Antihypertensive effects of a mixed endothelin-A- and -B-Receptor antagonist, J-104132, were augmented in the presence of an AT1-receptor antagonist, MK-954

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Ikeda, T ^a   Ohta, H ^a   Okada, M ^a   Kawai, N ^a   Nakao, R ^a   Siegl, P K S ^a   Kobayashi, T ^a   Miyauchi, T ^a   Nishikibe, M ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Dahl salt sensitive rats; Endothelin (ET); J 104132 (L 753,037); Losartan (MK 954); Spontaneously hypertensive rat (SHR)

Indexed keywords

2 BUTYL 7 [2 (2 CARBOXYPROPYL ) 4 METHOXYPHENYL] 5 (3,4 METHYLENEDIOXYPHENYL)CYCLOPENTENO[1,2 B]PYRIDINE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; L 753 037; LOSARTAN POTASSIUM; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; AORTA; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; GENE EXPRESSION; HYPERTENSION; KIDNEY; MALE; MONOTHERAPY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SALT INTAKE; STRAIN DIFFERENCE;

EID: 0033743313     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ET(A)/ET(B) endothelin receptor antagonist
2. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
3. Pathophysiological roles of endothelin-1 in Dahl salt-sensitive hypertension
4. Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model
5. Chronic endothelin receptor antagonist treatment of young spontaneously hypertensive rats
6. ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension
7. Role of endothelin-1 and the ET(A) receptor in the maintenance of deoxycorticosterone acetate-salt-induced hypertension
8. Activation of endothelin ET(A) receptors masks the constrictor role of endothelin ET(B) receptors in rat isolated small mesenteric arteries
9. Evidence for endothelin-induced renal vasoconstriction independent of ETA receptor activation
10. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats
11. Effects of chronic ET(A)-receptor blockade in angiotensin II-induced hypertension
12. Losartan reduces constrictor responses to endothelin-1 and the thromboxane A2 analogue in aortic rings from spontaneously hypertensive rats: Role of nitric oxide
13. Effect of endothelin antagonism on blood pressure and vascular structure in renovascular hypertensive rats