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Volumn 8, Issue 5, 2002, Pages 1045-1050

Impact of two weekly schedules of oral eniluracil given with fluorouracil and leucovorin on the duration of dihydropyrimidine dehydrogenase inhibition

(8) Keith, Bruce a Guo, Xiao Du a Zentko, Suzanne a Harold, Nancy a Schuler, Barbara a Quinn, Mary a Shapiro, Jeremy a Grem, Jean L a

a NATIONAL CANCER INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYNYLURACIL; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; FOLINIC ACID; URACIL;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FEMALE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MALE; MASS SPECTROMETRY; MONONUCLEAR CELL; PANCREAS CANCER; PHARMACODYNAMICS; PLASMA; PRIORITY JOURNAL; SOLID TUMOR;

ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DIHYDROURACIL DEHYDROGENASE (NADP); DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NEOPLASMS; OXIDOREDUCTASES; TIME FACTORS; URACIL;

EID: 0036096947 PISSN: 10780432 EISSN: None Source Type: Journal
DOI: None Document Type: Article

Times cited : (4)

References (32)

1
- 0002685062
- 5-Fluorinated pyrimidines
- B. A. Chabner and D. L. Longo (eds.). Philadelphia: Lippincott-Raven Publishers
- (1996) Cancer Chemotherapy and Biotherapy: Principles and Practice , pp. 149-210
- Grem, J.L.¹

2
- 0022400840
- Enzymes of uracil catabolism in normal and neoplastic human tissues
- (1985) Cancer Res. , vol.45 , pp. 5405-5412
- Naguib, F.N.M.¹ El Kouni, M.H.² Cha, S.³

3
- 0026701936
- Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil
- (1992) J. Biol. Chem. , vol.267 , pp. 5236-5242
- Porter, D.J.¹ Chestnut, W.G.² Merrill, B.M.³ Spector, T.⁴

4
- 0027489763
- 5-Ethynyluraci] (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil
- (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11064-11068
- Baccanari, D.P.¹ Davis, S.T.² Knick, V.C.³ Baccanari, D.P.⁴ Davis, S.T.⁵ Knick, V.C.⁶ Spector, T.⁷

5
- 0027135995
- 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
- (1993) Biochem. Pharmacol. , vol.46 , pp. 2243-2248
- Spector, T.¹ Harrington, J.A.² Porter, D.J.³

6
- 10544243363
- Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
- (1996) J. Clin. Oncol. , vol.14 , pp. 3085-3096
- Baker, S.D.¹ Khor, S.P.² Adjei, A.A.³ Doucette, M.⁴ Spector, T.⁵ Donehower, R.C.⁶ Grochow, L.B.⁷ Sartorius, S.E.⁸ Noe, D.A.⁹ Hohneker, J.A.¹⁰ Rowinsky, E.K.¹¹

7
- 0031900670
- Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer
- (1998) J. Clin. Oncol. , vol.16 , pp. 1450-1457
- Schilsky, R.L.¹ Hohneker, J.² Ratain, M.J.³ Janisch, L.⁴ Smetzer, L.⁵ Lucas, V.S.⁶ Khor, S.P.⁷ Diasio, R.⁸ Von Hoff, D.D.⁹ Burris, H.A.¹⁰

8
- 0033758470
- Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies
- (2000) Ann. Oncol. , vol.11 , pp. 1313-1322
- Ochoa, L.¹ Hurwitz, H.I.² Wilding, G.³ Cohen, D.⁴ Thomas, J.P.⁵ Schwartz, G.⁶ Monroe, P.⁷ Petros, W.P.⁸ Ertel, V.P.⁹ Hsieh, A.¹⁰ Hoffman, C.¹¹ Drengler, R.¹² Magnum, S.¹³ Rowinsky, E.K.¹⁴

9
- 0033975358
- Rowinsky pharmacologic study of oral fluorouracil on a chronic daily schedule in combination with the dihydropyrimidine dehydrogenase inactivator eniluracil
- (2000) J. Clin. Oncol. , vol.18 , pp. 915-926
- Baker, S.D.¹ Diasio, R.B.² O'Reilly, S.³ Lucas, V.S.⁴ Khor, S.P.⁵ Sartorius, S.E.⁶ Donehower, R.C.⁷ Grochow, L.B.⁸ Spector, T.⁹ Hohneker, J.A.¹⁰ Rowinsky, E.K.¹¹

10
- 0034551725
- Takimoto pharmacokinetic trial of weekly oral fluorouracil given with eniluracil and low-dose leucovorin to patients with solid tumors
- (2000) J. Clin. Oncol. , vol.18 , pp. 3952-3963
- Grem, J.L.¹ Harold, N.² Shapiro, J.³ Bi, D.⁴ Quinn, M.G.⁵ Zentko, S.⁶ Keith, B.⁷ Hamilton, J.M.⁸ Monahan, B.P.⁹ Donavan, S.¹⁰ Grollman, F.¹¹ Morrison, G.¹² Takimoto, C.H.¹³

11
- 0006038804
- Research Triangle Park, NC: Glaxo Wellcome Clinical Oncology Group, June
- (1999) Investigator's Brochure: 776C85 Tablets and 5-Fluorouracil Tablets

12
- 0026490284
- Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin and interferon α-2a
- (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1820-1825
- Yee, L.K.¹ Allegra, C.J.² Steinberg, S.M.³ Grem, J.L.⁴

13
- 0033975442
- Measurement of plasma uracil using gas chromatography-mass spectrometry in normal individuals and in patients receiving inhibitors of dihydropyrimidine dehydrogenase
- (2000) J. Chromatogr. B Biomed. Sci. Appl. , vol.738 , pp. 249-258
- Bi, D.¹ Anderson, L.W.² Shapiro, J.³ Shapiro, A.⁴ Grem, J.L.⁵ Takimoto, C.H.⁶

14
- 0027534425
- Dihydropyrimidine dehydrogenase activity in cancer patients
- (1993) Eur. J. Cancer , vol.29 A , pp. 740-744
- Fleming, R.A.¹ Milano, G.A.² Gaspard, M.H.³ Bargnoux, P.J.⁴ Thyss, A.⁵ Plagne, R.⁶ Renee, N.⁷ Schneider, M.⁸ Demard, F.⁹

15
- 0028805308
- Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy
- (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 512-522
- Lu, Z.¹ Zhang, R.² Diasio, R.B.³

16
- 0000610778
- Dihydropyrimidine dehydrogenase rapidly regenerates after inactivation by eniluracil (776C85) in primary and metastatic colorectal cancer
- (2000) Proc. Am. Soc. Clin. Oncol. , vol.19 , pp. 682
- Heslin, M.J.¹ Yan, J.² Shao, L.³ Weingarten, J.⁴ Mangum, S.G.⁵ Ertel, P.J.⁶ Lucas, V.S.⁷ Diasio, R.B.⁸

17
- 0033770384
- Clinical development of eniluracil/fluorouracil: An oral treatment for patients with solid tumors
- (2000) Invest. New Drugs , vol.18 , pp. 383-390
- Levin, J.¹ Hohneker, J.²

18
- 0033049035
- Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer
- (1999) Clin. Cancer Res. , vol.5 , pp. 291-298
- Humerickhouse, R.A.¹ Dolan, M.E.² Haraf, D.J.³ Brockstein, B.⁴ Stenson, K.⁵ Kies, M.⁶ Sulzen, L.⁷ Ratain, M.J.⁸ Vokes, E.E.⁹

19
- 0032896143
- In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy
- (1999) Cancer Res. , vol.59 , pp. 122-127
- Adams, E.R.¹ Leffert, J.J.² Craig, D.J.³ Spector, T.⁴ Pizzorno, G.⁵

20
- 0034308181
- Validation of fluorouracil metabolite analysis in excised tumor. Lability of anabolites
- (2000) Biochem. Pharmacol. , vol.60 , pp. 963-967
- Bading, J.R.¹ Shahinian, A.H.² Paff, M.T.³ Yoo, P.B.⁴ Hsia, D.W.⁵

21
- 0035393729
- Extraction of 5-fluorouracil by tumor and liver: A noninvasive positron emission tomography study of patients with gastrointestinal cancer
- (2001) Cancer Res. , vol.61 , pp. 4937-4941
- Aboagye, E.O.¹ Saleem, A.² Cunningham, V.J.³ Osman, S.⁴ Price, P.M.⁵

22
- 0034679322
- Modulation of fluorouracil tissue pharmacokinetics by eniluracil: In vivo imaging of drug action
- (2000) Lancet , vol.355 , pp. 2125-2131
- Saleem, A.¹ Yap, J.² Osman, S.³ Brady, F.⁴ Suttle, B.⁵ Lucas, S.V.⁶ Jones, T.⁷ Price, P.M.⁸ Aboagye, E.O.⁹

23
- 0028488847
- Prevention of drug interactions and its countermeasures
- (1994) J. Toxicol. Sci. , vol.19 , pp. 89-93
- Nakamura, H.¹ Omori, S.² Kitada, K.³ Mochida, A.⁴

24
- 0030951083
- The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster
- (1997) Clin. Pharmacol. Ther. , vol.61 , pp. 563-573
- Yan, J.¹ Tyring, S.K.² McCrary, M.M.³ Lee, P.C.⁴ Haworth, S.⁵ Raymond, R.⁶ Olsen, S.J.⁷ Diasio, R.B.⁸

25
- 0032470250
- A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs
- (1998) J. Pharmacol. Exp. Ther. , vol.287 , pp. 791-799
- Okuda, H.¹ Ogura, K.² Kato, A.³ Takubo, H.⁴ Watabe, T.⁵

26
- 0031858786
- Sorivudine and 5-fluorouracil: A clinically significant drug-drug interaction due to inhibition of dihydropyrimidine dehydrogenase
- (1998) Br. J. Clin. Pharmacol. , vol.46 , pp. 1-4
- Diasio, R.B.¹

27
- 0031912432
- Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: Implication for 5-fluorouracil-based chemotherapy
- (1998) Clin. Cancer Res. , vol.4 , pp. 325-329
- Lu, Z.¹ Zhang, R.² Carpenter, J.T.³ Diasio, R.B.⁴

28
- 0000163968
- Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity
- (1999) Br. J. Cancer , vol.79 , pp. 627-630
- Milano, G.¹ Etienne, M.C.² Pierrefite, V.³ Barberi-Heyob, M.⁴ Deporte-Fety, R.⁵ Renee, N.⁶

29
- 0031010583
- Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells
- (1997) Cancer Chemother. Pharmacol. , vol.40 , pp. 117-125
- Grem, J.L.¹ Yee, L.K.² Venzon, D.J.³ Takimoto, C.H.⁴ Allegra, C.J.⁵

30
- 0032784111
- Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal tumors
- (1999) J. Clin. Oncol. , vol.17 , pp. 2439-2445
- Ahmed, F.Y.¹ Johnston, S.J.² Cassidy, J.³ O'Kelly, T.⁴ Binnie, N.⁵ Murray, G.I.⁶ Van Gennip, A.H.⁷ Abeling, N.G.G.M.⁸ Knight, S.⁹ McLeod, H.L.¹⁰

31
- 0003300519
- International Phase III study of oral eniluracil plus 5-fluorouracil versus intravenous 5-FU plus leucovorin in the treatment of advanced colorectal cancer
- (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 522
- Van Cutsem, E.¹ Sorensen, J.² Cassidy, J.³ Daniel, F.⁴ Harper, P.⁵ Bailey, N.⁶ Peachey, M.⁷ Somerville, M.⁸

32
- 0003300519
- North American Phase III study of oral eniluracil plus oral 5-fluorouracil versus intravenous 5-FU plus leucovorin in the treatment of advanced colorectal cancer
- (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 523
- Levin, J.¹ Schilsky, R.² Burris, H.³ Wong, A.⁴ Colwell, B.⁵ Thirlwell, M.⁶ Ansari, R.⁷ Bell, W.⁸ White, R.⁹ McGuirt, P.¹⁰ Hohneker, J.¹¹ Pazdur, R.¹²

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