Endotoxin induces desensitization of cardiac endothelin-1 receptor signaling by increased expression of RGS4 and RGS16

Cardiovascular Research

Volumn 53, Issue 1, 2002, Pages 156-164

  Patten, Monica ^a   Bünemann, Jan ^a   Thoma, Bryan ^a   Krämer, Elisabeth ^a   Thoenes, Martin ^a   Stübe, Sabine ^a   Mittmann, Clemens ^a   Wieland, Thomas ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Endotoxins; G Proteins; Heart failure; Sepsis; Signal transduction

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; PHOSPHOLIPASE C; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVITY; HEART FAILURE; HEART MUSCLE CELL; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REGULATORY MECHANISM; SEPSIS; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; GTP-BINDING PROTEINS; HEART FAILURE, CONGESTIVE; LIPOPOLYSACCHARIDES; MALE; MYOCARDIUM; PHOSPHOLIPASE C; PROTEINS; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; RGS PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0036136663     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00443-6     Document Type: Article

References (36)

1. Septic shock in humans
2. Deficient production of cyclic AMP: Pharmacological evidence of an important cause of contractile dysfunction in patients with end-stage heart failure
3. Increase of the 40,000-mol wt pertussis toxin substrate (G-protein) in the failing human heart
4. Increase in myocardial Gi-proteins in heart failure
5. Increase of myocardial inhibitory G-proteins in catecholamine-refractory septic shock or in septic multiorgan failure
6. Tumor necrosis factor depresses myocardial contractility in endotoxemic swine
7. Tumor necrosis factor α up-regulates Giα and Gβ proteins and adenylyl cyclase responsiveness in rat cardiomyocytes
8. RGS proteins and signaling by heterotrimeric G proteins
9. Intracellular signalling: Turning down G-protein signals
10. Regulators of G-protein signalling: A novel protein family involved in timely deactivation and desensitization of signalling via heterotrimeric G proteins
11. Cardiac myocytes express mRNA for ten RGS proteins: Changes in RGS mRNA expression in ventricular myocytes and cultured atria
12. Expression of proteins involved in Gq/G11 mediated signalling in human myocardium
13. Subtype specific upregulation of RGS proteins in failing human ventricular myocardium
14. Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes
15. Apparent upregulation of stimulatory G-protein α-subunits in the pregnant myometrium is mimicked by elevated smouthelin expression
16. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
17. 1-adrenergic induced gene expression in cultured cardiac myocytes
18. A role for Rho in receptor- and G protein-stimulated phospholipase C. Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B
19. Desensitization of cardiac β-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins
20. Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling
21. 1a receptor to different G proteins
22. RGS3 and RGS4 are GTPase activating proteins in the heart
23. α2 results in translocation of cytoplasmic RGS4 to the plasma membrane
24. RGS4 inhibits G-protein signaling in cardiomyocytes
25. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload
26. Endothelin receptors in the human coronary artery, ventricle and atrium
27. Regulators of G-protein signaling (RGS) 1 and 16 are induced in response to bacterial lipopolysaccharide and stimulate c-fos promoter expression
28. Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways
29. Transgenic Gαq overexpression induces cardiac contractile failure in mice
30. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes
31. Regulation of phospholipases C and D in rat ventricular myocytes: Stimulation by endothelin-1, bradykinin and phenylephrine
32. Alpha-1 adrenoceptor-mediated positive inotropic effect and inositol triphosphate increase in mammalian heart
33. Alterations in rat aortic alpha1-adrenergic stimulated phosphoinositide hydrolysis in intraperitoneal sepsis
34. In vivo and in vitro effects of endotoxin on vascular responsiveness to norepinephrine and signal transduction in the rat
35. Evidence for a short form of RGS3 preferentially expressed in the human heart
36. Tumor necrosis factor α decreases inositol phosphate formation and phosphatidylinositol-bisphosphate (PIP2) synthesis in rat cardiomyocytes