Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: Epitope analysis using synthetic peptides

Kidney International

Volumn 59, Issue 1, 2001, Pages 147-159

  Van der Geld, Y M ^a   Simpelaar, A ^a   Van der Zee, R ^a   Tervaert, J W C ^a   Stegeman, C A ^a   Limburg, P C ^a   Kallenberg, C G M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

ANCA; Inflammation; Linear epitopes on PR3; Necrotizing crescentic glomerulonephritis; Serine proteinase

Indexed keywords

MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ANTIBODY SPECIFICITY; ARTICLE; DISEASE ACTIVITY; ENZYME ACTIVE SITE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; GRANULOMATOUS INFLAMMATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; WEGENER GRANULOMATOSIS;

EID: 0035167581     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.00475.x     Document Type: Article

References (52)

1. Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years
2. Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener's granulomatosis
3. Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils
4. Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase
5. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme
6. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase: Structural and functional properties
7. Association between active Wegener's granulomatosis and anticytoplasmic antibodies
8. Anti-neutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential
9. Pathophysiology of ANCA-associated glomerulonephritis
10. ANCA and predicting relapse in systemic vasculitis
11. Titration of antibodies against neutrophil cytoplasmic antigens is useful in monitoring disease activity in systemic vasculitides
12. Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with Wegener's granulomatosis
13. Rise in ANCA titer: To treat or not to treat
14. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro
15. Antibodies against granule proteins activate neutrophils in vitro
16. Interference of Wegener's granulomatosis autoantibodies with neutrophil proteinase 3 activity
17. Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis
18. Relevance of classic anti-neutrophil cytoplasmic autoantibody (C-ANCA)-mediated inhibition of proteinase 3-alpha 1-antitrypsin complexation to disease activity in Wegener's granulomatosis
19. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis: A predominant role for the IgG3 subclass of ANCA
20. Antineutrophil cytoplasmic autoantibodies in Wegener's granulomatosis recognize conformational epitope(s) on proteinase 3
21. Epitope mapping of anti-proteinase 3 and anti-myeloperoxidase antibodies
22. Epitopes on proteinase-3 recognized by antibodies from patients with Wegener's granulomatosis
23. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis
24. Prevention of relapses in Wegener's granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre
25. Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis: Dutch Co-Trimoxazole Wegener Study Group
26. Delineation of a standard procedure for indirect immunofluorescence detection of ANCA
27. A technical note on the routinely performed ANCA detection
28. Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis
29. Differential B- and T-cell activation in Wegener's granulomatosis
30. Cleavage and inactivation of human C1 inhibitor by the human leukocyte proteinase, proteinase 3
31. Characterization of monoclonal antibodies to proteinase-3 and application in the study of epitopes for classical anti-neutrophil cytoplasm antibodies
32. Capture-ELISA based on recombinant PR3 is sensitive for PR3-ANCA testing and allows detection of PR3 and PR3-ANCA/PR3 immune complexes
33. Characterization of monoclonal antibodies to proteinase 3 as candidate tools for epitope mapping of human anti-proteinase 3 autoantibodies
34. Wegener autoantigen and myeloblastin are encoded by a single mRNA
35. Heat shock protein T cell epitopes as immunogenic carriers in subunit vaccines
36. Cloning of cDNA for proteinase 3: A serine protease, antibiotic, and autoantigen from human neutrophils
37. Donor-recipient polymorphism of the proteinase 3 gene: A potential target for T-cell alloresponses to myeloid leukemia
38. Protein thiolation and reversible protein-protein conjugation: N-succinimidyl 3-(2-pyridyldithio) propionate, a new heterobifunctional reagent
39. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies
40. Identification of protein coding regions by database similarity search
41. Primary structure of human neutrophil elastase
42. The primary structure and elastinolytic activity of medullasin (a serine protease of bone marrow)
43. Cloning and functional expression of the murine homologue of proteinase 3: Implications for the design of murine models of vasculitis
44. Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G
45. Strategies for epitope analysis using peptide synthesis
46. Analysis of the normal human IgG antibody repertoire: Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues
47. B-cell epitope spreading in autoimmunity
48. Continuous and discontinuous protein antigenic determinants
49. Epitopes on protein antigens: Misconceptions and realities
50. An immobilised peptide array identifies antibodies to a discontinuous epitope in the extracellular domain of the bovine growth hormone receptor
51. Epitope mapping of preS2 of the hepatitis B virus surface antigen against a conformation-dependent monoclonal antibody using synthetic peptides
52. Mapping B cell epitopes in Goodpasture's disease