Difference between normal and WHHL rabbits in susceptibility to the adrenal toxicity of an acyl-CoA:cholesterol acyltransferase inhibitor, FR145237

Toxicology and Applied Pharmacology

Volumn 140, Issue 2, 1996, Pages 387-392

  Matsuo, Masahiko ^a   Hashimoto, Masaharu ^a   Suzuki, Jyunya ^a   Iwanami, Kohki ^a   Tomoi, Masaaki ^a   Shimomura, Kyoichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 1 [[3 (4 CHLOROPHENYL) 5 METHYL 2 BENZOFURANYL]METHYL] 3 (2,4,6 TRIFLUOROPHENYL)UREA; ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; LOW DENSITY LIPOPROTEIN RECEPTOR; UNCLASSIFIED DRUG;

ADRENAL CORTEX; ADRENAL GLAND; ADRENAL MEDULLA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TOXICITY; HISTOCHEMISTRY; INFLAMMATORY CELL; INTRAVENOUS DRUG ADMINISTRATION; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; RABBIT; TISSUE NECROSIS; ZONA GLOMERULOSA;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0030273663     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0235     Document Type: Article

References (17)

1. Bocan, T. M. A., Mueller, S. B., Uhlendorf, P. D., Newton, R. S., and Krause, B. R. (1991). Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. Arteriosclerosis Thromb. 11, 1830-1843.
2. Brown, M. S., Ho, Y. K., and Goldstein, J. L. (1980). The cholesteryl ester cycle in macrophage foam cells. J. Biol. Chem. 255, 9344-9352.
3. Carr, T. P., Hamilton, R. L., Jr., and Rudel, L. L. (1995). ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys. J. Lipid Res. 36, 25-36.
4. Cianflone, K. M., Yasruel, Z., Rodriguez, M. A., Vas, D., and Sniderman, A. D. (1990). Regulation of apoB secretion from HepG2 cells: Evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge. J. Lipid Res. 31, 2045-2055.
5. Dietschy, J. M., Kita, T., Suckling, K. E., Goldstein, J. L., and Brown, M. S. (1983). Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors. J. Lipid Res. 24, 469-480.
6. Dominick, M. A., McGuire, E. J., Reindel, J. F., Bobrowski, W. F., Bocan, T. M. A., and Gough, A. W. (1993a). Subacute toxicity of a novel inhibitor of acyl-CoA: Cholesterol acyltransferase in beagle dogs. Fund. Appl. Toxicol. 20, 217-224.
7. Dominick, M. A., Bobrowski, W. A., MacDonald, J. R., and Gough, A. W. (1993b). Morphogenesis of a zone-specific adrenocortical cytotoxicity in guinea pigs administered PD132301-2, an inhibitor of acyl-CoA: Cholesterol acyltransferase. Toxicol. Pathol. 21, 54-62.
8. Gwynne, J. T., and Strauss, J. F., III (1982). The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocr. Rev. 3, 299-329.
9. Heider, J. G., Pickens, C. E., and Kelly, L. A. (1983). Role of acyl CoA: Cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit. J. Lipid Res. 24, 1127-1134.
10. Hoeg, J. M., Loriaux, L., Gregg, R. E., Green, W. R., and Brewer, H. B., Jr. (1985). Impaired adrenal reserve in the Watanabe heritable hyperlipidemic rabbit: Implications for LDL-receptor function in steroidogenesis. Metabolism 34, 194-197.
11. Kita, T., Brown, M. S., Watanabe, Y., and Goldstein, J. L. (1981). Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia. Proc. Natl. Acad. Sci. U.S.A. 78, 2268-2272.
12. Marzetta, C. A., Savoy, Y. E., Freeman, A. M., Long, C. A., Pettini, J. L., Hagar, R. E., Inskeep, P. B., Davis, K., Stucchi, A. F., Nicolosi, R. J., and Hamanaka, E. S. (1994). Pharmacological properties of a novel ACAT inhibitor (CP-113,818) in cholesterol-fed rats, hamsters, rabbits, and monkeys. J. Lipid Res. 35, 1829-1838.
13. Matsuo, M., Ito, F., Konto, A., Aketa, M., Tomoi, M., and Shimomura, K. (1995). Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall. Biochim. Biophys. Acta 1259, 254-260.
14. Suckling, K. E., and Stange, E. F. (1985). Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism. J. Lipid Res. 26, 647-671.
15. Tanaka, H., Ohtsuka, I., Kogushi, M., Kimura, T., Fujimori, T., Saeki, T., Hayashi, K., Kobayashi, H., Yamada, T., Hiyoshi, H., and Saito, I. (1994). Effect of the acyl-CoA: Cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis 107, 187-201.
16. Vernetti, L. A., MacDonald, J. R., Wolfgang, G. H. I., Dominick, M. A., and Pegg, D. G. (1993). ATP depletion is associated with cytotoxicity of a novel lipid regulator in guinea pig adrenocortical cells. Toxicol. Appl. Pharmacol. 118, 30-38.
17. Warner, G. J., Stoudt, G., Bamberger, M., Johnson, W. J., and Rothblat, G. H. (1995). Cell toxicity induced by inhibition of acyl coenzyme A: Cholesterol acyltransferase and accumulation of unesterified cholesterol. J. Biol. Chem. 270, 5772-5778.