Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs

Japanese Journal of Pharmacology

Volumn 73, Issue 1, 1997, Pages 41-50

  Kashiwa, Makoto ^a   Masuyama, Yoichi ^a   Miyauchi, Hiromi ^a   Uchida, Taisuke ^b   Naganuma, Shin ^a   Kakuta, Hirotoshi ^a   Terada, Motoko ^a   Kiriyama, Takashi ^a   Matsuda, Koyo ^a   Ito, Noriki ^a   Iizumi, Yuichi ^a   Takenaka, Toichi ^a  

^a Yamanouchi Inst Drug Discov Res   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Acyl CoA:cholesterol acyltransferase (ACAT) inhibitor; Cholesterol; Diarrhea; YM17E

Indexed keywords

1,3 BIS[[1 CYCLOHEPTYL 3 (4 DIMETHYLAMINOPHENYL)UREIDO]METHYL]BENZENE; BILE ACID; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER ENZYME; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID; STEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE FLOW; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIARRHEA; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG STRUCTURE; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; INTESTINE ABSORPTION; LIVER WEIGHT; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOSPHOLIPID BLOOD LEVEL; RAT; STEROL SYNTHESIS; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 15144356732     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.73.41     Document Type: Article

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