Expression of the chemokines IP-10 and Mig in IL-10 transduced tumors

Journal of Immunotherapy

Volumn 24, Issue 2, 2001, Pages 138-143

  Sun, H ^a   Kundu, N ^a   Dorsey, R ^a   Jackson, M J ^a   Fulton, A M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Chemokines; Cytokines; Tumor immunity

Indexed keywords

CHEMOKINE; CHEMOKINE ERG2; CHEMOKINE MIG; INDUCIBLE PROTEIN 10; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 10; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL CLONE; CELL INFILTRATION; CELL TRANSPLANTATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANIMALS; BLOTTING, NORTHERN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINES, CXC; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON TYPE II; INTERLEUKIN-10; KINETICS; LIPOPOLYSACCHARIDES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MONOKINES; NEOPLASM TRANSPLANTATION; RNA, MESSENGER; RNA, NEOPLASM; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035126948     PISSN: 10538550     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002371-200103000-00008     Document Type: Article

References (22)

1. Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration
2. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory
3. Interleukin 10 inhibits tumor metastasis through an NK cell dependent mechanism
4. Systemic administration of cellular IL-10 induces an effective, specific and long-lived immune response against established tumors in mice
5. Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer
6. Interleukin 10 inhibits tumor metastasis, downregulates MHC class I and enhances NK lysis
7. Interferon inducible protein 10 identified as a mediator of tumor necrosis in vivo
8. Mig, the monokine induced by interferon-γ, promotes tumor necrosis in vivo
9. The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor
10. A macrophage mRNA selectively induced by γ-interferon encodes a member of the platelet factor 4 family of cytokines
11. Mig and IP-10: CXC chemokines that target lymphocytes
12. Interleukin 10 gene transfer activates interferon-γ and the interferon-γ-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors
13. Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-γ with patterns of tissue expression that suggest nonredundant roles in vivo
14. The T cell-specific CXC chemokines IP-10, Mig and I-TAC are expressed by activated human bronchial epithelial cells
15. Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxide
16. Essential role of nitric oxide and interferon-γ for tumor immunotherapy with interleukin-10
17. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis
18. Biochemical characterization of a γ-interferon-inducible cytokine (IP- 10)
19. Regulated production of the interferon-γ-inducible protein-10 (IP-10) chemokine by human neutrophils
20. Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma
21. Tumor angiogenesis is regulated by CXC chemokines
22. Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: Potential inhibition of angiogenesis