Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen

International Journal of Cancer

Volumn 97, Issue 1, 2002, Pages 58-63

  Huarte, Eduardo ^a   Sarobe, Pablo ^a   Lasarte, Juan José ^a   Brem, Gottfried ^b   Weiss, Elisabeth H ^c   Prieto, Jesús ^a   Borrás Cuesta, Francisco ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c Institut fur Anthropologie und Humangenetik   (Germany)

Author keywords

Carcinoembryonic antigen; Cytotoxic T lymphocyte; HLA B27; Peptides; Tumor

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CD8 ANTIGEN; EPITOPE; HLA B27 ANTIGEN; PEPTIDE DERIVATIVE; SYNTHETIC PEPTIDE; TUMOR ANTIGEN;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CROSS REACTION; CYTOTOXIC T LYMPHOCYTE; EPITHELIUM TUMOR; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VACCINIA VIRUS;

ANIMALS; BETA 2-MICROGLOBULIN; BINDING SITES; CARCINOEMBRYONIC ANTIGEN; CELL LINE; CROSS REACTIONS; EPITOPES, T-LYMPHOCYTE; HLA-B27 ANTIGEN; HUMANS; IMMUNIZATION; INTERFERON TYPE II; MICE; MICE, TRANSGENIC; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC; VACCINIA VIRUS;

EID: 0036131924     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1579     Document Type: Article

References (43)

1. Antigen recognition by class I-restricted T lymphocytes
2. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
3. Human tumor antigens recognized by T cells
4. Recognition of an antigenic peptide derived from tyrosinase-related protein-2 by CTL in the context of HLA-A31 and -A33
5. Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2)
6. The multi-epitope approach for immunotherapy for cancer: Identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial tumors
7. Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells
8. Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression
9. Identification of Her-2/Neu CTL epitopes using double transgenic mice expressing HLA-A2.1 and human CD.8
10. + T cell responses
11. Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles
12. Identification of a MAGE-2-encoded human leukocyte antigen-A24-binding synthetic peptide that induces specific antitumor cytotoxic T lymphocytes
13. Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives
14. Induction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunization with an engineered T-cytotoxic-T-helper synthetic peptide construct
15. T(h)1 but not T(h)0 cell help is efficient to induce cytotoxic T lymphocytes by immunization with short synthetic peptides
16. Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes
17. Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity
18. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
19. Induction of protective host immunity to carcinoembryonic antigen (CEA), a self-antigen in CEA transgenic mice, by immunizing with a recombinant vaccinia-CEA virus
20. Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine
21. Identification of potential HLA-A*0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA)
22. Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells
23. Identification of HLA-A24 epitope peptides of carcinoembryonic antigen which induce tumorreactive cytotoxic T lymphocyte
24. Expression of transgenic carcinoembryonic antigen (CEA) in tumor-prone mice: An animal model for CEA-directed tumor immunotherapy
25. Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy
26. Structure of class-I MHC molecules: HLA-B27 and disease
27. The peptide binding specificity of HLA-B27 subtypes
28. Analysis of HLA-B*2705 peptide motif, using T2 cells and monoclonal antibody ME1
29. Modulation of peptide binding by HLA-B27 polymorphism in pockets A and B, and peptide specificity of B*2703
30. HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides
31. HLA-restricted recognition of viral antigens in HLA transgenic mice
32. HLA class-I-transgenic mice as model system to study MHC-restricted antigen recognition in man
33. Solid phase peptide synthesis: I. The synthesis of a tetrapeptide
34. Peptide synthesis II: Procedures for solid phase synthesis using N-fluorenyl methoxycarbonyl aminoacids on polyamide supports: Synthesis of substance P and of acyl carrier protein 65-74 decapeptide
35. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides
36. Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions
37. Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection
38. A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA)
39. Characterization of an in situ IFN-gamma ELISA assay which is able to detect specific peptide responses from freshly isolated splenocytes induced by DNA minigene immunization
40. Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells
41. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes
42. Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome
43. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1