15 deoxy Δ12,14 PGJ2 induces procoagulant activity in cultured human endothelial cells

Thrombosis and Haemostasis

Volumn 87, Issue 3, 2002, Pages 523-529

  Xie, Shaoping ^a   O'Regan, David J ^a   Kakkar, Vijay V ^a   Scully, Michael F ^a  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

Author keywords

15 deoxy 12,14 PGJ2; Endothelial cells; Peroxisome proliferator activated receptor ; Thrombomodulin; Tissue factor

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CIGLITAZONE; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN; PROTEIN C RECEPTOR; RECEPTOR; THROMBOMODULIN; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; AUTACOID; DRUG DERIVATIVE; PROSTAGLANDIN D2;

ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG INHIBITION; DRUG POTENTIATION; ENDOTHELIUM CELL; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; INFLAMMATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UMBILICAL VEIN; CHEMICALLY INDUCED DISORDER; CYTOLOGY; PATHOLOGY; THROMBOPHILIA; UMBILICAL CORD; VASCULAR ENDOTHELIUM;

CELLS, CULTURED; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION MEDIATORS; MAP KINASE SIGNALING SYSTEM; PHENOTYPE; PROSTAGLANDIN D2; THROMBOMODULIN; THROMBOPHILIA; THROMBOPLASTIN; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL CORD;

EID: 0036121601     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613034     Document Type: Article

References (33)

1. 2. Identification of products formed in vitro
2. 2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
3. 2 is a ligand for the adipocyte determination factor PPAR gamma
4. Peroxisome proliferator-activated receptors in the cardiovascular system
5. Inducible cyclooxygenase may have anti-inflammatory properties
6. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: Characterization and comparison with the actions of interleukin 1
7. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture
8. Regulation of endothelial cell coagulant properties. Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor
9. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
10. PPAR-gamma agonists: Therapeutic role in diabetes, inflammation and cancer
11. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
12. Endothelium specific Weibel-Palade bodies in a continuous human cell line, EA.hy926
13. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
14. Vitamin D derivatives inhibit the mitogenic effects of IGF-I on MCF-7 human breast cancer cells
15. Annexin V as a probe of the contribution of anionic phospholipids to the procoagulant activity of tumour cell surfaces
16. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
17. Anticoagulant effects of retinoic acids on leukemia cells
18. Cellular effects of heparin on the production and release of tissue factor pathway inhibitor in human endothelial cells in culture
19. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2
20. Apoptotic vascular endothelial cells become procoagulant
21. Vascular endothelial cell growth factor-induced tissue factor expression in endothelial cells is mediated by EGR-1
22. Regulation of thrombomodulin by tumor necrosis factor-alpha: Comparison of transcriptional and posttranscriptional mechanisms
23. Cell biology of tissue factor, the principal initiator of blood coagulation
24. PPAR alpha activators inhibit tissue factor expression and activity in human monocytes
25. Regulation of the tissue factor promoter in endothelial cells. Binding of NF kappa B-, AP-1-, and Sp1-like transcription factors
26. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites
27. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
28. 2 inhibits multiple steps in the NF-kappa B signaling pathway
29. Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells
30. A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPAR-gamma
31. Regulation of the tissue factor gene
32. Metalloproteolytic release of endothelial cell protein C receptor
33. Progress in cardiovascular biology: PPAR for the course