Influence of formulation technique for hydroxypropyl-β-cyclodextrin on the stability of aspirin in HFA 134a

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 47, Issue 2, 1999, Pages 145-152

  Williams III, Robert O ^a   Liu, Jie ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b NONE

Author keywords

2 Hydroxypropyl cyclodextrin; Aspirin; Formulation technique; Hydrofluoroalkane; pMDI; Stability

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ACETYLSALICYLIC ACID; NORFLURANE;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; METERED DOSE INHALER;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLODEXTRINS; DRUG STABILITY; FREEZE DRYING; NEBULIZERS AND VAPORIZERS; WATER;

EID: 0033007855     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(98)00072-1     Document Type: Article

References (15)

1. V.J. Stella, R.A. Rajewski, Cyclodextrins: their future in drug formulation and delivery, Pharm. Res. 14 (1997) 556-567.
2. K. Uekama, H. Arima, T. Irie, K. Matsubara, T. Kuriki, Sustained release of buserelin acetate, a luteinizing hormone-releasing hormone agonist, from an injectable oily preparation utilizing ethylated β-cyclodextrin, J. Pharm. Pharmacol. 41 (1989) 874-876.
3. Y. Horiuchi, F. Hirayama, K. Uekama, Slow release characteristics of diltiazem from ethylated β-CYD complexes, J. Pharm. Sci. 79 (1990) 128-132.
4. K.A. Connors, G.L. Amidon, V.J. Stella, Chemical stability of pharmaceuticals: a handbook for pharmacists, Wiley, New York, 1986.
5. F.E. Blondino, P.R. Byron, Drug stability in non-aqueous solutions-influence of surfactant concentration, in: P.R. Byron, R.N. Dalby, S.J. Farr (Eds.), Respiratory Drug Delivery V. Interpharm Press, Buffalo Grove, IL, 1996, pp. 125-131.
6. S. Choudhury, A.K. Mitra, Kinetics of aspirin hydrolysis and stabilization in the presence of 2-hydroxylpropyl-β-cyclodextrin, Pharm. Res. 10 (1993) 156-159.
7. R.O. Williams III, J. Liu, J.J. Koleng, Influence of metering chamber volume and water level on the emitted dose of a suspension-based pMDI containing propellant 134a, Pharm. Res. 14 (1997) 438-443.
8. P.V. Mroso, A.L.W. Po, W.J. Irwin, Solid-state stability of aspirin in the presence of excipients: kinetics interpretation, modeling, and prediction, J. Pharm. Sci. 71 (1982) 1096-1101.
9. J.C. Preepmeyer, R.D. Kirchhoefer, Isolation of salicylsalicylic acid, acetylsalicylsalicylic acid and acetylsalicylic anhydride from aspirin tablets by extraction and high-pressure liquid chromatography, J. Pharm. Sci. 68 (1979) 1167-1169.
10. V.Y. Taguchi, M.L. Cotton, C.H. Yates, J.F. Millar, Determination of drug stability in aspirin tablet formulations by high-pressure liquid chromatography, J. Pharm. Sci. 70 (1981) 64-67.
11. R.N. Galante, A.J. Visalli, W.M. Grim, Stabilized normal-phase high-performance liquid chromatographic analysis of aspirin and salicylic acid in solid pharmaceutical dosage forms, J. Pharm. Sci. 73 (1984) 195-197.
12. T. Loftsson, M.E. Brewster, Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization, J. Pharm. Sci. 85 (1996) 1017-1025.
13. G. Bettinetti, F. Melani, P. Mura, R. Monnanni, F. Giordano, Carbon-13 nuclear magnetic resonance study of naproxen interaction with cyclodextrins in solution, J. Pharm. Sci. 80 (1991) 1162-1170.
14. T.F. Chin, P.H. Chung, J.L. Lach, Influence of cyclodextrins on ester hydrolysis, J. Pharm. Sci. 57 (1968) 44-48.
15. P. Jarho, A. Urtti, T. Järvinen, Hydroxypropyl-β-cyclodextrin increases the aqueous solubility and stability of pilocarpine prodrugs, Pharm. Res. 12 (1995) 1371-1375.