Inhibition of interleukin-10 (IL-10) production from MOPC 315 tumor cells by IL-10 antisense oligodeoxynucleotides enhances cell-mediated immune responses

Cancer Immunology Immunotherapy

Volumn 49, Issue 8, 2000, Pages 433-440

  Kim, Byung Gyu ^a   Joo, Hong Gu ^a   Chung, In Sung ^a   Chung, Hee Yong ^a   Woo, Hee Jong ^b   Yun, Yeon Sook ^a  

^a Korea Cancer Center Hospital   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Antisense oligodeoxynucleotide; B7 1; IL 10; MHC; Tumor immunity

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; B7 ANTIGEN; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CANCER GRAFT; CARCINOGENICITY; CELL TYPE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FEMALE; HOST CELL; IMMUNE SYSTEM; IMMUNOGENICITY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

EID: 0033803523     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620000123     Document Type: Article

References (36)

1. 2
2. Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-14, IL-6, IL-7, IL-10, tumor necrosis factor α, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants
3. IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells
4. Costimulation of T cells for tumor immunity
5. Production of 1L-10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma
6. IL-10: A novel cytotoxic T cell differentiation factor
7. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
8. Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
9. IL-10 inhibits cytokine production by activated macrophages
10. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
11. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
12. Loss of tumorigenicity and increased immunogenicity induced by interleukin-10 gene transfer in B16 melanoma cells
13. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
14. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory
15. Importance of TNF production for the curative effectiveness of low dose melphalan therapy for mice bearing a large MOPC-315 tumor
16. Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site
17. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
18. Human non-small cell lung cancer cells express a type 2 cytokine pattern
19. Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas
20. + T lymphocyte migration
21. IL-10 production in cutaneous basal and squamous cell carcinoma. A mechanism for evading the local T cell immune response
22. Anti-metastatic and antitumor activities of interleukin-10 in a murine model of breast cancer
23. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
24. The role of the CD28 receptor during T cell responses to antigen
25. IL-10, a novel growth cofactor for mature and immature T cells
26. Host immune response in renal cell cancer: Interleukin-4 (IL-4) and IL-10 mRNA are frequently detected in freshly collected tumor-infiltrating lymphocytes
27. Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma
28. Immunosuppressive cytokines (IL-10, TGF-β) genes expression in human gastric carcinoma tissues
29. Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression
30. Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1
31. IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression
32. Stimulation of cytolytic activity by interleukin 10
33. + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection
34. Interleukin 10: A novel stimulatory factor for mast cells and their progenitors
35. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
36. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression