Glycine antagonist and NO°synthase inhibitor protect the developing mouse brain against neonatal excitotoxic lesions

Pediatric Research

Volumn 45, Issue 3, 1999, Pages 337-342

  Marret, Stéphane ^a,c,d   Bonnier, Christine ^b   Raymackers, Jean Marc ^b   Delpech, Annie ^a   Evrard, Philippe ^c   Gressens, Pierre ^c  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^c HÔPITAL ROBERT DEBRÉ   (France)

^d HÔPITAL CHARLES NICOLLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; EXCITOTOXIN; GLYCINE RECEPTOR ANTAGONIST; IBOTENIC ACID; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; AMINO ACID RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; GLUTAMIC ACID; GLYCINE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN PROTECTION; CONTROLLED STUDY; INTRACEREBRAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NERVE CELL NECROSIS; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; PATHOPHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; BRAIN; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; HUMANS; KYNURENIC ACID; MICE; NITRIC OXIDE SYNTHASE; NITROARGININE;

EID: 0032588509     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199903000-00008     Document Type: Article

References (45)

1. Banker B, Larroche JC 1962 Periventricular leukomalacia of infancy; a form of neonatal anoxic encephalopathy. Arch Neurol 7:386-410
2. Nelson KB, Ellenberg JW 1986 Antecedents of cerebral palsy: multivariate analysis of risk. N Engl J Med 315:81-86
3. Evrard P, Marret S, Gressens P 1997 Environmental and genetic determinants of neural migration and postmigratory survival. Acta Paediatr Scand Suppl 422:20-26
4. Murphy DJ, Sellers S, MacKenzie IZ, Yudkin PL, Johnson AM 1995 Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies. Lancet 346:1449-1454
5. Zupan V, Gonzalez P, Lacaze-Masmonteil T, Boithias C, d'Allest AM, Dehan M, Gabilan JC 1996 Periveritricular ieukomalaeia: risk factors revisited. Dev Med Child Neurol 38:1061-1067
6. Marin-Padilla M 1997 Developmental neuropathology and impact of perinatal brain damage: II. white matter lesions of the neocortex. J Neuropathol Exp Neurol 56:219-235
7. Ikonomidou C, Mosinger JL, Shahid Salles K, Labruyere J, Olney JW 1989 Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate toxicity. J Neurosci 9:2809-2818
8. McDonald JW, Johnston MV 1990 Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Rev 15:41-70
9. Lipton SA, Rosenberg PA 1994 Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622
10. Gilles FH, Averili D, Kerre CS 1977 Neonatal endotoxin encephalopathy, Ann Neurol 2:49-56
11. Yoon BH, Kim CJ, Romero R, Jun JK, Park KH, Choi ST, Chi JG 1997 Experimentally induced intrauterinc infection causes fetal brain white matter lesions in rabbits. Am J Obstet Gynecol 177:797-802
12. Yoshioka H, Goma H, Nioka S, Ochi M, Miyake M, Zaman A 1994 Bilateral carotid occlusion causes periventricuiar feukomalacia in neonatal dogs. Dev Brain Res 78:273-278
13. Oka A, Beliveau MJ, Rosenberg PA, Volpe JJ 1993 Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci 13:1441-1453
14. McDonald JW, Althomsons SP, Hyre KL, Choi DW, Goldberg MP 1998 Oligodendrocyles are highly Vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nature Med 4:291-297
15. Volpe JJ 1995 Neurology of the newborn. WB Saunders, Philadelphia, pp 279-313
16. Marret S, Mukendi R, Gadisseux JF, Gressens P, Evrard P 1995 Effect of ibotenate on brain development: an excitotoxic mouse model of microgyria and posthypoxiclike lesions. J Neuropathol Exp Neurol 54:358-370
17. Marret S, Gressens P, Gadisseux JF, Evrard P 1995 Prevention by magnesium of excitotoxic neuronal death in the developing brain: an animal model for the clinical intervention studies. Dev Med Child Neurol 37:473-484
18. Marret S, Gressens P, Evrard P 1996 Arrest of neuronal migration by excitatory 1 amino acids in hamster developing brain. Proc Natl Acad Sci USA 93:15463-15468
19. Vannucci RC, Perlman JM 1997 Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 100:1004-1014
20. Bac P, Maurois P, Dupont C, Pages N, Stables JP, Gressens P, Evrard P, Vamecq J 1998 Magnesium-deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvutsant drugs and original assessment of neuroprotection properties. J Neurosci 18:4363-4373
21. Gressens P, Marret S, Hill JM, Brenneman DE, Gozes I, Fridkin M 1997 Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain, J Clin Invest 100:390-397
22. Gunn AJ, Gunn TR, de Haan HH, Williams CE, Gluckman PD 1997 Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest 99:248-256
23. Edwards AD, Wyatt JS, Thoresen M 1998 Treatment of hypoxic-ischemic brain damage by moderate hypothermia. Arch Dis Child 78:F85-F91
24. Watanabe M, Inoue Y, Sakimura K, Mishina M 1992 Developmental change in distribution of NMDA receptor channel subunit. Neuroreport 3:1138-1140
25. Zukin RS, Bennett MVL 1995 Alternative spliced isoforms of the NMDARI receptor submit. TINS 18:306-313
26. Wenzel, Fritschy JM, Mohler H, Senke D 1997 NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins. J Neurochem 68:469-478
27. Beal MF, Swartz KJ, Isacson O 1992 Developmental changes in brain kynurenic concentration. Dev Brain Res 68:136-139
28. Ceresoli G, Füller MS, Scwarcz R 1996 Excitotoxic lesions of the rat striatum: different responses of kynurenine pathway enzymes during ontogeny. Dev Brain Res 96:61-69
29. Andiné P, Lehman A, Ellren K, Wennberg E, Kjellmer I, Nielsen T, Hagberg H 1988 The excitatory amino acid antagonist kynurenic acid administered after hypoxic ischemia in neonatal rats offers neuroprotection. Neurosci Lett 90:208-212
30. Dawson TM, Dawson V, Snyder SH 1992 A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann Neurol 32:297-311
31. G-nitroarginine, a novel, L-arginine-reversible inhibition of endothelium-dependent vasodilatation in vitro. Br J Pharmacol 99:408-412
32. G-nitroarginine in brain In vitro and in vivo. Biochem Biophys Res Commun 176:1136-1141
33. Lizasoain I, Weiner CP, Knowles RG, Moncada S 1996 The ontogeny of cerebral and cerebellar nitric oxide synthase in the guinea pig and rat. Pediatr Res 39:779-783
34. Buchan AM, Gertler SZ, Huang ZG, Li H, Chaundy KE, Xue D 1994 Failure to prevent selective CA1 neuronal death and reduce cortical infarction following cerebral ischemia with inhibition of nitric oxide synthase. Neuroscience 61:1-11
35. Hamada Y, Hayakawa T, Hattori H, Mikawa H 1994 Inhibitor of nitric oxide synthesis reduces hypoxic-ischemic brain damage in the neonatal rat. Pediatr Res 35:10-14
36. Dorrepaal CA, Shadid M, Steedijk P, van der Velde ET, Meinesz JH, van der Bor M, Baan J. van Bel F 1995 Prevention of postasphyxial brain injury by NG-nitro-L-arginine [Abstract]. Pediatr Res 37:377
37. Wass CT, Lanier WL, Hofer RE, Scheithauer BW, Andrews PG 1995 Temperature changes of > 1°C alter functional neurologic outcome and histopathology in a canine model of complete cerebral ischemia. Anesthesiology 83:325-335
38. Degi R, Bari F, Beasley TC, Thrikawala N, Thore C, Louis TM, Busija DW 1998 Regional distribution of prostaglandin H synthase-type 2 and neuronal nitric oxide synthase in piglet brain. Pediatr Res 43:683-689
39. Chumas PD, Debigio MR, Drake JM, Tuor UI 1993 A comparison of the protective effect of dexamethasone to other potential prophylactic agents in a neonatal rat model of cerebral hypoxia-ischcmia. J Neurosurg 79:414-420
40. Chow HS, Lynch JL, Rose K, Choï DW 1994 Trolox attenuates cortical neuronal injury induced by iron, ultraviolet light, glucose deprivation, or AMPA. Brain Res 639:102-108
41. Bagenholm R, Andiné P, Hagberg H 1996 Effects of the 21-amino steroid tirilazad mesylate (U-74006F) on brain damage and edema after perinatal hypoxia-ischemia in the rat. Pediatr Res 40:399-403
42. Dugan LL, Turetsky DM, Du C, Lobner D, Wheeler M, Almli CR, Shen CK, Luh TY, Choï DW, Lin TS 1997 Carfboxyfullerenes as neuroprotective agents. Proc Natl Acad Sci USA 94:9434-9439
43. Chen N, Moshaver A, Raymond LA 1997 Differential sensitivity of recombinant N-methyl-n-aspartate receptor subtypes to zinc inhibition. Mol Pharmacol 51:1015-1023
44. Koh J-Y, Suh SW, Gwag BJ, He YY, Hsu CY, Choï DW 1996 The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272:1013-1016
45. Zhou FM, Hablitz JJ 1993 Zinc enhances GABA-ergic transmission in rat neocortical neurons. J Neurophysiol 70:1264-1269