Gene expression profiling of exposure to TZT-1027, a novel microtubule-interfering agent, in non-small cell lung cancer PC-14 cells and astrocytes

Investigational New Drugs

Volumn 19, Issue 4, 2001, Pages 293-301

  Natsume, Tsugitaka ^a,b   Nakamura, Takashi ^a   Koh, Yasuhiro ^a   Kobayashi, Motohiro ^b   Saijo, Nagahiro ^a   Nishio, Kazuto ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b Grelan Pharmaceutical Co Ltd   (Japan)

Author keywords

An antimitotic agent; Astrocytes; CDNA array; Lung cancer; TZT 1027

Indexed keywords

AURISTATIN PE; CYTOKERATIN 8; CYTOKINE; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTROCYTE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA MICROARRAY; DRUG MECHANISM; DRUG POTENCY; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MICROTUBULE ASSEMBLY; NEUROTOXICITY; PRIORITY JOURNAL;

EID: 0034862070     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010605625538     Document Type: Article

References (13)

1. Synthesis and antitumor activity of novel dolastatin 10 analogs
2. Antitumor activity of TZT-1027, a novel dolastatin 10 derivative
3. Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin
4. Induction of apoptosis in human cancer cells by TZT-1027, an antimicrotubule agent
5. Bcl-2 is the guardian of microtubule integrity
6. Raf-1/Bcl-2 phosphorylation: A step from microtubule damage to cell death
7. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
8. Use of a cDNA microarray to analyze gene expression patterns in human cancer
9. Genomics and array technology
10. High throughput analysis of differential gene expression
11. Involvement of microtubules in the control of adhesion-dependent signal transduction
12. Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: Possible involvement of the rho signal cascade
13. NGF prevention of neurotoxicity induced by cisplatin, vincristine and taxol depends on toxicity of each drug and NGF treatment schedule: In vitro study of adult rat sympathetic ganglion explants