Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: Cholesterol O-acyltransferase, on human adrenocortical cells in culture

Biochemical Pharmacology

Volumn 61, Issue 4, 2001, Pages 387-398

  Junquero, Didier ^a   Pilon, Antoine ^b   Carilla Durand, Elizabeth ^a   Patoiseau, Jean François ^a   Tarayre, Jean Pierre ^a   Torpier, Gérard ^b   Staels, Bart ^b   Fruchart, Jean Charles ^b   Colpaert, Françis C ^a   Clavey, Véronique ^b   Delhon, André ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b INSERM   (France)

Author keywords

ACAT; Adrenal cells; Adrenal ultrastructure; F 12511; Lipid metabolism; Steroidogenesis

Indexed keywords

2',3',5' TRIMETHYL 4' HYDROXY ALPHA DODECYLTHIOPHENYLACETANILIDE; ALDOSTERONE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHOLESTEROL OLEATE; EFLUCIMIBE; FORSKOLIN; HYDROCORTISONE; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; STEROID 17ALPHA MONOOXYGENASE; STEROID 21 MONOOXYGENASE; UNCLASSIFIED DRUG;

ADRENAL CORTEX CELL; ARTICLE; CELL ULTRASTRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EXPOSURE; GENETIC TRANSCRIPTION; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIPID TRANSPORT; PRIORITY JOURNAL; STEROIDOGENESIS;

ADRENAL CORTEX NEOPLASMS; ADRENAL GLANDS; ANILIDES; BINDING SITES; BIOLOGICAL TRANSPORT; CELL SURVIVAL; CHOLESTEROL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; RECEPTORS, LIPOPROTEIN; STEROIDS; STEROL O-ACYLTRANSFERASE; TUMOR CELLS, CULTURED;

EID: 0035865448     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00555-4     Document Type: Article

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