Effect of SMP-500, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on the cholesterol esterification and its hypocholesterolemic properties

Pharmacology

Volumn 65, Issue 1, 2002, Pages 18-25

  Ioriya, Katsuhisa ^a,b   Noguchi, Tsuyoshi ^a   Muraoka, Masami ^a   Fujita, Katsuya ^a   Shimizu, Hiroshi ^a   Ohashi, Naohito ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b NONE   (Japan)

Author keywords

ACAT activity; ACAT inhibitor; Cholesterol lowering effect; SMP 500

Indexed keywords

ACYLTRANSFERASE INHIBITOR; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; N [2,6 BIS(1 METHYLETHYL)PHENYL] N' [1 BUTYL 1,2 DIHYDRO 2 OXO 4 [3 (3 PYRIDYLMETHOXY)PHENYL] 1,8 NAPHTHYRIDIN 3 YL] UREA NITRATE; SMP 500; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL ESTERIFICATION; CHOLESTEROL LIVER LEVEL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; FEEDING; HAMSTER; HYPERCHOLESTEROLEMIA; HYPOCHOLESTEROLEMIA; IC 50; MICROSOME; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RABBIT; RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CELLS, CULTURED; CHOLESTEROL; CRICETINAE; ENZYME INHIBITORS; ESTERS; INTESTINES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICROSOMES; MICROSOMES, LIVER; NAPHTHYRIDINES; RABBITS; RATS; RATS, WISTAR; STEROL O-ACYLTRANSFERASE; UREA;

EID: 0036129561     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056181     Document Type: Article

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