Comparative efficacy of the Schistosoma mansoni nucleic acid vaccine, Sm23, following microseeding or gene gun delivery

Parasite Immunology

Volumn 24, Issue 4, 2002, Pages 179-187

  Da'dara, Akram A ^a   Skelly, Patrick J ^a   Fatakdawala, Mufaddal ^a   Visovatti, Scott ^b   Eriksson, Elof ^b   Harn, Donald A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

DNA vaccine; Gene gun; Microseeding; Schistosoma mansoni; Sm23

Indexed keywords

ALLOANTIBODY; COMPLEMENTARY DNA; DNA VACCINE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; IMMUNOGLOBULIN G3; INTERLEUKIN 12; INTERLEUKIN 4; PLASMID DNA; PROTEIN SM23; SCHISTOSOMA VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GENE CONSTRUCT; GENE GUN; GENE TARGETING; GENETIC CODE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; INTERMETHOD COMPARISON; MICROSEEDING; MOUSE; NONHUMAN; PARASITOSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROVOCATION TEST; SCHISTOSOMA MANSONI; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; VACCINATION;

ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; BIOLISTICS; IMMUNIZATION; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; INTERLEUKIN-12; INTERLEUKIN-4; LIFE CYCLE STAGES; MICE; MICE, INBRED BALB C; SCHISTOSOMA MANSONI; VACCINES, DNA;

ANIMALIA; SCHISTOSOMA; SCHISTOSOMA MANSONI; TREMATODA;

EID: 0036091894     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2002.00453.x     Document Type: Article

References (56)

1. Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity
2. DNA vaccines: Technology and application as anti-parasite and anti-microbial agents
3. DNA vaccines: A key for inducing long-term cellular immunity
4. Immune responses to DNA vaccines
5. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
6. Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids
7. Protective CD4+ and CD8+ T cells against influenza virus induced by vaccination with nucleoprotein DNA
8. Induction of a TH1 type cellular immune response to the human immunodeficiency type 1 virus by in vivo DNA inoculation
9. Immunization with plasmid DNA encoding the integral membrane protein, Sm23, elicits a protective immune response against schistosome infection in mice
10. Schistosomiasis vaccine development: Approaches and prospects
11. Post-transmission schistosomiasis: A new agenda
12. Schistosomiasis vaccine development: Progress and prospects
13. Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum
14. Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection
15. Vaccine strategies against schistosomiasis: From concepts to clinical trials
16. A vaccine against Asian schistosomiasis: The story unfolds
17. Schistosoma mansoni: Detection by monoclonal antibody of a 22 000-dalton surface membrane antigen which may be blocked by host molecules on lung stage parasites
18. T and B cell epitope mapping of SM23, an integral membrane protein of Schistosoma mansoni
19. Synthetic peptide vaccines for schistosomiasis
20. Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases
21. Cytokines and costimulatory molecules as genetic adjuvants
22. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens
23. Chemokine gene adjuvants can modulate immune responses induced by DNA vaccines
24. Gene transfer in wound healing
25. In vivo gene transfer to skin and wound by microseeding
26. DNA-based immunization by in vivo transfection of dendritic cells
27. Schistosoma mansoni: Anti-egg monoclonal antibodies protect against cercarial challenge in vivo
28. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
29. Is IgG2a a good Th1 marker in mice?
30. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses
31. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery
32. DNA vaccines
33. Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates
34. CpG motifs in bacterial DNA trigger direct B-cell activation
35. Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides
36. CpG DNA as a Th1 trigger
37. Activation of the innate immune system by CpG oligodeoxynucleotides: Immunoprotective activity and safety
38. CpG motifs as immune adjuvants
39. CpG DNA augments the immunogenicity of plasmid DNA vaccines
40. CpG DNA and LPS induce distinct patterns of activation in human monocytes
41. A Toll-like receptor recognizes bacterial DNA
42. Dendritic cell discoveries provide new insight into the cellular immunobiology of DNA vaccines
43. Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency
44. T cell regulation of IgG subclass antibody production in response to T-independent antigens
45. IgG3 is the major source of cryoglobulins in mice
46. Intermolecular cooperativity: A clue to why mice have IgG3?
47. Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants
48. IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+ T cell-mediated protective immunity against herpes simplex virus-2 challenge
49. IL-12 as an adjuvant for cell-mediated immunity
50. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
51. Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
52. Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1
53. Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes
54. Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement
55. Activity and safety of DNA plasmids encoding IL-4 and IFN gamma
56. Identification of the mouse IgG3 receptor: Implications for antibody effector function at the interface between innate and adaptive immunity