Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells

Infection and Immunity

Volumn 70, Issue 1, 2002, Pages 268-276

  Nassar, H ^a   Chou, H H ^a   Khlgatian, M ^a   Gibson III, F C ^a   Van Dyke, T E ^a   Genco, C A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CHEMOKINE; CYSTEINE PROTEINASE; GINGIPAIN K; INTERLEUKIN 8; LYSINE; MONOCYTE CHEMOTACTIC PROTEIN; PROTEINASE INHIBITOR; RIBONUCLEASE; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; CELL INVASION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME MECHANISM; EPIDEMIOLOGICAL DATA; FIMBRIA; HOST CELL; HUMAN; HUMAN CELL; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE;

ADHESINS, BACTERIAL; AMINO ACID SEQUENCE; BACTERIAL ADHESION; BACTERIAL PROTEINS; CELLS, CULTURED; CHEMOKINE CCL2; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOTHELIUM, VASCULAR; ESCHERICHIA COLI; FIMBRIAE PROTEINS; GENE EXPRESSION; HEATING; HEMAGGLUTININS; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; LYSINE; MOLECULAR SEQUENCE DATA; PEPTIDES; PILI, SEX; PORPHYROMONAS GINGIVALIS; TRANSCRIPTION, GENETIC;

EID: 0036138101     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.1.268-276.2002     Document Type: Article

References (49)

1. Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease
2. Fimbriae-mediated host-pathogen cross-talk
3. Association between extent of periodontal attachment loss and self-reported history of heart attack: An analysis of NHANES III data
4. Periodontal disease and cardiovascular disease
5. Periodontitis: A risk factor for coronary heart disease?
6. Effects of P. gingivalis infection on atheroma formation in ApoE(+/-) Mice
7. Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis
8. Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis
9. Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator
10. Invasion strategies of the oral pathogen Porphyromonas gingivalis: Implications for cardiovascular disease
11. Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis
12. Immunologic activity of lipopolysaccharides released from macrophages after the uptake of intact E. coli in vitro
13. Interactions between periodontopathogenic bacteria and cytokines
14. Role of gingipains R in the pathogenesis of Porphyromonas gingivalis- mediated periodontal disease
15. Periodontal disease and risk for myocardial infection and cardiovascular disease
16. Chemokines and disease
17. Chemokines, a family of chemotactic cytokines
18. Identification of periodontal pathogens in atheromatous plaques
19. Type 1 fimbriae deliver an LPS- and TLR4-dependent activation signal to CD14-negative cells
20. P fimbriae-dependent, lipopolysaccharide-independent activation of epithelial cytokine responses
21. Interleukin-8 and intercellular adhesion molecule 1 regulation in oral epithelial cells by selected periodontal bacteria: Multiple effects of Porphyromonas gingivalis via antagonistic mechanisms
22. Monocyte chemoattractant protein 1 and interleukin-8 production in mononuclear cells stimulated by oral microorganisms
23. Purification and characterization of a novel arginine-specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis
24. Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes
25. Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells
26. Chronic infections and the risk of carotid atherosclerosis: Prospective results from a large population study
27. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients
28. Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats
29. Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: Implications for pathogenicity of periodontal disease
30. Pathogenesis of atherosclerosis: A possible relation to infection
31. Periodontitis-atherosclerosis syndrome: An expanded model of pathogenesis
32. The potential protective immune responses to synthetic peptides containing conserved epitopes of Porphyromonas gingivallis fimbrial protein
33. Hemagglutinating and chemotactic properties of synthetic peptide segments of fimbrial protein from Porphyromonas gingivalis
34. Immunobiological activities of synthetic peptide segments of fimbrial protein from Porphyromonas gingivalis
35. Antagonistic effect of synthetic peptides corresponding to the binding regions within fimbrial subunit protein from Porphyromonas gingivalis to human gingival fibroblasts
36. Humoral and cellular immune responses to the fimbriae of Porphyromonas gingivalis and their synthetic peptides
37. Porphyromonas gingivalis fimbriae and their synthetic peptides induce proinflammatory cytokines in human peripheral blood monocyte cultures
38. Mapping of murine Th1 and Th2 helper T-cell epitopes on fimbriae from Porphyromonas gingivalis
39. Contact-dependent protein secretion in Porphyromonas gingivalis
40. The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain
41. Intragingival occurrence of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis in active destructive periodontal lesions
42. Cytokine responses of oral epithelial cells to Porphyromonas gingivalis infection
43. The bacterial etiology of destructive periodontal disease: Current concepts
44. Role of the amino-terminal region of Porphyromonas gingivalis fimbriae in adherence to epithelial cells
45. Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis
46. Bacterial lipopolysaccharide: Extraction with phenol water and further applications of the procedure
47. Periodontal disease and risk of cerebrovascular disease: The first national health and nutrition examination survey and its follow-up study
48. Intergeneric communication in dental plaque biofilms