New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis

Current Opinion in Rheumatology

Volumn 14, Issue 1, 2002, Pages 15-22

  Savage, Caroline O S ^a   Harper, Lorraine ^a   Holland, Mark ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; MYELOBLASTIN; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROPYLTHIOURACIL;

DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; GENETIC SUSCEPTIBILITY; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VASCULITIS;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ENDOTHELIUM, VASCULAR; HUMANS; INTEGRINS; NEUTROPHILS; VASCULITIS;

EID: 0036142222     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200201000-00004     Document Type: Review

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3. Activated neutrophils express Pr3 on their plasma membrane in vitro and in vivo
4. Leukocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis
5. Are circulating neutrophils intravascularly activated in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides?
6. Antigens for anti-neutrophil cytoplasm autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils
7. Neutrophil priming and apoptosis in ANCA-associated vasculitis
8. Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis
9. Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils
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11. Epitope mapping of anti-proteinase 3 and anti-myeloperoxidase antibodies
12. ANCA in WG recognize conformational epitope(s) on Pr3
13. Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site
14. Cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: Epitope analysis using synthetic peptides
15. Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis
16. 1-antitrypsin complexation to disease activity in Wegener's granulomatosis
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18. Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis
19. IgG from MPO-ANCA positive patients stimulates greater activation of primed neutrophils than IgG from PR3-ANCA positive patients
20. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): A FcγRII-dependent process
21. Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via FcγRIIa
22. The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasm antibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation
23. The effect of anti-neutrophil cytoplasm autoantibodies on the signal transduction in human neutrophils
24. Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies
25. Autoantibodies from patients with systemic vasculitis activate primed neutrophils via Fcγ receptor dependent pathways
26. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release
27. Upregulation of CD14 and CD18 on monocytes in vitro by antineutrophil cytoplasmic autoantibodies
28. Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis
29. Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent
30. Renal expression of endothelial and inducible nitric oxide, and formation of peroxynitrite-modified proteins and reactive oxygen species in Wegener's granulomatosis
31. Proteinase 3 interacts with a 111-kD membrane molecule of human umbilical endothelial cells
32. Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro
33. Proteinase 3 enhances endothelial monocyte chemoattractant protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1
34. Apoptosis of endothelial cells induced by neutrophil serine proteases proteinase 3 and elastase
35. Internalisation of proteinase 3 is concomitant with endothelial cell apoptosis and internalisation of myeloperoxidase with generation of intracellular oxidants
36. Effect of antineutrophil cytoplasmic antibodies on proteinase 3-induced apoptosis of human endothelial cells
37. Antineutrophil cytoplasmic antibodies induce reactive oxygen-dependent dysregulation of primed neutrophil apoptosis and clearance by macrophages
38. Opsonization of apoptotic neutrophils by anti-neutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumor necrosis factor-alpha (TNF-alpha)
39. Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function: Lessons for atherosclerotic disease?
40. Prominence of cell-mediated immunity effectors in "pauci-immune" glomerulonephritis
41. T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis
42. T cell responses to myeloperoxidase (MPO) and proteinase 3 (PR3) in patients with systemic vasculitis
43. T lymphocyte responses to ANCA antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission
44. In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG)
45. T cell activation in patients with ANCA-associated vasculitis: Inefficient immune suppression by therapy
46. In situ analysis of CC chemokine mRNA in human glomerulonephritis
47. Glomerular vascular cell adhesion molecule-1 expression in renal vasculitis
48. Intraglomerular and interstitial leukocyte infiltration, adhesion molecules, and interleukin-1 α expression in 15 cases of antineutrophil cytoplasmic autoantibody-associated renal vasculitis
49. Participation of cell-mediated immunity in deposition of fibrin in glomerulonephritis
50. Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis
51. Cytokine profiles in Wegener's granulomatosis: Predominance of type 1 (Th1) in the granulomatous inflammation
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53. Active Wegener's granulomatosis is associated with HLA-DR+ CD4+ T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: Reversal with IL-10
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55. Localised Wegener's granulomatosis: Predominance of CD26 and IFNγ expression
56. Case of propylthiouracil-induced ANCA associated small vessel vasculitis
57. High prevalence of antineutrophil cytoplasmic antibody positivity in childhood onset Graves' disease treated with propylthiouracil
58. Absence of cross-reactivity to myeloperoxidase of anti-thyroid microsomal antibodies in patients with autoimmune thyroid disease
59. Perinuclear antineutrophil cytoplasmic antibody-positive cutaneous polyarteritis nodosa associated with minocycline therapy for acne vulgaris
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65. Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): Frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects
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67. A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14g32.1 is associated with Wegener's granulomatosis
68. A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis
69. Proteinase 3 gene polymorphisms and Wegener's granulomatosis
70. Effect of tumor necrosis factor-induced integrin activation on Fcγ receptor II-mediated signal transduction: Relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies
71. Activation of neutrophil β2-integrin and induction of firm adhesion by anti-neutrophil cytoplasm autoantibodies (ANCA)
72. The ANCA-associated of CD18 alleles with anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides
73. Neutrophil FcγRila allelic polymorphism in ANCA-positive vasculitis
74. Analysis of Fc gamma RII gene polymorphisms in Wegener's granulomatosis
75. Association of the FcγRIIIb-NA1 allele with renal disease in Wegener's granulomatosis
76. Neutrophil FcγRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis
77. Fcγ receptor polymorphisms in Wegener's granulomatosis: Risk factors for disease relapse
78. Polymorphisms in CTLA-4 but not tumor necrosis factor-alpha or interleukin 1beta genes are associated with Wegener's granulomatosis