Induction of protective host immunity to carcinoembryonic antigen (CEA), a self-antigen in CEA transgenic mice, by immunizing with a recombinant vaccinia-CEA virus

Cancer Research

Volumn 59, Issue 3, 1999, Pages 676-683

  Kass, Erik ^a   Schlom, Jeffrey ^a   Thompson, John ^b   Guadagni, Fiorella ^c   Graziano, Paolo ^c   Greiner, John W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CANCER IMMUNIZATION; CANCER INHIBITION; CANCER PREVENTION; CANCER RESISTANCE; HOST RESISTANCE; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; VACCINIA VIRUS;

ANIMALS; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; CANCER VACCINES; CARCINOEMBRYONIC ANTIGEN; FEMALE; HUMANS; IMMUNITY, CELLULAR; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; VACCINATION; VACCINIA VIRUS;

EID: 0033083229     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Gold, P., and Freedman, S. O. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med., 121: 439-462, 1965.
2. Shuster, J., Thomson, D. M. P., Fuks, A., and Gold, P. Immunologic approaches to diagnosis of malignancy. Prog. Exp. Tumor Res., 25: 89-139, 1980.
3. Thompson, J. A., Grunert, F., and Zimmermann, W. Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J. Clin. Lab. Anal., 5: 344-366, 1991.
4. Shively, J. E., and Beatty, J. D. CEA-related antigens: molecular biology and clinical significance. Crit. Rev. Oncol. Hematol., 2: 355-399, 1985.
5. Hammarstrom, S., Olsen, A., Teglund, S., and Baranov, V. The nature and expression of the human CEA family. In: C. P. Scanners (ed.), Cell Adhesion and Communication Mediated by the CEA Family. Cell Adhesion and Communication Book Series, pp. 289-302. Amsterdam: Harwood Academic Publishers, 1998.
6. Benchimol, S., Fuks, A., Jothy, S., Beauchemin, N., Shirota, K., and Stanners, C. P. Carcinoembryonic antigen, a human tumor marker, functions as an intracellular adhesion molecule. Cell. 57: 327-334, 1989.
7. Leusch, H-G., Hefta, S. A., Drzeniek, Z., Hummel, K., Markos-Pusztai, Z., and Wagener, C. Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA). FEBS Lett., 261: 405-409, 1990.
8. Hostetter, R. B., Augustus, L. B., Mankarious, R., Chi, K., Fan, D., Toth, C., Thomas, P., and Jessup, J. M. Carcinoembryonic antigen as a selective enhancer of colorectal cancer metastasis. J. Natl. Cancer Inst., 82: 380-385, 1990.
9. Guadagni, F., Witt, P. L., Robbins, P., Schlom, J., and Greiner, J. W. Regulation of carcinoembryonic antigen expression in different human colorectal tumor cells by interferon-γ. Cancer Res., 50: 6248-6255, 1990.
10. Goldenberg, D. M., Kim, E. E., Deland, F. H., Bennett, S., and Primus, F. J. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Res., 40: 2984-2992, 1980.
11. Pressman, D., Ming, C. T., and Grossman, A. L. Carcinoembryonic antigen-binding immunoglobulin isolated from normal human serum by affinity chromatography. J. Natl. Cancer Inst., 62: 1367-1371, 1979.
12. Kapsopoulou-Dominos, K., and Anderer, F. A. Circulating carcinoembryonic antigen immune complexes in sera of patients with carcinomata of the gastrointestinal tract. Clin. Exp. Immunol., 35: 190-195, 1979.
13. Lejtenyi, C. M., Freedman, S. O., and Gold, P. Response of lymphocytes from patients with gastrointestinal cancer to the carcinoembryonic antigen of the digestive system. Cancer (Phila.), 28: 115-120, 1971.
14. Orefice, S., Fossati, E., Pietrojusti, E., and Bonfanti, G. Delayed cutaneous hypersensitivity reaction to carcinoembryonic antigen in patients. Tumori, 68: 473-475, 1982.
15. Koda, J., Glass, M. C., and Chang, H. R. Generation of human monoclonal antibodies against colon cancer. Arch. Surg., 125: 1591-1597, 1990.
16. Durrant, L. G., Denton, G. W. L., Jacobs, E., Mee, M., Moss, R., Austin, E. B., Baldwin, R. W., Hardcastle, J. D., and Robins, R. A. An idiotypic replica of carcinoembryonic antigen inducing cellular and humoral responses directed against human colorectal tumours. Int. J. Cancer, 50: 811-816, 1992.
17. Foon, K. A., Chakraborty, M., John, W. J., Sherratt, A., Kohler, H., and Bhattacharya-Chatterjee, M. Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine. J. Clin. Investig., 96: 334-342, 1995.
18. Tsang, K. Y., Zaremba, S., Nieroda, C. A., Zhu, M. Z., Hamilton, J. M., and Schlom, J. Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine. J. Natl. Cancer Inst., 87: 982-990, 1995.
19. Samanci, A., Yi, Q., Fagerberg, J., Strigard, K., Smith, G., Ruden, U., Wahren, B., and Mellstedt, H. Pharmacological administration of granulocyte/macrophage colony-stimulating factor is of significant importance for the induction of a strong humoral and cellular response in patients immunized with recombinant carcinoembryonic antigen. Cancer Immunol. Immunother. 47: 131-142, 1998.
20. Kaufman, H., Schlom, J., and Kantor, J. A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA). Int. J. Cancer. 48: 900-907, 1991.
21. Kantor, J., Irvine, K., Abrams, S., Kaufman, H., DiPietro, J., and Schlom, J. Antitumor activity and immune response induced by a recombinant carcinoembryonic antigen-vaccinia virus vaccine. J. Natl. Cancer Inst., 84: 1084-1091, 1992.
22. Hodge, J. W., McLaughlin, J. P., Abrams, S. I., Shupert, W. L., Schlom, J., and Kantor, J. A. Admixture of a recombinant vaccinia virus containing the gene for the costimulatory molecule B7 and a recombinant vaccinia virus containing a tumor-associated antigen gene results in enhanced specific T-cell responses and antitumor immunity. Cancer Res., 55: 3598-3603, 1995.
23. McLaughlin, J. P., Schlom, J., Kantor, J. A., and Greiner, J. W. Improved immunotherapy of a recombinant CEA vaccinia vaccine when given in combination with interleukin-2. Cancer Res., 56: 2361-2367, 1996.
24. Eades-Perner, A-M., van der Putten, H., Hirth, A., Thompson, J., Neumaier, M., von Kleist, S., and Zimmermann, W. Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern. Cancer Res., 54: 4169-4176, 1994.
25. Robbins, P. F., Kantor, J. A., Salgaller, M., Hand, P. H., Fernsten, P. D., and Schlom, J. Transduction and expression of the human carcinoembryonic antigen (CEA) gene in a murine colon carcinoma cell line. Cancer Res., 51: 3657-3662, 1991.
26. Muraro, R., Wunderlich, D., Thor, A., Lundy, J., Noguchi, P., Cunningham, R., and Schlom, J. Definition of monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinoma versus normal adult tissues. Cancer Res., 45: 5769-5780, 1985.
27. Schott, M. E., Wells, D. T., Schlom, J., and Abrams, S. I. Comparison of linear and branched peptides forms (MAPS) in the induction of helper responses to point mutated ras immunogens. Cell. Immunol., 174: 199-209, 1996.
28. Bristol, J. A., Schlom, J., and Abrams, S. I. Development of a murine mutant Ras CD8+ CTL peptide epitope variant that possesses enhanced MHC class I binding and immunogenic properties. J. Immunol., 160: 2433-2441, 1998.
29. Hsu, S. M., Raine, L., and Fanger, H. Use of avidin-biotin-peroxidase complex (ABS) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PA) procedures. J. Histochem. Cytochem., 29: 577-580, 1981.
30. Mosmann, T. R., Cherwinski, H., Bond, M. W., Geidlin, M. A., and Coffman, R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol., 136: 2348-2357, 1986.
31. Boon, T., Cerottini, J-C., Van den Eynde, B., van der Bruggen, P., and Van Pel, A. Tumor antigens recognized by T lymphocytes. Annu. Rev. Immunol., 12: 337-365, 1994.
32. Kantor, J., Irvine, K., Abrams, S., Snoy, P., Olsen, R., Greiner, J., Kaufman, H., Eggensberger, D., and Schlom, J. Immunogenicity and safety of a recombinant vaccinia virus vaccine expressing the carcinoembryonic antigen gene in a nonhuman primate. Cancer Res., 52: 6917-6925, 1992.
33. Hasegawa, T., Isobe, K., Tsuchiya, Y., Oikawa, S., Nakazato, H., Ikezawa, H., Nakashima, I., and Shimokata, K. Establishment and characterization of human carcinoembryonic antigen transgenic mice. Br. J. Cancer, 64: 710-714, 1991.
34. Clarke, P.., Mann, J., Simpson, J. F., Rickard-Dickson, K., and Primus, F. J. Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy. Cancer Res., 58: 1469-1477, 1998.
35. Eades-Perner, A-M., and Zimmerman, W. Carcinoembryonic antigen-transgenic mice: a model for tumor immunotherapy. Tumor Biol. 16: 56-61, 1995.
36. Sikorska, H., Shuster, J., and Gold, P. Clinical applications of carcinoembryonic antigen. Cancer Detect. Prev., 12: 321-355, 1988.
37. Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol., 12: 991-1045, 1994.
38. Mizobata, S., Clarke, P., Mann, J., Hefta, S. A., and Primus, F. J. Cytotoxic T cell responses for human carcinoembryonic antigen (CEA) epitopes in mice transgenic for HLA-A2.1Kb and human CEA. Proc. Am. Assoc. Cancer Res., 39: 84, 1998.
39. Coupar, B. E. H., Andrew, M. E., and Boyle, D. B. A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes. Gene (Amst.), 68: 1-10, 1988.
40. Smith, G. L., and Moss, B. Infectious poxvirus vectors have capacity for at least 25,000 base pairs of foreign DNA. Gene (Amst.) 25: 21-28, 1983.
41. Stephens, E. B., Compans, R. W., Earle, P., and Moss, B. Surface expression of viral glycoproteins is polarized in epithelial cells infected with recombinant vaccinia viral vectors. EMBO J., 5: 237-245, 1986.
42. Sarzotti, M., Robbins, D. S., and Hoffman, P. M. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science (Washington DC), 271: 1726-1728, 1996.
43. H2 immunity in neonatal mice. Science (Washington DC), 271: 1728-1730, 1996.
44. Ridge, J. P., Fuchs, E., and Matzinger, P. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science (Washington DC), 271; 1723-1726, 1996.
45. Gong, J., Chen, D., Kashiwaba, M., Li, Y., Chen, L., Takeuchi, H., Qu, H., Rowse, G. J., Gendler, S. J., and Kufe, D. Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc. Natl. Acad. Scil. USA, 95: 6279-6283, 1998.