The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: Experience from a regional perfusion technique

European Journal of Pharmaceutical Sciences

Volumn 15, Issue 3, 2002, Pages 271-277

  Lennernas H ^a   Knutson, L ^a   Knutson, T ^a   Hussain, A ^b   Lesko, L ^b   Salmonson, T ^c   Amidon, G L ^d  

^a UPPSALA UNIVERSITY   (Sweden)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c Medical Product Agency   (Sweden)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Absorption interaction; Amiloride; Amoxicillin; Bioavailability; Bioequivalence; Biopharmaceutics Classification System; Drug absorption; In vivo transport; Intestinal drug permeability; Oligopeptide carrier; PepT1

Indexed keywords

ABSORPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

SINGLE-PASS PERFUSION;

ANTIBIOTICS;

AMILORIDE; AMOXICILLIN; BETA LACTAM ANTIBIOTIC; CARBON 14; MACROGOL 4000; PHENAZONE;

ACTIVE TRANSPORT; ADULT; ARTICLE; CELL MEMBRANE PERMEABILITY; CLASSIFICATION; CONTROLLED STUDY; DIFFUSION; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG STABILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; JEJUNUM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REGIONAL PERFUSION; SMALL INTESTINE ABSORPTION; STANDARD; TECHNIQUE; TUBE; VOLUNTEER;

NON-PROGRAMMATIC;

ADULT; AMILORIDE; AMOXICILLIN; DIURETICS; DRUG INTERACTIONS; DRUG STABILITY; FEMALE; HUMANS; INTESTINAL ABSORPTION; JEJUNUM; MALE; PENICILLINS; PERFUSION; PERMEABILITY;

EID: 0036118602     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00005-2     Document Type: Article

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