The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3

Genomics

Volumn 40, Issue 1, 1997, Pages 200-202

  Seib, Thomas ^a   Blin, Nikolaus ^b   Hilgert, Karin ^a   Seifert, Markus ^a   Theisinger, Birgit ^a   Engel, Matthias ^a   Dooley, Steven ^a   Zang, Klaus Dieter ^a   Welter, Cornelius ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TREFOIL PEPTIDE;

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 21Q; DNA SEQUENCE; GENE LOCATION; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

LOTUS;

EID: 0031568905     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1996.4511     Document Type: Article

References (12)

1. 1. Hanby, A. M., Poulsom, R., Singh, S., Elia, G., Jeffery, R. E., and Wright, N. A. (1993). Spasmolytic polypeptide is a major antral peptide: Distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology 105: 1110-1116.
2. 2. Jeffrey, G. P., Oates, P. S., Wang, T. C., Babyatsky, M. W., and Brand, S. J. (1994). Spasmolytic polypeptide: A trefoil peptide secreted by rat gastric mucous cells. Gastroenterology 106: 336-345.
3. 3. Jeltsch, J. M., Roberts, M., Schatz, C., Garnier, J., Brown, A., and Chambon, P. (1987). Structure of the human oestrogen-responsive gene pS2. Nucleic Acids Res. 15: 1401-1414.
4. 4. Mashimo, H., Podolsky, D.H., and Fishman, M. C. (1995). Structure and expression of murine intestinal trefoil factor: High evolutionary conservation and postnatal expression. Biochem. Biophys. Res. Commun. 210: 31-37.
5. 5. Sands, B. E., Ogata, H., Lynch-Devaney, K., DeBeaumont, M., Ezzell, R. M., and Podolsky, D. K. (1995). Molecular cloning of the rat intestinal trefoil factor gene. Characterization of an intestinal goblet cell-associated promoter. J. Biol. Chem. 270: 9353-9361.
6. 6. Seib, T., Dooley, S., and Welter, C. (1995). Characterization of the genomic structure and the promoter region of the human intestinal trefoil factor. Biochem. Biophys. Res. Commun. 214: 195-199.
7. 7. Seitz, G., Theisinger, B., Tomasetto, G., Rio, M. C., Chambon, P., Blin, N., and Welter, G. (1991). Breast cancer-associated protein pS2 expression in tumors of the biliary tract. Am. J. Gastroenterol. 86: 1491-1494.
8. 8. Theisinger, B., Welter, C., Seitz, G., Rio, M. C., Lathe, R., Chambon, P., and Blin, N. (1991). Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma. Eur. J. Cancer 27: 770-773.
9. 9. Thim, L. (1994). Trefoil peptides: A new family of gastrointestinal molecules. Digestion 55: 353-360.
10. 10. Tomasetto, C., Rio, M. C., Gautier, C., Wolf, C., Hareuveni, M., Chambon, P., and Lathe, R. (1990). hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J. 9: 407-414.
11. 11. Tomasetto, C., Rockel, N., Mattei, M. G., Fujita, R., and Rio, M. C. (1992). The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2. Genomics 13: 1328-1330.
12. 12. Welter, C., Theisinger, B., Seitz, G., Tomasetto, C., Rio, M. C., Chambon, P., and Blin, N. (1992). Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma. Lab. Invest. 66: 187-192.