Role of gingipains R in the pathogenesis of Porphyromonas gingivalis - Mediated periodontal disease

Clinical Infectious Diseases

Volumn 28, Issue 3, 1999, Pages 456-465

  Genco, Caroline Attarde ^a,b,c   Potempa, Jan ^a,b,c   Mikolajczyk Pawlinska, Jowita ^a,b,c   Travis, James ^a,b,c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GINGIPAIN R;

BACTERIAL VIRULENCE; CONFERENCE PAPER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME RELEASE; NONHUMAN; PATHOGENESIS; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL;

EID: 0033014560     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/515156     Document Type: Conference Paper

References (67)

1. 1. Williams R. Periodontal disease. N Engl J Med 1990;322:373-82.
2. 2. Holt SC, Ebersole J, Felton C, Brunsvold M, Komman KS. Implantation of Bacteroides gingivalis in non-human primates initiates progression of periodontitis. Science 1988;239:55-7.
3. 3. Cutler CW, Kalmar JR, Genco CA. Pathogenic strategies of the oral anaerobe Porphyromonas gingivalis. Trends Microbiol 1995;3:45-51.
4. 4. Potempa J, Pike R, Travis J. Host and Porphyromonas gingivalis proteinases (gingipains) in periodontitis: a biochemical model of infection and tissue destruction. Prospects in drug discovery and design. 1995:445-58.
5. 5. Potempa J, Pavloff N, Travis J. Porphyromonas gingivalis: a proteinase/ gene accounting audit. Trends Microbiol 1995;3:430-4.
6. 6. Pike R, McGraw W, Potempa J, Travis J. Lysine-and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization and evidence for the existence of complexes with hemagglutinins. J Biol Chem 1994;269:406-11.
7. 7. Okamoto K, Kadowaki T, Nakamya K, Yamamoto K. Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-gingipain) in Porphyromonas gingivalis: structural relationship with the arginine-specific cysteine proteinase (arg-gingipain). J Biochem 1996;120:398-406.
8. 8. Nakayama K, Kadowaki T, Okamoto K, Yamamoto K. Construction and characterization of arginine-specific cysteine proteinase (arg-gingipain)-deficient mutants of Porphyromonas gingivalis. J Biol Chem 1995;270:23619-26.
9. 9. Seifert HS, So M. Genetic mechanisms of bacterial variation. Microbiol Rev 1988;52:327-36.
10. 10. Wang CY, Bond VC, Genco CA. Identification of a second endogenous Porphyromonas gingivalis insertion sequence. J Bacteriol 1997;179: 3808-12.
11. 11. Barkocy-Gallagher GA, Han N, Patti JM, Whitlock J, Progulske-Fox A, Lantz MS. Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis. J Bacteriol 1996;178: 2734-41.
12. 12. Galas DJ, Chandler M. Bacterial insertion sequences. In: Berg DE, Howe MM, eds. Mobile DNA. Washington, DC: American Society for Microbiology, 1989:109-62.
13. 13. Ajioka JW, Hartl DL. Population dynamics of transposable elements. In: Berg DE, Howe MM, eds. Mobile DNA. Washington, DC: American Society for Microbiology, 1989:939-58.
14. 14. Mikolajczyk-Pawlinska J, Kordula T, Pavloff N, et al. Genetic variations of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity. Biol Chem 1998;237:205-11.
15. 15. Nakayama K. Domain-specific rearrangement between the two arg-gingipain-encoding genes in Porphyromonas gingivalis: possible involvement of nonreciprocal recombination. Microbiol Immunol 1997;41: 185-96.
16. 16. Potempa J, Pike R, Travis J. The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either arg-gingipain of Lys-gingipain. Infect Immun 1995; 63:1176-82.
17. 17. Chen Z, Potempa J, Polanowski A, Wikstrom M, Travis J. Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis. J Biol Chem 1992;267:18896-901.
18. 18. Ciborowski P, Nishikata M, Allen RD, Lantz MS. Purification and characterization of two forms of a high-molecular-weight cysteine proteinase (porphypain) from Porphyromonas gingivalis. J Bacteriol 1994;176: 1549-57.
19. 19. Pavloff N, Pemberton PA, Potempa J, et al. Molecular cloning and characterization of Porphyromonas gingivalis Lys-gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases. J Biol Chem 1997;272:1595-600.
20. 20. Nishikata M, Yoshimura F. Active site structure of a hemagglutining protease from Porphyromonas gingivalis: similarity to clostripain. Biochem Mol Biol Int 1995;37:547-53.
21. 21. Han N, Whitlock J, Progulske-Fox A. The hemagglutinin gene (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats. Infect Immun 1996;64:4000-7.
22. 22. Westerlund B, Korhonen TK. Bacterial proteins binding to the mammalian extracellular matrix. Mol Microbiol 1993;9:687-94.
23. 23. Curtis MA, Aduse-Opoku J, Slaney JM, et al. Characterization of an adherence and antigenic determinant of the ArgI protease of Porphyromonas gingivalis which is present on multiple gene products. Infect Immun 1996;64:2532-9.
24. 24. Kelly CG, Booth V, Kendal H, Slaney JM, Curtis MA, Lehner T. The relationship between colonization and haemaggiutination inhibiting and B cell epitopes of Porphyromonas gingivalis. Clin Exp Immunol 1997; 110:285-91.
25. 25. Jose J, Jahnig F, Meyer TF. Common structural features of IgA1 protease-like outer membrane protein autotransporters. Mol Microbiol 1995;18: 377-82.
26. 26. Klauser TM, Pohlner J, Meyer TF. The secretion pathway of IgA protease-type proteins in gram-negative bacteria. Bioassays 1993;15:799-805.
27. 27. Finlay BB, Falkow S. Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 1997;61:136-69.
28. 28. Rangarajan M, Aduse-Opoku J, Slaney JM, Young KA, Curtis M. The prpR1 and prpR2 arginine-specific protease genes of Porphyromonas gingivalis W50 produce five biochemically distinct enzymes. Mol Microbiol 1997;23:955-65.
29. 29. Chou PY, Fasman GD. Prediction of the secondary structure of proteins from their amino acid sequence. In: Meister A, ed. Advances in enzymology. New York: Wiley & Sons, 1978:45-148.
30. 30. Pohlner J, Halter R, Beyreuther K, Meyer TF. Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature 1978; 325:458-62.
31. 31. Klauser T, Kramer J, Otzelberger K, Pohlner J, Meyer TF. Characterization of the Neisseria IgA alpha-core: the essential unit for outer membrane targeting and extracellular secretion. J Mol Biol 1993;234:579-93.
32. 32. Yanagida N, Uozumi T, Beppu T. Specific extraction of Serratia marcescens protease through the outer membrane. J Bacteriol 1986;166: 937-44.
33. 2 and COOH-terminal prosequences and its processing in Escherichia coli. J Biol Chem 1990;256:6576-81.
34. 34. Imamura T, Pike RN, Potempa J, Travis J. Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway. J Clin Invest 1994;94:361-7.
35. 35. Imamura T, Potempa J. Pike RE, Travis J. Dependence of vascular permeability enhancement on cysteine proteinases in vesicles of Porphyromonas gingivalis. Infect Immun 1995;63:1999-2003.
36. 36. Wingrove JA, DiScipio RG, Chen Z, Potempa J, Travis J, Hugli TE. Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas gingivalis. J Biol Chem 1992; 267:18902-7.
37. 37. Discipio RG, Daffem PJ, Kawahara M, Pike R, Travis J, Hugli TE. Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas gingivalis. Prior oxidation of C5 augments proteinase digestion of C5. Immunology 1996;87:660-7.
38. 38. Overall CM, Sodek J, McCulloch CAG, Birek P. Evidence for polymorphonuclear leukocyte collagenase and 92-kilodalton gelatinase in gingival crevicular fluid. Infect Immun 1991;59:4687-92.
39. 39. Cox SW, Eley BM. Cathepsin B/L, elastase, tryptase, trypsin, and dipeptydyl peptidase IV-like activities in gingival crevicular fluid: a comparison of the level before and after basic periodontal treatment of chronic periodontitis patients. J Clin Periodontol 1992;19:333-9.
40. 40. Gustafsson A, Asman B, Bergstrom K, Soder P-O. Granulocyte elastase in gingival crevicular fluid: a possible discriminator between gingivitis and periodontitis. J Clin Periodontol 1992;10:535-40.
41. 41. Giannopoulou C, Anderson E, Demeurisse C, Cimasoni G. Neutrophil elastase and its inhibitors in human gingival crevicular fluid during experimental gingivitis. J Dent Res 1992;71:359-363.
42. 42. Kontani M, Ono H, Shibata H, et al. Cysteine protease of Porphyromonas gingivalis 381 enhances binding of fimbriae to cultured human fibroblasts and matrix proteins. Infect Immun 1996;64:756-62.
43. 43. Takahisa I, Potempa J, Tanase S, Travis J. Activation of blood coagulation factor X by arginine-specific cysteine proteinases (gingipain Rs) from Parphyromonas gingivaux. J Biol Chem 1997;272:16062-7.
44. 44. Scott CF, Whitlaker EJ, Hammond BF, Colman RW. Purification and characterization of a potent 70-kDa thiol lysyl-proteinase (Lys-gingivain) from Porphyromonas gingivalis that cleaves kininogens and fibrinogen. J Biol Chem 1993;268:7935-42.
45. 45. Shah HN, Gharbia SE. Lysis of erythrocytes by the secreted cysteine proteinase of Porphyromonas gingivalis W83. FEMS Microbiol Lett 1989;61:213-8.
46. 46. Genco CA, Cutler CW, Kapczynski DR, Maloney KM, Arnold RR. A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect Immun 1991;59: 1255-63.
47. 47. Genco CA, Arko RJ. Animal chamber models for the study of host-parasite interactions. Bacterial pathogenesis, part A: identification and regulation of virulence factors. Methods Enzymol 1993;235:120-40.
48. 48. Potempa J, Pike R, Travis J. Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes. J Biol Chem 1997;378:223-30.
49. 49. Fletcher HM, Schenkein HA, Morgan RM, Bailey KA, Berry CR, Macrina FL. Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene. Infect Immun 1995;63:1521-8.
50. 50. Nakayama KM, Yoshimura F, Kadowaki T, Yamamoto K. Involvement of arginine-specific cysteine proteinases (arg-gingipain) in fimbriation of Porphyromonas gingivalis. J Bacteriol 1996;178:2818-24.
51. 51. Onoe T, Hoover CI, Nakayama K, Ideka T, Nakamura H, Yoshimura F. Identification of Porphyromonas gingivalis prefimbrillin possessing a long leader peptide: possible involvement of trypsin-like protease in fimbrillin maturation. Microb Pathogen 1995;19:351-64.
52. 52. Kontani M, Ono H, Shibata H, et al. Cysteine protease of Porphyromonas gingivalis 381 enhances binding of fimbriae to cultured human fibroblasts and matrix proteins. Infect Immun 1996;64:756-62.
53. 53. Tokuda M, Duncan M, Cho M-I, Kuramitsu HK. Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces. Infect Immun 1996;64:4067-73.
54. 54. Malek R, Fisher G, Caleca A, et al. Inactivation of the Porphyromonas gingivalis fimA gene blocks periodontal damage in gnotobiotic rats. J Bacteriol 1994;176:1052-9.
55. 55. Njoroge T, Genco RJ, Sojar HT, Hamada N, Genco CA. A role for fimbriae in the adherence of Porphyromonas gingivalis to oral epithelial cells. Infect Immun 1997;65:1980-4.
56. 56. Genco CA. Regulation of hemin and iron transport in Porphyromonas gingivalis. Adv Dent Res 1995;9:41-7.
57. 57. McArthur WP, Clark WB. Specific antibodies and their potential role in periodontal diseases. J Periodontol 1993;64:807-18.
58. 58. Ebersole JL, Taubman MA, Smith DJ, Frey DE, Haffajee AD, Socransky SS. Human serum antibody responses to oral microorganisms. IV. Correlation with homologous infection. Oral Microbiol Immunol 1987;2: 53-9.
59. 59. Gunsolley JC, Tew JG, Gooss C, Marshall DR, Burmeister JA, Schenkein HA. Serum antibodies to periodontal bacteria. J Periodontol 1990;61: 412-9.
60. 60. Naito Y, Okuda K, Takazoe I. Detection of specific antibody in adult human periodontitis sera to surface antigens of Bacteroides gingivalis. Infect Immun 1987;55:832-4.
61. 61. Schenck K. IgG, IgA, and IgM serum antibodies against lipopolysaccharide from Bacteroides gingivalis in periodontal health and disease. J Periodontol Res 1985;20:368-77.
62. 62. Turner DW, Dai GJ, Merrell B, Robinson JP. Serum and gingival tissue antibody levels to oral microbial antigens in human chronic adult periodontitis. Microbios 1989;60:133-40.
63. 63. Yoshimura F, Sugano T, Kawanami M, Kato H, Suziki T. Detection of specific antibodies against fimbriae and membrane proteins from the oral anaerobe Bacteroides gingivalis in patients with periodontal disease. Microbiol Immunol 1987;31:935-57.
64. 64. Genco CA, Odusanya BM, Potempa J, Mikolajczyk-Pawlinska J, Travis J. A peptide domain on gingipain R1 which confers immunity against Porphyromonas gingivalis infection in mice. Infect Immun 1998;66: 4108-14.
65. 65. Aduse-Opoku J, Slaney J, Rangarajan M, Muir J, Young K, Curtis MA. The T1a protein of Porphyromonas gingivalis W50: a homolog of the R1 protease precursor (PrpR1) is an outer membrane receptor required for growth on low levels of hemin. J Bacteriol 1997;179:4778-88.
66. 66. Progulske-Fox A, Tumwasorn S, Lepine G, et al. The cloning, expression and sequence analysis of a second Porphyromonas gingivalis gene that codes for a protein involved in hemagglutination. Oral Microbiol Immunol 1995;10:311-8.
67. 67. Patti JM, Allen BL, McGavin MJ, Hook M. MSCRAMM-mediated adherence of microorganisms to host tissues. Ann Rev Microbiol 1994;48: 585-617.