VH gene analysis in sporadic Burkitt's lymphoma: Somatic mutation and intraclonal diversity with special reference to the tumor cells involving germinal center

Leukemia and Lymphoma

Volumn 43, Issue 1, 2002, Pages 159-164

  Isobe, Kouichi ^d   Tamaru, Jun Ichi ^a   Nakamura, Shigeo ^b   Harigaya, Kenichi ^c   Mikata, Atsuo ^c   Ito, Hisao ^c  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NONE

Author keywords

Germinal center; Homing; Intraclonal diversity; sBL; Somatic mutation; VH gene

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M;

ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BURKITT LYMPHOMA; CHROMOSOME MICRODISSECTION; CLINICAL ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC COMPLEMENTATION; GENETIC SELECTION; GERM LINE; GERMINAL CENTER; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOSTIMULATION; MEMORY CELL; MUTATION RATE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR CELL; TUMOR GROWTH; AMINO ACID SEQUENCE; CELL CLONE; COMPLEMENTARITY DETERMINING REGION; GENETIC VARIABILITY; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MOLECULAR GENETICS; MUTATION; PATHOLOGY;

AMINO ACID SEQUENCE; BURKITT LYMPHOMA; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; DNA MUTATIONAL ANALYSIS; GENE REARRANGEMENT; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; MOLECULAR SEQUENCE DATA; MUTATION; VARIATION (GENETICS);

EID: 0036121581     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190210199     Document Type: Article

References (40)

1. "Identification of a subset of normal B cells with a Burkitt's lymphoma-like phenotype"
2. "Non endemic Burkitt's lymphoma: A B-cell tumor related to germinal centers"
3. "A revised European-American classification of lymphoid neoplasms: A proposal from the international Lymphoma Study Group"
4. "What is Burkitt's lymphoma?"
5. "Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis"
6. "Intraclonal offspring expression of gastric low-grade MALT-type lymphoma: Evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis"
7. "Ongoing somatic mutations and clonal expressions after cure of Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue B-cell lymphoma"
8. "Ongoing immunoglobulin gene mutations in mantle cell lymphomas"
9. "Ongoing somatic mutation in mantle cell lymphomas questioned"
10. "Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas"
11. H genes with no or very little somatic mutations like the physiologic cells of the follicle mantle"
12. H genes"
13. H rearrangements"
14. "Somatic hypermutation in normal and transformed human B cells"
15. "Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes"
16. "Evidence for a large compartment of IgM-expressing memory B cells in humans"
17. H genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity"
18. "The absence of ongoing immunoglobulin gene hypermutation suggests a distinct mechanism for c-myc mutation in endemic Burkitt's lymphoma"
19. H genes with a moderate number of antigen-selected somatic mutations"
20. L gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection"
21. "A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma"
22. "Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections"
23. "Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes"
24. "Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: Intraclonal stability is frequent but not constant"
25. H genes expressed by CD5-chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor"
26. "Somatic mutation of human immunoglobulin V genes in the X-linked hyperIgM syndrome"
27. "Affinity maturation without germinal centers in lymphotoxin-α-deficient mice"
28. "The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes"
29. H) region diversity generated by VH gene replacement in the progeny of single precursor cell transformed with a temperature-sensitive mutant of Abelson murine leukemia virus"
30. "Mutation analysis of the rearranged immunoglobulin heavy chain genes of marginal zone cell lymphomas indicates an origin from different marginal zone B lymphocyte subsets"
31. "Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes"
32. "Analysis of the B-cell progenitor compartment at the level of single cells"
33. H region of the immunoglobulin heavy chain locus"
34. H gene rearrangements"
35. "Distinct ongoing Ig heavy chain rearrangement processes in childhood B precursor acute lymphoblastic leukemia"
36. "Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia"
37. "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma"
38. "The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues"
39. "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen"
40. "Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells"