Molecular aspects of restitution: Functions of trefoil peptides

Yale Journal of Biology and Medicine

Volumn 69, Issue 2, 1996, Pages 137-146

  Poulsom, Richard ^a   Begos, Denis E ^b   Modlin, Irvin M ^b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACETYLSALICYLIC ACID; INDOMETACIN; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT PROTEIN; TREFOIL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; DUODENUM ULCER; EPITHELIUM CELL; HUMAN; INTESTINE RESECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; STOMACH ULCER; ULCER HEALING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DIVISION; DRUG SYNERGISM; EPIDERMAL GROWTH FACTOR; EPITHELIUM; GASTRIC MUCOSA; GROWTH SUBSTANCES; HUMANS; INDOMETHACIN; INTESTINAL MUCOSA; INTESTINES; MUCINS; MUSCLE PROTEINS; NEUROPEPTIDES; PEPTIDES; PROTEINS; RATS; STOMACH; STOMACH ULCER; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; LOTUS; RODENTIA;

EID: 0030432051     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Lacy, E.R., Morris, G.P., and Cohen, M.M. Rapid repair of the surface epithelium in human gastric mucosa after acute superficial injury. J Clin Gastroenterol. 17(Suppl 1):S125-S135, 1993.
2. Dignass, A., Lynch-Devaney, K., Kindon, H., Thim, L., and Podolsky, D.K. Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. J. Clin. Invest. 94:376-383, 1994.
3. Dignass, A.U. and Podolsky, D.K. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology. 105:1323-1332, 1993.
4. Kato, K., Chen, M.C., Lehman, F., Nguyen, M., Nakajima, N., Kuwayama, H., Arakawa, Y., and Soll, A.H. Trefoil peptides, IGF-I and basic FGF stimulate restitution in primary cultures of canine oxyntic mucosal cells. Gastroenterology. 108:A130-A130, 1995.
5. Huttenlocher, A., Sandborg, R.R., and Horwitz, A.F. Adhesion in cell migration. Curr. Opin. Cell Biol. 7:697-706, 1995.
6. Szabo, S., Kusstatscher, S., Sandor, Z., and Sakoulos, G. Molecular and cellular basis of ulcer healing. Scand. J. Gastroenterol. 30(Suppl 208):3-8, 1995.
7. Schmassmann, A., Tarnawski, A., Peskar, B., Varga, L., Flogerzi, B., and Halter, F. Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin. Amer. J. Physiol. 268 (Gastrointest. Liver Physiol. 31):G276-G285, 1995.
8. Hull, M.A., Cullen, D.J.E., Hudson, N., and Hawkey, C.J. Basic fibroblast growth factor treatment for non-steroidal anti-inflammatory drug associated gastric ulceration. Gut 37:610-612, 1995.
9. Poulsom, R. and Wright, N. A. Trefoil Peptides: a newly recognized family of epithelial mucin-associated molecules. Amer. J. Physiol. (Gastrointestinal and Liver Physiol.). 265:G205-G213, 1993.
10. Hoffmann, W. and Hauser, F. The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia? Trends in Biological Sciences 18:239-243, 1993.
11. Thim, L. A new family of growth factor-like peptides. "Trefoil" disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins). FEBS Lett. 250:85-90, 1989.
12. De, A., Brown, D.G., Gorman, M.A., Carr, M., Sanderson, M.R., and Freemont, P.S. Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors. Proc. Natl. Acad. Sci. USA 91:1084-1088, 1994.
13. Carr, M.D., Bauer, C.J., Gradwell, M.J., and Feeney, J. Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein. Proc. Natl. Acad. Sci. USA. 91:2206-2210, 1994.
14. Rio, M., Bellocq, J.P., Daniel, J.Y., Tomasetto, C., Lathe, R., Chenard, M.P., Batzenschlager, A., and Chambon, P. Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. Science 241:705-8, 1988.
15. Lefebvre, O., Wolf, C., Kédinger, M., Chenard, M., Tomasetto, C., Chambon, P., and Rio, M. The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. J. Cell Biol. 122:191-198, 1993.
16. Tomasetto, C., Rio, M., Gautier, C., Wolf, C., Hareuveni, M., Chambon, P., and Lathe, R. hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. Embo. J. 9:407-14, 1990.
17. Wright, N.A., Poulsom, R., Stamp, G.W., Hall, P.A., Jeffery, R.E., Longcroft, J.M., Rio, M., Tomasetto, C., and Chambon, P. Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues. J. Pathol. 162:279-84, 1990.
18. Jeffrey, G.P., Oates, P.S., Wang, T.C., Babyatsky, M.W., and Brand, S.J. Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric mucous cells. Gastroenterology 106:336-345, 1994.
19. Hanby, A.M., Poulsom, R., Singh, S., Elia, G., Jeffery, R.E., and Wright, N.A. Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology 105:110-1116, 1993.
20. Rasmussen, T.N., Raaberg, L., Poulsen, S.S., Thim, L., and Hoist, J.J. Immunohistochernical localization of pancreatic spasmolytic polypeptide (PSP) in the pig. Histochemistry 98:113-119, 1992.
21. Elia, G., Chinery, R., Hanby, A.M., Poulsom, R., and Wright, N.A. The production and characterization of a new monoclonal antibody to the trefoil peptide human spasmolytic polypeptide. Histochem. J. 26:644-647, 1994.
22. Suemori, S., Lynch-Devaney, K., and Podolsky, D.K. Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family. Proc. Natl. Acad. Sci. USA 88:11017-21, 1991.
23. Chinery, R., Poulsom, R., Rogers, L.A., Jeffery, R.E., Longcroft, J.M., Hanby, A.M., and Wright, N.A. Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ. Biochem. J. 285:5-8, 1992.
24. Hauser, F., Poulsom, R., Chinery, R., Rogers, L.A., Hanby, A.M., Wright, N.A., and Hoffmann, W. hPl .B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed in the ulcer associated cell lineage and the uterus. Proc. Natl. Acad. Sci. USA 90:6961-6965, 1993.
25. Podolsky, D.K., Lynch-Devaney, K., Stow, J.L., Oates, P., Murgue, B., DeBeaumont, M., Sands, B.E., and Mahida, Y.R. Identification of human intestinal trefoil factor: goblet cell-specific expression of a peptide targeted for apical secretion. J, Biol. Chem. 268:6694-6702, 1993.
26. Tomita, M., Itoh, H., Ishikawa, N., Higa, A., Ide, H., Murakumo, Y., Maruyama, H., Koga, Y., and Nawa, Y. Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes. Biochem. J. 311:293-297, 1995.
27. Bonkhoff, H., Stein, U., Welter, C., and Remberger, K. Differential expression of the pS2 protein in the human prostate and prostate cancer: association with premalignant changes and neuroendocrine differentiation. Hum. Pathol. 26:824-828, 1995.
28. Wright, N.A., Poulsom, R., Stamp, G., van Noorden, S., Sarraf, C., Elia, G., Ahnen, D., Jeffery, R., Longcroft, J., Pike, C., Rio, M., and Chambon, P. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Scand. J. Gastroenterol. 27:76-82, 1992.
29. Hauser, F., Gertzen, E.M , and Hoffmann, W. Expression of spasmolysin (FIM-A.1): an integumentary mucin from Xenopus laevis. Exp. Cell Res. 189:157-62, 1990.
30. Wright, N.A., Poulsom, R., Stamp, G., van Noorden, S., Sarraf, C., Elia, G., Ahnen, D., Jeffery, R., Longcroft, J., Pike, C., Rio, M., and Chambon, P. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterology. 104:12-20, 1993.
31. Poulsom, R., Chinery, R., Sarraf, C., Lalani, E.-N., Stamp, G., Elia, G., and Wright, N. Trefoil peptide gene expression in intestinal adaptation and renewal. Scand. J. Gastroenterol. 27:17-28, 1992.
32. Rio, M., Chenard, M. P., Wolf, C., Marcellin, L., Tomasetto, C., Lathe, R., Bellocq, J.P., and Chambon, P. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract. Gastroenterology 100:375-9, 1991.
33. Alison, M.R., Chinery, R., Poulsom, R., Ashwood, P., Longcroft, J., and Wright, N.A. Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor, and transforming growth factor alpha mRNAs in rat stomach. J. Pathol. 175:405-414, 1995.
34. Jørgensen, K.D., Diamant, B., Jørgensen, K.H., and Thim, L. Pancreatic spasmolytic polypeptide (PSP): III. Pharmacology of a new porcine pancreatic polypeptide with spasmolytic and gastric acid secretion inhibitory effects. Regul. Pept. 3:231-43, 1982.
35. Playford, R.J., Marchbank, T., Chinery, R., Evison, R., Pignatelli, M., Boulton, R.A., Thim, L., and Hanby, A.M. Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. Gastroenterology. 108:08-116, 1995.
36. Jørgensen, K H., Thim, L., and Jacobsen, H. E. Pancreatic spasmolytic polypeptide (PSP): I. Preparation and initial chemical characterization of a new polypeptide from porcine pancreas. Regul. Pept. 3:207-19, 1982.
37. Hoosein, N.M., Thim, L., Jørgensen, K.H., and Brattain, M.G. Growth stimulatory effect of pancreatic spasmolytic polypeptide on cultured colon and breast tumor cells. FEBS Lett. 247:303-6, 1989.
38. Frandsen, E.K., Jørgensen, K.H., and Thim, L. Receptor binding of pancreatic spasmolytic polypeptide (PSP) in rat intestinal mucosal cell membranes inhibits the adenylate cyclase activity. Regul. Pept. 16:291-7, 1986.
39. Frandsen, E.K. Receptor binding of pancreatic spasmolytic polypeptide in intestinal mucosal cells and membranes. Regul Pept. 20:45-52, 1988.
40. Otto, W.R., Rao, J., Cox, H.M., Kotzian, E., Lee, C., Goodlad, R.A., Lane, A., Gorman, M., Freemont, P.A., Hansen, H.F., Pappin, D., and Wright, N.A. Effects of pancreatic spasmolytic polypeptide (PSP) on epithelial cell function. Eur. J. Biochem. 235:64-72, 1996.
41. Otto, W R., Rao, J., Kotzian, E., Cox, H., Lee, C., Goodlad, R.A., Lane, A., Pappin, D., Hansen, H., Freemont, P., Gorman, M., and Wright, N.A. Glutathione dependence of pancreatic spasmolytic polypeptide for cell growth effects in vitro. J. Pathol. 172(Suppl):Abstract 67, 1993.
42. Chinery, R., Poulsom, R., Elia, G., Hanby, A.M., and Wright, N.A. Expression and purification of a trefoil peptide motif in a ß-galactosidase fusion protein and its use to search for trefoil binding sites. Eur. J. Biochem. 212:557-563, 1993.
43. Chinery, R., Bates, P.A., De, A., and Freemont, P.S. Characterisation of the single copy trefoil peptides intestinal trefoil factor and pS2 and their ability to form covalent dimers. FEBS Letters. 357:50-54, 1995.
44. Thim, L., Norris, K., Norris, F., Nielsen, P., Bjørn, S.E., Christensen, M., and Petersen, J. Purification and characterisation of the trefoil peptide human spasmolytic polypeptide (hSP) produced in yeast. FEBS Letts. 318:345-352, 1993.
45. Thim, L., Woldike, H.F., Nielsen, P.F., Christensen, M., Lynch-Devaney, K., and Podolsky, D. K. Characterization of human and rat intestinal trefoil factor produced in yeast. Biochemistry. 34:4757-4764, 1995.
46. Babyatsky, M.W., Thim, L., and Podolsky, D.K. Trefoil peptides protect against ethanol and indomethacin induced gastric injury in rats. Gastroenterology 106:A43, 1994.
47. Prud'homme, J.F., Jolivet, A., Pichon, M.F., Savouret, J.F., and Milgrom, E. Monoclonal antibodies against native and denatured forms of estrogen-induced breast cancer protein (BCEI/pS2) obtained by expression in Escherichia coli. Cancer Res. 50:2390-6, 1990.
48. Miyashita, S., Nomoto, H., Konishi, H., and Hayashi, K. Estimation of pS2 protein level in human body fluids by a sensitive two-site enzyme immunoassay. Clinica. Chimica. Acta. 228: 1-81, 1994.
49. Chadwick, M.P., May, F.E.B., and Westley, B.R. Production and comparison of mature single-domain "trefoil" peptides pNR-2/pS2 Cys58 and pNR-2/pS2 Ser 58. Biochem. J. 308:1001-1007, 1995.
50. Tomasetto, C., Wolf, C., Rio, M., Mehtali, M., LeMeur, M., Gerlinger, P., Chambon, P., and Lathe, R. Breast cancer protein pS2 synthesis in mammary gland of transgenic mice and secretion into milk. Mol. Endocrinol. 3:1579-84, 1989.
51. Chinery, R. and Playford, R. Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indomethacin-induced gastric damage in the rat. Clinical Science. 88:401-403, 1995.
52. Kida, N., Yoshimura, T., Mori, K., and Hayashi, K. Hormonal regulation of synthesis and secretion of pS2 protein relevant to growth of human breast cancer cells (MCF-7). Cancer Res. 49: 3494-8, 1989.
53. Chinery, R. and Cox, H. M. Immunoprecipitation and characterization of a binding protein specific for the peptide Intestinal Trefoil Factor. Peptides. 16:749-755, 1995.
54. Nunez, A.M., Berry, M., Imler, J.L., and Chambon, P. The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein. EMBO J. 8:823-9, 1989.
55. Cavailles, V., Garcia, M., and Rochefort, H. Regulation of cathepsin-D and pS2 gene expression by growth factors in MCF7 human breast cancer cells. Mol. Endocrinol. 3: 552-8, 1989.
56. Miyashita, S., Hirota, M., Yamamoto, T., Shiroyama, C., Furukawa, Y., and Hayashi, K. Effect of basic fibroblast growth factor on synthesis/secretion of pS2 protein by human breast cancer cells (MCF-7). Eur. J. Biochem. 225:1041-1046, 1994.
57. Cox, H. M., Chinery, R., and Wright, N.A. An epithelial ion transport role for intestinal trefoil factor but not for pancreatic spasmolytic polypeptide. Regul. Pept. 47:90, 1993.
58. Chinery, R. and Cox, H.M. Modulation of epidermal growth factor effects on epithelial ion transport by intestinal trefoil factor. Br. J. Pharmacol. 115:77-80, 1995.
59. Gajhede, M., Petersen, T. N., Henriksen, A., Petersen, J. F. W., Dauter, Z., Wilson, K. S., and Thim, L. Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides. Structure. 1:253-262, 1993.
60. Kindon, H., Pothoulakis, C., Thim, L., Lynch-Devaney, K., and Podolsky, D.K. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology 109:516-523, 1995.