IL-10 gene transfer to intracranial 9L glioma: Tumor inhibition and cooperation with IL-2

Journal of Neuroimmunology

Volumn 92, Issue 1-2, 1998, Pages 50-59

  Book, Adam A ^a,b   Fielding, Kevin E ^b   Kundu, Namita ^c   Wilson, Mary Ann ^a,b   Fulton, Amy M ^c   Laterra, John ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Anti tumor immunity; Cytokine; Gene therapy; Neuroimmunology

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE TARGETING; GENE TRANSFER; GLIOMA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR IMMUNITY;

ANIMALS; ANTIBODY FORMATION; BRAIN NEOPLASMS; DRUG SYNERGISM; GENE TRANSFER TECHNIQUES; GLIOMA; INTERLEUKIN-10; INTERLEUKIN-2; MICE; RATS; TUMOR CELLS, CULTURED;

EID: 0032446571     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00172-6     Document Type: Article

References (47)

1. Neuro-oncology, 1990. Primary malignant brain tumours. In: Thomas, D.G.T. (Ed.), Neuro-oncology. Primary Malignant Brain Tumours, Johns Hopkins Univ. Press, Baltimore, MD.
2. Arosarena O., Guerin C., Brem H., Laterra J. Endothelial differentiation in intracerebral and subcutaneous experimental gliomas. Brain Res. 640:1994;98-104.
3. Berman R.M., Suzuki T., Tahara H., Robbins P.D., Narula S.K., Lotze M.T. Systemic administration of cellular IL-10 induces an effective, specific and long-lived immune response against established tumors in mice. J. Immunol. 157:1996;231-238.
4. Blazar B., Taylor P.A., Smith S., Vallera D.A. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts. Blood. 85:1995;842.
5. Brem S., Cotran R., Folkman J. Tumor angiogenesis: a quantitative method for histologic grading. J. Natl. Cancer Inst. 48:1972;347-356.
6. Burger P.C., Vogel F.S., Green S.B., Strike T.A. Glioblastoma multiforme and anaplastic astrocytoma. Cancer. 56:1985;1106-1111.
7. Carson W.E., Lindemann M.J., Baiocchi R., Linett M., Tan J.C., Chou C.-C., Narula S., Caligiuri M.A. The functional characterization of interleukin-10 receptor expression on human natural killer cells. Blood. 85:1995;3577-3585.
8. Chen W.-F., Zlotnik IL-10: a novel cytotoxic T cell differentiation factor. J. Immunol. 147:1991;528-534.
9. Chernoff A.E., Granowitz E.V., Shapiro L., Vannier E., Lonnemann G., Angel J.B., Kennedy J.S., Rabson A.R., Wolff S.M., Dinarello C.A. A randomized, controlled trial of IL-10 in humans. J. Immunol. 154:1995;5492-5499.
10. Fakhrai H., Dorigo O., Shawler D.L., Lin H., Mercola D., Black K.L., Royston I., Sobol R.E. Eradication of established intracranial rat gliomas by transforming growth factor β antisense gene therapy. Proc. Natl. Acad. Sci. U.S.A. 93:1996;2909-2914.
11. Fiorentino D.F., Bond M.W., Mosmann T.R. Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:1989;2081-2095.
12. Fluckiger A.-C., Garrone P., Durand I., Galizzi J.-P., Branchereau J. Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J. Exp. Med. 178:1993;1473-1481.
13. Fujita S., Puri R.K., Yu Z.-X., Travis W.D., Ferrans V.J. An ultrastructural study of in vivo interactions between lymphocytes and endothelial cells in the pathogenesis of the vascular leak syndrome induced by interleukin-2. Cancer. 68:1991;2169-2174.
14. Gansbacher B., Zier K., Daniels B., Cronin K., Bannerji R., Gilboa E. Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J. Exp. Med. 172:1990;1217-1224.
15. Giovarelli M., Musiani P., Modesti A., Dellabona P., Casorati G., Allione A., Consalvo M., Cavallo F., di Pierro F., De Giovanni C., Musso T., Forni G. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J. Immunol. 155:1995;3112-3123.
16. Glick R.P., Lichtor T., Kim T.S., Ilangovan S., Cohen E.P. Fibroblasts genetically engineered to secrete cytokines suppress tumor growth and induce antitumor immunity to a murine glioma in vivo. Neurosurgery. 36:1995;548-555.
17. + T cells. J. Immunol. 160:1998;3188-3193.
18. Hagenbaugh A., Sharma S., Dubinett S.M., Wei S.H.Y., Aranda R., Cheroutre H., Fowell D.J., Binder S., Tsao B., Lockszley R.M., Moore K.W., Kronenberg M. Altered immune responses in interleukin 10 transgenic mice. J. Exp. Med. 185:1997;2101-2110.
19. Hanisch U.-K., Neuhaus J., Quirion R., Kettenmann H. Neurotoxicity induced by interleukin-2: involvement of infiltrating immune cells. Synapse. 24:1996;104-114.
20. Heaton K.M., Grimm E.A. Cytokine combinations in immunotherapy for solid tumors: a review. Cancer Immunol. Immunother. 37:1993;213-219.
21. Hishii M., Nitta T., Ishida H., Ebato M., Kurosu A., Yagita H., Sato K., Okumura K. Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro. Neurosurgery. 37:1995;1160-1166.
22. Hsu S.M., Raine L., Fanger H. The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29:1981;577-580.
23. Huang S., Zie K., Bucana C.D., Ulrich S.E., Bar-Eli M. Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis. Clin. Cancer Res. 2:1997;1969-1979.
24. Huettner C., Paulus W., Roggendoorf W. Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas. Am. J. Pathol. 146:1995;317-322.
25. Huhn R.D., Radwanski E., O'Connell S.M., Sturgill M.G., Clarke L., Cody R.P., Affrime M.B., Cutler D.L. Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers. Blood. 87:1996;699-705.
26. Itoh K., Inoue T., Ito K., Hirohata S. The interplay of interleukin-10 (IL-10) and interleukin-2 (IL-2) in humoral immune responses: IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression. Cellular Immunology. 157:1994;478-488.
27. Karasuyama H., Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:1988;97-104.
28. Kundu N., Fulton A.M. Interleukin 10 inhibits tumor metastasis, downregulates MHC class I and enhances NK lysis. Cell Immunol. 180:1997;55-61.
29. Kundu N., Beaty T.L., Hackson M.J., Fulton A.M. Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer. J. Natl. Cancer Inst. 88:1996;536-541.
30. Lal B., Indurti R.R., Couraud P.-O., Goldstein G.W., Laterra J. Endothelial cell implantation and survival within experimental gliomas. Proc. Natl. Acad Sci. U.S.A. 91:1994;9695-9699.
31. Levraud J.-P., Duffour M.-T., Cordier L., Perricaudet M., Haddada H., Kourilsky P. IL-2 gene delivery within an established murine tumor causes its regression without proliferation of preexisting antitumor-specific CTL. J. Immunol. 158:1997;3335-3343.
32. De Waal-Malefyt R., Abrams J., Bennett B., Figdor C.G., de Vries J.E. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1991;1209-1220.
33. Nam M., Johnston P., Lal B., Indurti R., Wilson M.A., Laterra J. Endothelial cell-based anti-tumor gene delivery to brain. Brain Res. 731:1996;161-170.
34. Powrie F., Menon S., Coffman R.L. Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 23:1993;3043-3049.
35. Richter G., Kruger-Krasagakes S., Hein G., Huls C., Schmitt E., Diamantstein T., Blankenstein T. Interleukin 10 transfected into chinese hamster ovary cells prevents tumor growth and macrophage infiltration. Cancer Res. 53:1993;4134-4137.
36. Robinson A.P., Puklavec M., Mason D.W. MRC OX-52: a rat T-cell antigen. Immunology. 57:1986;527-531.
37. Roth C., Mir L.M., Cressent M., Quintin-Colonna F., Ley V., Fradelizi D., Kourilsky P. Inhibition of tumor growth by histoincompatible cells expressing interleukin-2. Intl. Immunol. 4:1992;1429-1436.
38. Roux F., Durieu-Trautmann O., Chaverot N., Claire M., Mailly P., Bourre J.M., Strosberg A.D., Couraud P.-O. Regulation of γ-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J. Cell Physiol. 159:1994;101-113.
39. Schmidek H., Nielsen S., Schiller A., Messer J. Morphological studies of rat brain tumors induced by N-nitrosomethylurea. J. Neurosurg. 34:1971;335-340.
40. Schwarz M.A., Hamilton L.D., Tardelli L., Narula S.K., Sullivan L.M. Stimulation of cytolytic activity by interleukin-10. J. Immunother. 16:1994;95-104.
41. Taga K., Cherney B., Tosato G. IL-10 inhibits apoptotic cell death in human T cell starved of IL-2. Intl. Immunol. 5:1993;1599.
42. Tamargo R., Leong K., Brem H. Growth Inhibition of the 9L glioma using polymers to release heparin and cortisone acetate. J. Neuro-Oncol. 9:1990;131-138.
43. Tjuvajev J., Gansbacher B., Desai R., Beattie B., Kaplitt M., Matei C., Koutcher J., Gilboa E., Blasberg R. RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-γ Cancer Res. 55:1995;1902-1910.
44. Trojan J., Johnson T.R., Rudin S.D., Ilan J., Tykocinski M.L., Ilan J. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science. 259:1993;94-97.
45. Vieira P., De Waal-Malefyt R., Dang M.-N., Johnson K.E., Kastelein R., Fiorentino D.F., DeVries J.E., Roncarolo M.-G., Mosmann T.R., Moore K.W. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frameBCRFI. Proc. Natl. Acad Sci. U.S.A. 88:1991;1172-1176.
46. Yu J.S., Wei M.X., Chiocca E.A., Martuza R.L., Tepper R.I. Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res. 53:1993;3125-3128.
47. Zheng L.M., Ojcius D.M., Garaud F., Roth C., Maxwell E., Li Z., Rong H., Chen J., Wang X.Y., Catino J.J., King I. Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism. J. Exp. Med. 184:1996;579-584.