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Volumn 8, Issue 5, 1998, Pages 539-544

Muscle differentiation: More complexity to the network of myogenic regulators

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; MYOD PROTEIN; TRANSCRIPTION FACTOR;

EID: 0032191350     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(98)80008-7     Document Type: Article
Times cited : (250)

References (51)
  • 1
    • 0029876463 scopus 로고    scopus 로고
    • Targeted inactivation of myogenic factor genes reveals their roles during myogenesis: A review
    • Arnold HH, Braun T. Targeted inactivation of myogenic factor genes reveals their roles during myogenesis: a review. Int Dev Biol. 40:1996;345-363.
    • (1996) Int Dev Biol , vol.40 , pp. 345-363
    • Arnold, H.H.1    Braun, T.2
  • 2
    • 0030219748 scopus 로고    scopus 로고
    • Defining the regulatory networks for muscle development
    • Molkentin JD, Olson EN. Defining the regulatory networks for muscle development. Curr Opin Genet Dev. 6:1996;445-453.
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 445-453
    • Molkentin, J.D.1    Olson, E.N.2
  • 3
    • 0030560884 scopus 로고    scopus 로고
    • Skeletal muscle determination and differentiation: Story of a core regulatory network and its context
    • Yun KS, Wold BJ. Skeletal muscle determination and differentiation: story of a core regulatory network and its context. Curr Opin Cell Biol. 8:1996;877-889.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 877-889
    • Yun, K.S.1    Wold, B.J.2
  • 4
    • 0030022190 scopus 로고    scopus 로고
    • Activation of different myogenic pathways: Myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm
    • Cossu G, Kelly R, Tajbakhsh S, DiDonna S, Vivarelli E, Buckingham M. Activation of different myogenic pathways: Myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm. Development. 122:1996;429-437.
    • (1996) Development , vol.122 , pp. 429-437
    • Cossu, G.1    Kelly, R.2    Tajbakhsh, S.3    DiDonna, S.4    Vivarelli, E.5    Buckingham, M.6
  • 5
    • 0029950479 scopus 로고    scopus 로고
    • Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
    • Tajbakhsh S, Rocancourt D, Buckingham M. Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice. Nature. 384:1996;266-270.
    • (1996) Nature , vol.384 , pp. 266-270
    • Tajbakhsh, S.1    Rocancourt, D.2    Buckingham, M.3
  • 7
    • 0027297310 scopus 로고
    • Myogenin gene disruption results in perinatal lethality because of severe muscle defect
    • Nabeshima YK, Hanaoka K, Hayasaka M, Esumi S, Lis, Nonaka J. Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature. 364:1993;532-535.
    • (1993) Nature , vol.364 , pp. 532-535
    • Nabeshima, Y.K.1    Hanaoka, K.2    Hayasaka, M.3    Esumi, S.4    Lis5    Nonaka, J.6
  • 8
    • 0028906771 scopus 로고
    • Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development
    • Braun T, Arnold HH. Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development. EMBO J. 14:1995;1176-1186.
    • (1995) EMBO J , vol.14 , pp. 1176-1186
    • Braun, T.1    Arnold, H.H.2
  • 9
    • 0028844990 scopus 로고
    • Disruption of the MRF4 gene identifies multiple waves of myogenesis in the myotome
    • Patapoutian A, Yoon K, Miner H, Wang S, Stark K, Wold B. Disruption of the MRF4 gene identifies multiple waves of myogenesis in the myotome. Development. 12:1995;3347-3358.
    • (1995) Development , vol.12 , pp. 3347-3358
    • Patapoutian, A.1    Yoon, K.2    Miner, H.3    Wang, S.4    Stark, K.5    Wold, B.6
  • 10
    • 0029047267 scopus 로고
    • Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies
    • Zhang W, Behringer RR, Olson EN. Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 9:1995;1388-1399.
    • (1995) Genes Dev , vol.9 , pp. 1388-1399
    • Zhang, W.1    Behringer, R.R.2    Olson, E.N.3
  • 12
    • 0030025046 scopus 로고    scopus 로고
    • Functional redundancy of muscle-specific transcription factors Myf5 and myogenin
    • Wang Y, Schnegelsberg P, Dausman J, Jaenisch R. Functional redundancy of muscle-specific transcription factors Myf5 and myogenin. Nature. 379:1996;823-825.
    • (1996) Nature , vol.379 , pp. 823-825
    • Wang, Y.1    Schnegelsberg, P.2    Dausman, J.3    Jaenisch, R.4
  • 13
    • 0030758661 scopus 로고    scopus 로고
    • Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently
    • of special interest. The first knock-in experiment replacing one myogenic bHLH factor gene by another addresses the issue of unique intrinsic properties of Myf-5 and myogenin versus functional differences as a result of their distinct expression patterns. The results reveal that myogenin expressed under the control of the Myf-5 gene can partially substitute for Myf-5 but is unable to compensate for loss of a second myogenic bHLH gene in double mutants also lacking either MyoD or myogenin. This suggests that myogenin only inefficiently compensates for Myf-5, probably owing to altered levels of gene expression and/or different transactivation properties.
    • Wang Y, Jaenisch R. Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently. of special interest Development. 124:1997;2510-2513 The first knock-in experiment replacing one myogenic bHLH factor gene by another addresses the issue of unique intrinsic properties of Myf-5 and myogenin versus functional differences as a result of their distinct expression patterns. The results reveal that myogenin expressed under the control of the Myf-5 gene can partially substitute for Myf-5 but is unable to compensate for loss of a second myogenic bHLH gene in double mutants also lacking either MyoD or myogenin. This suggests that myogenin only inefficiently compensates for Myf-5, probably owing to altered levels of gene expression and/or different transactivation properties.
    • (1997) Development , vol.124 , pp. 2510-2513
    • Wang, Y.1    Jaenisch, R.2
  • 14
    • 0031034468 scopus 로고    scopus 로고
    • Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: A mechanism for lineage determination in myogenesis
    • of special interest. This study provides evidence that MyoD and Myf-5 can remodel chromatin at binding sites in muscle gene enhancers and activate transcription at previously silent loci, whereas myogenin is markedly less efficient at activating genes in transcriptionally silent chromatin. The ability of MyoD to activate endogenous genes is associated with two regions in the protein that are distinct from its transactivation domain and are conserved in the Myf-5 protein, TGF-β, basic FGF, and sodium butyrate - known inhibitors of myogenesis - block MyoD-mediated chromatin reorganization. These results may provide a molecular basis for the fact that MyoD and Myf-5 establish the myogenic lineage, whereas myogenin mediates terminal differentiation.
    • Gerber AN, Klesert TR, Bergstrom DA, Tapscott SJ. Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis. of special interest Genes Dev. 11:1997;436-450 This study provides evidence that MyoD and Myf-5 can remodel chromatin at binding sites in muscle gene enhancers and activate transcription at previously silent loci, whereas myogenin is markedly less efficient at activating genes in transcriptionally silent chromatin. The ability of MyoD to activate endogenous genes is associated with two regions in the protein that are distinct from its transactivation domain and are conserved in the Myf-5 protein, TGF-β, basic FGF, and sodium butyrate - known inhibitors of myogenesis - block MyoD-mediated chromatin reorganization. These results may provide a molecular basis for the fact that MyoD and Myf-5 establish the myogenic lineage, whereas myogenin mediates terminal differentiation.
    • (1997) Genes Dev , vol.11 , pp. 436-450
    • Gerber, A.N.1    Klesert, T.R.2    Bergstrom, D.A.3    Tapscott, S.J.4
  • 15
    • 0030945778 scopus 로고    scopus 로고
    • MRF4 can substitute for myogenin during early stages of myogenesis
    • Zhu Z, Miller JB. MRF4 can substitute for myogenin during early stages of myogenesis. Dev Dyn. 209:1997;233-241.
    • (1997) Dev Dyn , vol.209 , pp. 233-241
    • Zhu, Z.1    Miller, J.B.2
  • 16
    • 0031927208 scopus 로고    scopus 로고
    • Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice
    • of special interest. Circumstantial evidence had suggested that MRF4 may fulfil late functions in muscle differentiation, similar to and possibly overlapping with myogenin. Double mutant mice for MRF4 and myogenin now show that neither gene is absolutely essential for myoblast differentiation; instead, any of the four myogenic bHLH factors appears capable of activating the muscle differentiation program under the appropriate conditions. Unexpectedly, MRF4/MyoD double mutants reveal overlapping roles of both genes in the control of myoblast differentiation, as the mutants lack differentiated myotubes. As Myf-5 and myogenin are expressed in these mutants, the observations suggest that critical threshold concentrations of myogenic bHLH factors may be needed for myoblast differentiation to occur.
    • Rawls A, Valdez MR, Zhang W, Richardson J, Klein WH, Olson EN. Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. of special interest Development. 125:1998;2349-2358 Circumstantial evidence had suggested that MRF4 may fulfil late functions in muscle differentiation, similar to and possibly overlapping with myogenin. Double mutant mice for MRF4 and myogenin now show that neither gene is absolutely essential for myoblast differentiation; instead, any of the four myogenic bHLH factors appears capable of activating the muscle differentiation program under the appropriate conditions. Unexpectedly, MRF4/MyoD double mutants reveal overlapping roles of both genes in the control of myoblast differentiation, as the mutants lack differentiated myotubes. As Myf-5 and myogenin are expressed in these mutants, the observations suggest that critical threshold concentrations of myogenic bHLH factors may be needed for myoblast differentiation to occur.
    • (1998) Development , vol.125 , pp. 2349-2358
    • Rawls, A.1    Valdez, M.R.2    Zhang, W.3    Richardson, J.4    Klein, W.H.5    Olson, E.N.6
  • 17
    • 0028875718 scopus 로고
    • Combinatorial signaling by sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in somites
    • Münsterberg AE, Kitajewski J, Bumcrot DA, McMahon AP, Lassar AB. Combinatorial signaling by sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in somites. Genes Dev. 9:1995;2911-2922.
    • (1995) Genes Dev , vol.9 , pp. 2911-2922
    • Münsterberg, A.E.1    Kitajewski, J.2    Bumcrot, D.A.3    McMahon, A.P.4    Lassar, A.B.5
  • 18
    • 0028826466 scopus 로고
    • Myogenesis in paraxial mesoderm: Preferential induction by dorsal neural tube and by cells expressing Wnt-1
    • Stern HM, Brown AMC, Hauschka SD. Myogenesis in paraxial mesoderm: Preferential induction by dorsal neural tube and by cells expressing Wnt-1. Development. 121:1995;3675-3686.
    • (1995) Development , vol.121 , pp. 3675-3686
    • Stern, H.M.1    Brown, A.M.C.2    Hauschka, S.D.3
  • 19
    • 0030030316 scopus 로고    scopus 로고
    • The dorsal neural tube organizes the dermamyotome and induces axial myocytes in the avian embryo
    • Spence MS, Yip J, Erickson CA. The dorsal neural tube organizes the dermamyotome and induces axial myocytes in the avian embryo. Development. 122:1996;231-241.
    • (1996) Development , vol.122 , pp. 231-241
    • Spence, M.S.1    Yip, J.2    Erickson, C.A.3
  • 20
    • 0032005789 scopus 로고    scopus 로고
    • Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression
    • Reshef R, Maroto M, Lassar AB. Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. Genes Dev. 12:1998;290-303.
    • (1998) Genes Dev , vol.12 , pp. 290-303
    • Reshef, R.1    Maroto, M.2    Lassar, A.B.3
  • 21
    • 0027226234 scopus 로고
    • Separable regulatory elements governing myogenin transcription in mouse embryogenesis
    • Cheng TC, Wallace MC, Merlie JP, Olson EN. Separable regulatory elements governing myogenin transcription in mouse embryogenesis. Science. 261:1993;215-218.
    • (1993) Science , vol.261 , pp. 215-218
    • Cheng, T.C.1    Wallace, M.C.2    Merlie, J.P.3    Olson, E.N.4
  • 22
    • 0027227469 scopus 로고
    • The regulation of myogenin gene expression during the embryonic development of the mouse
    • Yee SP, Rigby PW. The regulation of myogenin gene expression during the embryonic development of the mouse. Genes Dev. 7:1993;1277-1289.
    • (1993) Genes Dev , vol.7 , pp. 1277-1289
    • Yee, S.P.1    Rigby, P.W.2
  • 23
    • 0028287953 scopus 로고
    • The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF2
    • Buchberger A, Ragge K, Arnold HH. The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF2. J Biol Chem. 286:1994;17289-17296.
    • (1994) J Biol Chem , vol.286 , pp. 17289-17296
    • Buchberger, A.1    Ragge, K.2    Arnold, H.H.3
  • 24
    • 0028900130 scopus 로고
    • Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis
    • Naidu PS, Ludolph DC, To RR, Hinterberger TJ, Konieczny SF. Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. Mol Cell Biol. 15:1995;2707-2718.
    • (1995) Mol Cell Biol , vol.15 , pp. 2707-2718
    • Naidu, P.S.1    Ludolph, D.C.2    To, R.R.3    Hinterberger, T.J.4    Konieczny, S.F.5
  • 25
    • 0028796735 scopus 로고
    • The mouse MRF4 promoter is transactivated directly and indirectly by muscle-specific transcription factors
    • Black BL, Martin JF, Olson EN. The mouse MRF4 promoter is transactivated directly and indirectly by muscle-specific transcription factors. J Biol Chem. 270:1995;2889-2892.
    • (1995) J Biol Chem , vol.270 , pp. 2889-2892
    • Black, B.L.1    Martin, J.F.2    Olson, E.N.3
  • 26
    • 0031052267 scopus 로고    scopus 로고
    • Distal regulatory elements control MRF4 gene expression in early and late myogenic cell populations
    • Pin CL, Ludolph DC, Cooper ST, Klocke BJ, Merlie JP, Konieczny SF. Distal regulatory elements control MRF4 gene expression in early and late myogenic cell populations. Dev Dyn. 208:1997;299-312.
    • (1997) Dev Dyn , vol.208 , pp. 299-312
    • Pin, C.L.1    Ludolph, D.C.2    Cooper, S.T.3    Klocke, B.J.4    Merlie, J.P.5    Konieczny, S.F.6
  • 27
    • 0027253994 scopus 로고
    • Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice
    • Patapoutian A, Miner H, Lyons GE, Wold B. Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice. Development. 118:1993;61-69.
    • (1993) Development , vol.118 , pp. 61-69
    • Patapoutian, A.1    Miner, H.2    Lyons, G.E.3    Wold, B.4
  • 28
    • 0031444097 scopus 로고    scopus 로고
    • Faithful expression of the Myf-5 gene during mouse myogenesis requires distant control regions: A transgene approach using yeast artificial chromosomes
    • Zweigerdt R, Braun T, Arnold HH. Faithful expression of the Myf-5 gene during mouse myogenesis requires distant control regions: a transgene approach using yeast artificial chromosomes. Dev Biol. 191:1997;172-180.
    • (1997) Dev Biol , vol.191 , pp. 172-180
    • Zweigerdt, R.1    Braun, T.2    Arnold, H.H.3
  • 29
    • 0029915990 scopus 로고    scopus 로고
    • Pax 3 is necessary for migration but not differentiation of limb muscle precursors in the mouse
    • Daston G, Lamar E, Olivier M, Goulding M. Pax 3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 122:1996;1017-1027.
    • (1996) Development , vol.122 , pp. 1017-1027
    • Daston, G.1    Lamar, E.2    Olivier, M.3    Goulding, M.4
  • 30
    • 0028205002 scopus 로고
    • Pax 3 is required for the development of limb muscles: A possible role for the migration of dermomyotomal muscle progenitor cells
    • Bober E, Franz T, Arnold HH, Gruss P, Trambley P. Pax 3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development. 120:1994;603-612.
    • (1994) Development , vol.120 , pp. 603-612
    • Bober, E.1    Franz, T.2    Arnold, H.H.3    Gruss, P.4    Trambley, P.5
  • 31
    • 0030891169 scopus 로고    scopus 로고
    • Redefining the genetic hierarchies controlling skeletal myogeneis: Pax 3 and myf5 act upstream of myoD
    • of outstanding interest. This paper establishes Pax3 as a key regulator in skeletal muscle development. By a genetic approach, the authors demonstrate that MyoD gene activation in body muscle precursors is dependent on either Pax3 or Myf-5. In Pax3/Myf-5 double homozygous mutant mice, MyoD is not expressed and body muscles are completely absent. Thus, Pax3 and Myf-5 define two distinct myogenic pathways and both genes act genetically upstream of MyoD. This hierarchy, however, does not apply to head muscle formation.
    • Tajbakhsh S, Rocancourt D, Cossu G, Buckingham M. Redefining the genetic hierarchies controlling skeletal myogeneis: pax 3 and myf5 act upstream of myoD. of outstanding interest Cell. 89:1997;127-138 This paper establishes Pax3 as a key regulator in skeletal muscle development. By a genetic approach, the authors demonstrate that MyoD gene activation in body muscle precursors is dependent on either Pax3 or Myf-5. In Pax3/Myf-5 double homozygous mutant mice, MyoD is not expressed and body muscles are completely absent. Thus, Pax3 and Myf-5 define two distinct myogenic pathways and both genes act genetically upstream of MyoD. This hierarchy, however, does not apply to head muscle formation.
    • (1997) Cell , vol.89 , pp. 127-138
    • Tajbakhsh, S.1    Rocancourt, D.2    Cossu, G.3    Buckingham, M.4
  • 32
    • 0030891318 scopus 로고    scopus 로고
    • Ectopic pax3 activates myoD and myf5 expression in embryonic mesoderm and neural tissue
    • of outstanding interest. The study demonstrates that signals from ectoderm or Wnt and Sonic hedgehog can induce dermomyotomal and myotomal markers in presegmented mesoderm. Pax3 and Pax7 are induced concomitantly with Myf-5 and prior to MyoD. Moreover, retroviral expression of Pax3 in embryonic tissues, such as paraxial and lateral plate mesoderm as well as neural tube explants induces MyoD expression and myogenesis in the absence of inducing signals. These results imply that Pax3 mediates activation of Myf-5 and MyoD expression in response to muscle-inducing signals.
    • Maroto M, Reshef R, Münsterberg AE, Koester S, Goulding M, Lassar AB. Ectopic pax3 activates myoD and myf5 expression in embryonic mesoderm and neural tissue. of outstanding interest Cell. 89:1997;139-148 The study demonstrates that signals from ectoderm or Wnt and Sonic hedgehog can induce dermomyotomal and myotomal markers in presegmented mesoderm. Pax3 and Pax7 are induced concomitantly with Myf-5 and prior to MyoD. Moreover, retroviral expression of Pax3 in embryonic tissues, such as paraxial and lateral plate mesoderm as well as neural tube explants induces MyoD expression and myogenesis in the absence of inducing signals. These results imply that Pax3 mediates activation of Myf-5 and MyoD expression in response to muscle-inducing signals.
    • (1997) Cell , vol.89 , pp. 139-148
    • Maroto, M.1    Reshef, R.2    Münsterberg, A.E.3    Koester, S.4    Goulding, M.5    Lassar, A.B.6
  • 33
    • 0010300155 scopus 로고    scopus 로고
    • Mice lacking paraxis and Myf-5 display severe defects in skeletal muscle and axial skeleton
    • Rawls JA, Parsons S, Wilson-Rawls NJ. Mice lacking paraxis and Myf-5 display severe defects in skeletal muscle and axial skeleton. Dev Biol. 198:1998;217.
    • (1998) Dev Biol , vol.198 , pp. 217
    • Rawls, J.A.1    Parsons, S.2    Wilson-Rawls, N.J.3
  • 34
    • 0028808913 scopus 로고
    • Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors
    • Olson EN, Perry M, Schulz RA. Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors. Dev Biol. 172:1995;2-14.
    • (1995) Dev Biol , vol.172 , pp. 2-14
    • Olson, E.N.1    Perry, M.2    Schulz, R.A.3
  • 36
    • 0028917564 scopus 로고
    • Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
    • Lilly B, Zhao B, Ranganayakulu G, Paterson BM, Schulz RA, Olson EN. Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science. 267:1995;688-693.
    • (1995) Science , vol.267 , pp. 688-693
    • Lilly, B.1    Zhao, B.2    Ranganayakulu, G.3    Paterson, B.M.4    Schulz, R.A.5    Olson, E.N.6
  • 37
    • 0028841777 scopus 로고
    • A series of mutations in the D-MEF2 transcription factor reveals multiple functions in larval and adult myogenesis in Drosophila
    • Ranganayakulu G, Zhao B, Dokodis A, Molkentin JD, Olson EN, Schulz RA. A series of mutations in the D-MEF2 transcription factor reveals multiple functions in larval and adult myogenesis in Drosophila. Dev Biol. 171:1995;169-181.
    • (1995) Dev Biol , vol.171 , pp. 169-181
    • Ranganayakulu, G.1    Zhao, B.2    Dokodis, A.3    Molkentin, J.D.4    Olson, E.N.5    Schulz, R.A.6
  • 38
    • 0030911475 scopus 로고    scopus 로고
    • Control of mouse cardiac morphogenesis and myogenesis by the myogenic transcription factor MEF2C
    • Lin Q, Schwarz JJ, Bucana C, Olson EN. Control of mouse cardiac morphogenesis and myogenesis by the myogenic transcription factor MEF2C. Science. 278:1997;1404-1407.
    • (1997) Science , vol.278 , pp. 1404-1407
    • Lin, Q.1    Schwarz, J.J.2    Bucana, C.3    Olson, E.N.4
  • 39
    • 0029590104 scopus 로고
    • Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
    • Molkentin JD, Black BL, Martin JF, Olson EN. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell. 83:1995;1125-1136.
    • (1995) Cell , vol.83 , pp. 1125-1136
    • Molkentin, J.D.1    Black, B.L.2    Martin, J.F.3    Olson, E.N.4
  • 40
    • 0031972698 scopus 로고    scopus 로고
    • Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2
    • note
    • Black BL, Molkentin JD, Olson EN. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. of special interest Mol Cell Biol. 18:1998;69-77 Synergistic activation of muscle-specific transcription by myogenic bHLH and MEF2 transcription factors occurs through interaction between these proteins and binding of the complex to either bHLH or MEF2 DNA target sites. The ability of these proteins to synergistically initiate myogenesis is dependent on two conserved animo acid residues: alanine and threonine in the basic domain of the myogenic bHLH factors. The paper now demonstrates that these two 'myogenic' amino acids are not required to form complexes between bHLH proteins and MEF2 factors but to acquire the transactivation competence provided either from the MyoD or MEF2 transactivation domain. Thus, MEF2 may be the putative myogenic cofactor which allows transmission of transcriptional activation signals, possibly by inducing a compatible conformation for interaction with the basal transcription machinery or other cofactors. The dependence on the basic domain of MyoD (alanine and threonine) can be bypassed by substitution of the MyoD or the MEF2 activation domain with the activation domain of VP16. As myogenic bHLH-MEF2 interactions can be uncoupled from transcriptional activation, the results support the idea that the myogenic amino acids in myogenic bHLH proteins are essential for generating the transactivation capacity.
    • (1998) Mol Cell Biol , vol.18 , pp. 69-77
    • Black, B.L.1    Molkentin, J.D.2    Olson, E.N.3
  • 41
    • 0031045835 scopus 로고    scopus 로고
    • Molecular mechanisms of myogenic coactivation by p300: Direct interaction with the activation domain of MyoD and with the MADS box of MEF2C
    • Sartorelli V, Huang J, Hamamori Y, Kedes L. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol. 17:1997;1010-1026.
    • (1997) Mol Cell Biol , vol.17 , pp. 1010-1026
    • Sartorelli, V.1    Huang, J.2    Hamamori, Y.3    Kedes, L.4
  • 42
    • 0028073676 scopus 로고
    • Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation
    • Arber S, Halder G, Caroni P. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Cell. 79:1994;221-231.
    • (1994) Cell , vol.79 , pp. 221-231
    • Arber, S.1    Halder, G.2    Caroni, P.3
  • 43
    • 0030753648 scopus 로고    scopus 로고
    • Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD
    • Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 17:1997;4750-4760.
    • (1997) Mol Cell Biol , vol.17 , pp. 4750-4760
    • Kong, Y.1    Flick, M.J.2    Kudla, A.J.3    Konieczny, S.F.4
  • 44
    • 0030862345 scopus 로고    scopus 로고
    • Synergistic interactions between bFGF and a TGF-beta family member may mediate myogenic signals from the neural tube
    • Stern HM, Lin-Jones J, Hauschka SD. Synergistic interactions between bFGF and a TGF-beta family member may mediate myogenic signals from the neural tube. Development. 124:1997;3511-3523.
    • (1997) Development , vol.124 , pp. 3511-3523
    • Stern, H.M.1    Lin-Jones, J.2    Hauschka, S.D.3
  • 45
    • 0031010050 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member
    • McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature. 387:1997;83-90.
    • (1997) Nature , vol.387 , pp. 83-90
    • McPherron, A.C.1    Lawler, A.M.2    Lee, S.J.3
  • 46
    • 0030754089 scopus 로고    scopus 로고
    • Differential interactions of Id proteins with basic-helix-loop-helix transcription factors
    • Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J Biol Chem. 272:1997;19785-19793.
    • (1997) J Biol Chem , vol.272 , pp. 19785-19793
    • Langlands, K.1    Yin, X.2    Anand, G.3    Prochownik, E.V.4
  • 47
    • 0029890899 scopus 로고    scopus 로고
    • Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist
    • Spicer DB, Rhee SJ, Cheung WL, Lassar AB. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science. 272:1996;1476-1480.
    • (1996) Science , vol.272 , pp. 1476-1480
    • Spicer, D.B.1    Rhee, S.J.2    Cheung, W.L.3    Lassar, A.B.4
  • 48
    • 0030881743 scopus 로고    scopus 로고
    • The basic domain of myogenic bHLH proteins is the novel target for direct inhibition by another bHLH protein, Twist
    • Hamamori Y, Wu HY, Sartorelli V, Kedes L. The basic domain of myogenic bHLH proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol. 17:1997;6563-6573.
    • (1997) Mol Cell Biol , vol.17 , pp. 6563-6573
    • Hamamori, Y.1    Wu, H.Y.2    Sartorelli, V.3    Kedes, L.4
  • 49
    • 0032473502 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD
    • Lemercier C, To RQ, Carrasco RA, Konieczny SF. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD. EMBO J. 17:1998;1412-1422.
    • (1998) EMBO J , vol.17 , pp. 1412-1422
    • Lemercier, C.1    To, R.Q.2    Carrasco, R.A.3    Konieczny, S.F.4
  • 50
    • 0030572709 scopus 로고    scopus 로고
    • I-mf, a novel myogenic repressor interacts with members of the MyoD family
    • Chen CM, Kraut N, Groudine M, Weintraub H. I-mf, a novel myogenic repressor interacts with members of the MyoD family. Cell. 86:1996;731-741.
    • (1996) Cell , vol.86 , pp. 731-741
    • Chen, C.M.1    Kraut, N.2    Groudine, M.3    Weintraub, H.4
  • 51
    • 0030960196 scopus 로고    scopus 로고
    • ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation
    • Postigo AA, Dean DC. ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation. EMBO J. 16:1997;3935-3943.
    • (1997) EMBO J , vol.16 , pp. 3935-3943
    • Postigo, A.A.1    Dean, D.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.