Ezrin, radixin, and moesin are components of Schwann cell microvilli

Journal of Neuroscience Research

Volumn 65, Issue 2, 2001, Pages 150-164

  Scherer, Steven S ^a   Xu, Theodore ^b   Crino, Peter ^b   Arroyo, Edgardo J ^b   Gutmann, David H ^b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ERM proteins; Myelin; Neurofibromatosis; Nodes of Ranvier

Indexed keywords

EZRIN; MOESIN; RADIXIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; MICROVILLUS; MYELIN SHEATH; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RANVIER NODE; RAT; SCHWANN CELL; TUMOR SUPPRESSOR GENE;

ANIMALS; ANKYRINS; ANTIBODY SPECIFICITY; BLOOD PROTEINS; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; CYTOSKELETAL PROTEINS; IMMUNOHISTOCHEMISTRY; KV1.1 POTASSIUM CHANNEL; KV1.2 POTASSIUM CHANNEL; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; MICROFILAMENTS; MICROSCOPY, ELECTRON; MICROVILLI; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; NEUROFILAMENT PROTEINS; PERIPHERAL NERVES; PHOSPHOPROTEINS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RANVIER'S NODES; RATS; RNA, MESSENGER; SCHWANN CELLS; SCIATIC NERVE; SODIUM CHANNELS;

EID: 0035879768     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1138     Document Type: Article

References (59)

1. Radixin is a component of hepatocyte microvilli in situ
2. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment and cell-cell contacts
3. On the molecular architecture of myelinated fibers
4. Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvβ2, and Caspr
5. Molecular architecture of the specialized axonal membrane at the node of Ranvier
6. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cell whereas moesin is found primarily in endothelial cells
7. The perinodal astrocyte
8. Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor
9. Molecular characterization of the dendritic growth cone: Regulated mRNA transport and local protein synthesis
10. Normal development of mice and unimpaired cell adhesion cell motility actin-based cytoskeleton without compensatory upregulation of ezrin or radixin in moesin gene knockout
11. The axonal membrane protein Caspr/Neurexin IV is a component of the septate-like paranodal junctions that assemble during myelination
12. Novel E-cadherin mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions
13. β4 integrin expression in myelinating Schwann cells is ab-axonally polarized, developmentally regulated, and axonally dependent
14. Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins
15. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
16. Conditional biallelic NF2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2
17. Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas
18. Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues: Application of a novel fixation protocol using trichloroacetic acid (TCA) as a fixative
19. Molecular dissection of radixin: Distinct and interdependent functions of the amino- and carboxy-terminal domains
20. Morphology of central nervous system axons
21. Merlin differs from moesin in binding to F-actin and in its intra- and intermolecular interactions
22. Three dimensional fine structure of cytoskeletal-membrane interactions at nodes of Ranvier
23. Expression of CD44H in the cells of neural crest origin in peripheral nervous system
24. Regulation of the cell adhesion molecule CD44 after nerve transection and direct trauma to the mouse brain
25. Voltage-dependent membrane currents of cultured human neurofibromatosis type 2 Schwann cells
26. Organization of microtubules in myelinating Schwann cells
27. Monoclonal antibodies recognized individual neurofilament triplet proteins
28. Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats
29. Phosphorylation-dependent neurofilament epitopes are reduced at the node of Ranvier
30. Rho-kinase phosphorylates COOH terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
31. Differential distribution of closely related potassium channels in rat Schwann cells
32. + buffering are localized in microvilli of Schwann cells
33. + channels in rat sciatic nerve
34. Phosphorlyation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets
35. Merlin, the neurofibromatosis type 2 gene product, and β1 integrin associate in isolated and differentiating Schwann cells
36. Schwann cell-derived desert hedgehog controls the development of peripheral nerve sheaths
37. The myelin-associated glycoproteins: Membrane disposition, evidence of a novel disulfide linkage between immunoglobulin-like domains, and posttranslational palmitylation
38. Molecular domains of myelinated fibers
39. Differences between the nodes of Ranvier of large and small diameter fibres in the PNS
40. Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton
41. Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells
42. Connexin32 is a myelin-related protein in the PNS and CNS
43. Neurofibromatosis 2 tumour suppressor schwannomin interacts with beta II-spectrin
44. CD44 expression is aberrant in benign Schwann cell tumors possessing mutations in the neurofibromatosis type 2, but not type 1, gene
45. Interdomain binding mediates tumor growth suppression by the NF2 gene product
46. CD44 enhances neuregulin signaling by Schwann cells
47. Universal absence of merlin, but not other ERM family members, in schwannomas
48. Expression and regulation of α1β1 integrin in Schwann cells
49. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members
50. The dynamics of β1 integrin expression during peripheral nerve regeneration
51. Colocalization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibers
52. ERM (ezrin/radixin/moesin) family: From cytoskeleton to signal transduction
53. Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice
54. Wallerian degeneration in ICAM-1-deficient mice
55. Analysis of a cortical cytoskeletal structure: A role for erzin-radixin-moesin (ERM proteins) in the marginal band of chicken erythrocytes
56. Merlin differentially associates with the microtubule and actin cytoskeleton
57. Buffered picric-acid formaldehyde: A new rapid fixative for electron-microscopy