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Volumn 8, Issue 3, 1996, Pages 230-235

Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit

Author keywords

Dexmedetomidine; Excitatory amino acids; Global cerebral ischemia; Microdialysis; Rabbit; Adrenergic agonist

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; DEXMEDETOMIDINE; EXCITATORY AMINO ACID; GLUTAMIC ACID; GLYCINE;

EID: 0012113312     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008506-199607000-00008     Document Type: Article
Times cited : (16)

References (40)
  • 1
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • Benveniste H, Drejer J, Schousboe A, et al. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984;43: 1369-74
    • (1984) J Neurochem , vol.43 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3
  • 2
    • 0026228194 scopus 로고
    • The excitotoxin hypothesis in relation to cerebral ischemia
    • Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovasc Brain Metab Rev 1991;3: 213-45.
    • (1991) Cerebrovasc Brain Metab Rev , vol.3 , pp. 213-245
    • Benveniste, H.1
  • 4
    • 0024460534 scopus 로고
    • Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3
    • Benveniste H, Jorgensen MB, Sandberg M, et al. Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3. J Cereb Blood Flow Metab 1989;9:629-39.
    • (1989) J Cereb Blood Flow Metab , vol.9 , pp. 629-639
    • Benveniste, H.1    Jorgensen, M.B.2    Sandberg, M.3
  • 5
    • 0021916489 scopus 로고
    • Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path
    • Wieloch T, Lindvall O, Blomqvist P, et al. Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path. Neurol Res 1985;7:24-6.
    • (1985) Neurol Res , vol.7 , pp. 24-26
    • Wieloch, T.1    Lindvall, O.2    Blomqvist, P.3
  • 6
    • 0026585041 scopus 로고
    • Glycine is required for NMDA receptor activation: Electrophysiological evidence from intact rat hippocampus
    • Dalkara T, Erdemli G, Barun S, et al. Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus. Brain Res 1992;576:197-202.
    • (1992) Brain Res , vol.576 , pp. 197-202
    • Dalkara, T.1    Erdemli, G.2    Barun, S.3
  • 7
    • 0023754192 scopus 로고
    • Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
    • Kleckner NW, Dingledine R. Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science 1988;241:835-7.
    • (1988) Science , vol.241 , pp. 835-837
    • Kleckner, N.W.1    Dingledine, R.2
  • 8
    • 0023091647 scopus 로고
    • Glycine potentiates the NMDA response in cultured mouse brain neurons
    • Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 1987;325: 529-31.
    • (1987) Nature , vol.325 , pp. 529-531
    • Johnson, J.W.1    Ascher, P.2
  • 9
    • 0024564769 scopus 로고
    • Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices
    • Thomson AM, Walker VE, Flynn DM. Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices. Nature 1989;338:422-4.
    • (1989) Nature , vol.338 , pp. 422-424
    • Thomson, A.M.1    Walker, V.E.2    Flynn, D.M.3
  • 10
    • 0023683517 scopus 로고
    • Glycine potentiates strychnine-induced convulsions: Role of NMDA receptors
    • Larson AA, Beitz AJ. Glycine potentiates strychnine-induced convulsions: role of NMDA receptors. J Neurosci 1988;8:3822-6.
    • (1988) J Neurosci , vol.8 , pp. 3822-3826
    • Larson, A.A.1    Beitz, A.J.2
  • 11
    • 0025994323 scopus 로고
    • Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain
    • Baker AJ, Zornow MH, Scheller MS, et al. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain. J Neurochem 1991; 57:1370-9.
    • (1991) J Neurochem , vol.57 , pp. 1370-1379
    • Baker, A.J.1    Zornow, M.H.2    Scheller, M.S.3
  • 12
    • 0021396341 scopus 로고
    • Distribution of alpha-2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents
    • Unnerstall JR, Kopajtic TA, Kuhar MJ. Distribution of alpha-2 agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Res 1984;319:69-101.
    • (1984) Brain Res , vol.319 , pp. 69-101
    • Unnerstall, J.R.1    Kopajtic, T.A.2    Kuhar, M.J.3
  • 13
    • 0021742239 scopus 로고
    • Mapping receptors for alpha-2 agonists in the central nervous system
    • Kuhar MJ, Unnerstall JR. Mapping receptors for alpha-2 agonists in the central nervous system. J Cardiovasc Pharmacol 1984;6:S536-42.
    • (1984) J Cardiovasc Pharmacol , vol.6
    • Kuhar, M.J.1    Unnerstall, J.R.2
  • 14
    • 0024153323 scopus 로고
    • Clonidine and other alpha-2 adrenergic agonists: Strategies for the rational use of these novel anesthetic agents
    • Maze M, Segal IS, Bloor BC. Clonidine and other alpha-2 adrenergic agonists: strategies for the rational use of these novel anesthetic agents. J Clin Anesth 1988;1:146-57.
    • (1988) J Clin Anesth , vol.1 , pp. 146-157
    • Maze, M.1    Segal, I.S.2    Bloor, B.C.3
  • 15
    • 0023803045 scopus 로고
    • Anesthetic and hemodynamic effects of the stereoisomers of medetomidine, an alpha-2 adrenergic agonist, in halothane-anesthetized dogs
    • Vickery RG, Sheridan BC, Segal IS, et al. Anesthetic and hemodynamic effects of the stereoisomers of medetomidine, an alpha-2 adrenergic agonist, in halothane-anesthetized dogs. Anesth Analg 1988;67:611-15.
    • (1988) Anesth Analg , vol.67 , pp. 611-615
    • Vickery, R.G.1    Sheridan, B.C.2    Segal, I.S.3
  • 16
    • 0024241512 scopus 로고
    • Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha-2 adrenergic receptor
    • Segal IS, Vickery RG, Walton JK, et al. Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha-2 adrenergic receptor. Anesthesiology 1988;69:818-23.
    • (1988) Anesthesiology , vol.69 , pp. 818-823
    • Segal, I.S.1    Vickery, R.G.2    Walton, J.K.3
  • 17
    • 0023429393 scopus 로고
    • Sedative and cardiovascular effects of medetomidine, a novel selective alpha-2 adrenoceptor agonist, in healthy volunteers
    • Scheinin M, Kallio A, Koulu M, et al. Sedative and cardiovascular effects of medetomidine, a novel selective alpha-2 adrenoceptor agonist, in healthy volunteers. Br J Clin Pharmacol 1987;24:443-51.
    • (1987) Br J Clin Pharmacol , vol.24 , pp. 443-451
    • Scheinin, M.1    Kallio, A.2    Koulu, M.3
  • 18
    • 0025930833 scopus 로고
    • Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole
    • Hoffman WE, Kochs E, Werner C, et al. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology 1991;75:328-32.
    • (1991) Anesthesiology , vol.75 , pp. 328-332
    • Hoffman, W.E.1    Kochs, E.2    Werner, C.3
  • 19
    • 0027248053 scopus 로고
    • Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia
    • Maier C, Steinberg GK, Sun GH, et al. Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology 1993;79: 306-12.
    • (1993) Anesthesiology , vol.79 , pp. 306-312
    • Maier, C.1    Steinberg, G.K.2    Sun, G.H.3
  • 20
    • 0027371371 scopus 로고
    • The alpha-2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations
    • Matsumoto M, Zornow MH, Rabin BC, et al. The alpha-2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain Res 1993;627:325-9.
    • (1993) Brain Res , vol.627 , pp. 325-329
    • Matsumoto, M.1    Zornow, M.H.2    Rabin, B.C.3
  • 21
    • 0025873453 scopus 로고
    • Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits
    • Baker AJ, Zornow MH, Grafe MR, et al. Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits. Stroke 1991;22:666-73.
    • (1991) Stroke , vol.22 , pp. 666-673
    • Baker, A.J.1    Zornow, M.H.2    Grafe, M.R.3
  • 22
    • 0024377189 scopus 로고
    • Direct evidence for acute and massive norepinephrine release in the hippocampus during transient ischemia
    • Globus MY, Busto R, Dietrich WD, et al. Direct evidence for acute and massive norepinephrine release in the hippocampus during transient ischemia. J Cereb Blood Flow Metab 1989;9:892-6.
    • (1989) J Cereb Blood Flow Metab , vol.9 , pp. 892-896
    • Globus, M.Y.1    Busto, R.2    Dietrich, W.D.3
  • 23
    • 0025360957 scopus 로고
    • Ischemia in the dorsal hippocampus is associated with acute extracellular release of dopamine and norepinephrine
    • Bhardwaj A, Brannan T, Martinez-Tica J, et al. Ischemia in the dorsal hippocampus is associated with acute extracellular release of dopamine and norepinephrine. J Neural Transm 1990;80:195-201.
    • (1990) J Neural Transm , vol.80 , pp. 195-201
    • Bhardwaj, A.1    Brannan, T.2    Martinez-Tica, J.3
  • 24
    • 0022679881 scopus 로고
    • Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro
    • Madison DV, Nicoll RA. Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro. J Physiol 1986;372:221-44.
    • (1986) J Physiol , vol.372 , pp. 221-244
    • Madison, D.V.1    Nicoll, R.A.2
  • 25
    • 0020041444 scopus 로고
    • Cortical injury without ischemia produced by topical monoamines
    • Stein SC, Cracco RQ. Cortical injury without ischemia produced by topical monoamines. Stroke 1982;13:74-83.
    • (1982) Stroke , vol.13 , pp. 74-83
    • Stein, S.C.1    Cracco, R.Q.2
  • 26
    • 0025147157 scopus 로고
    • Ganglionic blockade improves neurologic outcome from incomplete ischemia in rats: Partial reversal by exogenous catecholamines
    • Werner C, Hoffman WE, Thomas C, et al. Ganglionic blockade improves neurologic outcome from incomplete ischemia in rats: partial reversal by exogenous catecholamines. Anesthesiology 1990;73:923-9.
    • (1990) Anesthesiology , vol.73 , pp. 923-929
    • Werner, C.1    Hoffman, W.E.2    Thomas, C.3
  • 27
    • 0022389997 scopus 로고
    • Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain
    • Blomqvist P, Lindvall O, Wieloch T. Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain. Neurosci Lett 1985;58:353-8.
    • (1985) Neurosci Lett , vol.58 , pp. 353-358
    • Blomqvist, P.1    Lindvall, O.2    Wieloch, T.3
  • 29
    • 8944247288 scopus 로고
    • Clonidine improves neurologic outcome following incomplete ischemia in rats
    • Cheng MA, Hoffman WE, Miletich DJ, et al. Clonidine improves neurologic outcome following incomplete ischemia in rats. Anesth Analg 1991;72:S39.
    • (1991) Anesth Analg , vol.72
    • Cheng, M.A.1    Hoffman, W.E.2    Miletich, D.J.3
  • 30
    • 0022524745 scopus 로고
    • Alpha-2 adrenoreceptor antagonists decrease free 3-methoxy-4-hydroxyphenylglycol in rat cerebrospinal fluid
    • Scheinin H, Virtanen R, Scheinin M. Alpha-2 adrenoreceptor antagonists decrease free 3-methoxy-4-hydroxyphenylglycol in rat cerebrospinal fluid. Eur J Pharmacol 1986;123: 115-21.
    • (1986) Eur J Pharmacol , vol.123 , pp. 115-121
    • Scheinin, H.1    Virtanen, R.2    Scheinin, M.3
  • 31
    • 0023008103 scopus 로고
    • Evidence of medetomidine as a selective and potent agonist at alpha-2 adrenoreceptors
    • Savola JM, Ruskoaho H, Puurunen J, et al. Evidence of medetomidine as a selective and potent agonist at alpha-2 adrenoreceptors. J Auton Pharmacol 1986;6:275-84.
    • (1986) J Auton Pharmacol , vol.6 , pp. 275-284
    • Savola, J.M.1    Ruskoaho, H.2    Puurunen, J.3
  • 32
    • 0024344219 scopus 로고
    • Inhibition of ischemia-induced brain catecholamine alterations by clonidine
    • Miyazaki M, Nazarali AJ, Boisvert DP, et al. Inhibition of ischemia-induced brain catecholamine alterations by clonidine. Brain Res Bull 1989;22:207-11.
    • (1989) Brain Res Bull , vol.22 , pp. 207-211
    • Miyazaki, M.1    Nazarali, A.J.2    Boisvert, D.P.3
  • 33
    • 0025172919 scopus 로고
    • Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog
    • Zornow MH, Fleischer JE, Scheller MS, et al. Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog. Anesth Analg 1990;70:624-30.
    • (1990) Anesth Analg , vol.70 , pp. 624-630
    • Zornow, M.H.1    Fleischer, J.E.2    Scheller, M.S.3
  • 34
    • 0027510650 scopus 로고
    • Dexmedetomidine decreases cerebral blood flow velocity in humans
    • Zornow MH, Maze M, Dyck JB, et al. Dexmedetomidine decreases cerebral blood flow velocity in humans. J Cereb Blood Flow Metab 1993;13:350-3.
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 350-353
    • Zornow, M.H.1    Maze, M.2    Dyck, J.B.3
  • 35
    • 0020415451 scopus 로고
    • Noradrenergic modulation of glutamate release in the cerebellum
    • Dolphin AC. Noradrenergic modulation of glutamate release in the cerebellum. Brain Res 1982;252:111-16.
    • (1982) Brain Res , vol.252 , pp. 111-116
    • Dolphin, A.C.1
  • 36
    • 0026029965 scopus 로고
    • Subtypes of adrenergic receptors and intracellular mechanisms involved in modulatory effects of noradrenaline on glutamate
    • Mori-Okamoto J, Namii Y, Tatsuno J. Subtypes of adrenergic receptors and intracellular mechanisms involved in modulatory effects of noradrenaline on glutamate. Brain Res 1991;539:67-75.
    • (1991) Brain Res , vol.539 , pp. 67-75
    • Mori-Okamoto, J.1    Namii, Y.2    Tatsuno, J.3
  • 37
    • 0027371371 scopus 로고
    • The alpha-2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations
    • Matsumoto M, Zornow M, Rabin B, et al. The alpha-2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain Res 1993;627:325-9.
    • (1993) Brain Res , vol.627 , pp. 325-329
    • Matsumoto, M.1    Zornow, M.2    Rabin, B.3
  • 38
    • 0023631632 scopus 로고
    • Inhibitory effects of noradrenaline and dopamine on calcium influx and neurotransmitter glutamate release in mammalian brain slices
    • Crowder JM, Bradford HF. Inhibitory effects of noradrenaline and dopamine on calcium influx and neurotransmitter glutamate release in mammalian brain slices. Eur J Pharmacol 1987;143:343-52.
    • (1987) Eur J Pharmacol , vol.143 , pp. 343-352
    • Crowder, J.M.1    Bradford, H.F.2
  • 39
    • 0026327740 scopus 로고
    • Clonidine inhibition of potassium-evoked release of glutamate and aspartate from rat cortical synaptosomes
    • Kamisaki Y, Hamahashi T, Okada CM, et al. Clonidine inhibition of potassium-evoked release of glutamate and aspartate from rat cortical synaptosomes. Brain Res 1991;568: 193-8.
    • (1991) Brain Res , vol.568 , pp. 193-198
    • Kamisaki, Y.1    Hamahashi, T.2    Okada, C.M.3
  • 40
    • 0023631632 scopus 로고
    • Inhibitory effects of noradrenaline and dopamine on calcium influx and neurotransmitter glutamate release in mammalian brain slices
    • Crowder J, Bradford H. Inhibitory effects of noradrenaline and dopamine on calcium influx and neurotransmitter glutamate release in mammalian brain slices. Eur J Pharmacol 1987;143:343-52.
    • (1987) Eur J Pharmacol , vol.143 , pp. 343-352
    • Crowder, J.1    Bradford, H.2


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