553.
145. Sandkühler, J. and Randić, M. (1996) Low frequency stimulation of afferent A-fibers induces robust long-term depression of primary afferent neurotransmission in spinal cord substantia gelatinosa in vitro. IASP Press. Abstr. 8th World Congress on Pain, p. 237.
146. Sandkühler, J. and Zimmermann, M. (1988) Neuronal effects of controlled superfusion of the spinal cord with monoaminergic receptor antagonists in the cat. Progress in Brain Research, Vol. 77: Pain Modulation, pp. 321 -327. Eds H. L. Fields and J.-M. Besson. Elsevier: Amsterdam.
147. Sarna, M. F., Cochin, R., Kaltenbach, J., Salganicoff, M. and Gerstein, G. L. (1988) Unsupervised waveform classification for multi-neuron recordings: a real-time, software-based system. II. Performance comparison to other sorters. J. Neurosci. Meth. 25, 189-196.
148. Schaible, H.-G., Neugebauer, V., Cervero, F. and Schmidt, R. F. (1991) Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat. J. Neurophysiol. 66, 1021.
149. Schomburg, E. D., Steffens, H. and Warneke, G. (1986) Functional organization of the spinal reflex pathways from forelimb afferents to hindlimb motoneurones in the cat. II. Conditions of the interneuronal connections. Brain Res. 375, 280-290.
150. Shaikh, M. B. and Siegel, A. (1990) GABA-mediated regulation of feline aggression elicited from midbrain periaqueductal gray. Brain Res. 507, 51-56.
151. Shibuki, K. and Yagi, K. (1986) Synergistic activation of rat supraoptic neurosecretory neurons by noxious and hypovolemic stimuli. Expl Brain Res. 62, 572-578.
152. Siegel, A. and Pott, C. B. (1988) Neural substrates of aggression and flight in the cat. Progr. Neurobiol. 31, 261-283.
153. Singer, W. (1993) Synchronization of cortical activity and its putative role in information processing and learning. Annu. Rev. Physiol. 55, 349-374.
154. Skinner, R. D., Adams, R. J. and Remmel, R. S. (1980) Responses of long descending propriospinal neurons to natural and electrical types of stimuli in cat. Brain Res. 196, 387-403.
155. Stanfa, L. C. and Dickenson, A. H. (1994) Enhanced alpha-2 adrenergic controls and spinal morphine potency in inflammation. Neuroreport 5, 469-472.
156. Steedman, W. M. and Zachary, S. (1990) Characteristics of background and evoked discharges of multireceptive neurons in lumbar spinal cord of cat. J. Neurophysiol. 63, 1-15.
157. Stern, P., Edwards, F. A. and Sakman, B. (1992) Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex. J. Physiol. Lond, 449, 247-278.
158. Surmeier, D. J. and Towe, A. L. (1987) Properties of proprioceptive neurons in the cuneate nucleus of the cat. J. Neurophysiol. 57, 938-961.
159. Szentagothai, J. and Schadi, J. P. (1964) Propriospinal pathways and their synapses. In: Progress in Brain Research. Vol. II: Organization of the spinal cord, pp. 155-177. Eds J. C. Eccles and J. P. Schadé. Elsevier: Amsterdam.
160. Takens, F., Braaksma, B. L. J. and Broer, H. W. (1985) On the numerical determination of the dimension of an attractor. In: Lecture Notes in Mathematics, p. 99. Ed. B. L. J. Braaksma. Springer: Berlin.
161. Tattersall, J. E. H., Cervero, F. and Lumb, B. M. (1986) Effects of reversible spinalization on the visceral input to viscerosomatic neurons in the lower thoracic cord of the cat. J. Neurophysiol. 56, 785-796.
162. Urban, B. J. and Nashold, B. S. (1978) Percutaneous epidural stimulation of the spinal cord for relief of pain. J. Neurosurg. 48, 323-328.
163. Varner, K. J., Barman, S. M. and Gebber, G. L. (1988) Cat diencephalic neurons with sympathetic nerve-related activity. Am. J. Physiol. 254, R257-R267.
164. Wall, P. D. (1967) The laminar organization of dorsal horn and effects of descending impulses. J. Physiol. Lond. 188, 403-423.
165. Watkins, L. R., Cobelli, D. A. and Mayer, D. J. (1982) Classical conditioning of front paw and hind paw footshock induced analgesia (FSIA): naloxone reversibility and descending pathways. Brain Res. 243, 119-132.
166. Watkins, L. R., Faris, P. L., Komisaruk, B. R. and Mayer, D. J. (1984) Dorsolateral funiculus and intraspinal pathways mediate vaginal stimulation-induced suppression of nociceptive responding in rats. Brain Res. 294, 59-65.
167. Willis, W. D. (1988) Anatomy and physiology of descending control of nociceptive responses of dorsal horn neurons: comprehensive review. In: Progress in Brain Research, Vol. 77: Pain Modulation, pp. 1-29. Eds H. L. Fields and J.-M. Besson. Elsevier: Amsterdam.
168. Wright, D. M. (1981) Diurnal rhythm in sensitivity of a nociceptive spinal reflex. Eur. J. Pharmacol. 69, 385-388.
169. Zhang, R. X., Mi, Z. P., Xie, Y. F. and Qiao, J. T. (1993) Morphological evidence for the activation of descending modulatory control by nociceptive afferent pathways: an immunocytochemical study. Brain Res. 603, 162-165.
170. Zhuo, M. and Gebhart, G. F. (1992) Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigatocellularis pars alpha in the rat. J. Neurophysiol. 67, 1599-1614.
171. Zieglgänsberger, W., French, E. D., Siggins, G. R. and Bloom, F. E. (1979) Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. Science 205, 415-417.
172. Zieglgänsberger, W., Bloom, F. E. and Geiger, S. R. (1986) Central control of nociception. In: Handbook of Physiology - the Nervous System IV, pp. 581-645. Ed. V. B. Mountcastle. Williams and Wilkins: Baltimore.