Isolation (from a basal cell carcinoma) of a functionally distinct fibroblast-like cell type that overexpresses Ptch

Journal of Investigative Dermatology

Volumn 118, Issue 5, 2002, Pages 859-865

  Dicker, Anthony J ^a   Serewko, Magdalena M ^a   Russell, Terry ^a   Dahler, Alison L ^a   Saunders, Nicholas A ^a   Rothnagel, Joseph A ^a   Strutton, Geoff M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Epithelial mesenchymal transition; Epithelium; Skin cancer

Indexed keywords

CYTOKERATIN; DNA; GAMMA INTERFERON; PROTEIN; PROTEIN PATCHED; PROTEIN PATCHED 2; TUMOR MARKER; UNCLASSIFIED DRUG; VIMENTIN;

ARTICLE; BASAL CELL CARCINOMA; CARCINOGENESIS; CELL ASSAY; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CELL POPULATION; CELL STIMULATION; CELL TYPE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SYNTHESIS; EPITHELIUM CELL; FIBROBLAST; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CELL;

EID: 0036091144     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01739.x     Document Type: Article

References (54)

1. Growth characteristics and differentiation of basal cell carcinoma in vitro - Immunohistochemical, gel electrophoretic, and ultrastructural analysis
2. Immunohistochemical characterization of the differentiation state of basal cell carcinomas with special interest for infiltrating relapsing tumors
3. Homeobox 1.3 expression: Induction by retinoic acid in human bronchial fibroblasts
4. Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts
5. Regression of basal cell carcinoma by intralesional interferon-alpha treatment is mediated by CD95 (Apo-1/Fas)-CD95 ligand-induced suicide
6. Incidence rates of skin cancer in Townsville, Australia
7. TGF beta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
8. Keratinocyte growth arrest is associated with activation of a transcriptional repressor element in the human cdk1 promoter
9. Suppression of keratinocyte growth and differentiation by transforming growth factor-b1 are mediated by different signaling pathways
10. Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1)
11. E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes
12. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog
13. Different intermediate-sized filaments distinguished by immunofluorescence microscopy
14. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
15. Incidence of non-melanocytic skin cancer treated in Australia
16. Basal cell carcinomas in mice overexpressing Gli2 in skin
17. Nodular basal cell carcinoma in vivo vs in vitro. Establishment of pure cell cultures, cytomorphologic characteristics, ultrastructure, immunophenotype, biosynthetic activities, and generation of antisera
18. A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
19. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
20. Patched overexpression alters wing disc size and pattern: Transcriptional and post-transcriptional effects on hedgehog targets
21. Human homolog of patched, a candidate gene for the basal cell nevus syndrome
22. New players and puzzles in the hedgehog signalling pathway
23. Hemidesmosomes, collagen VII, and intermediate filaments in basal cell carcinoma
24. E2F as a regulator of keratinocyte proliferation: Implications for skin tumor development
25. Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin
26. Wnt signaling maintains the hair-inducing activity of the dermal papilla
27. Expression of interferon-gamma receptors and interferon-gamma-induced up-regulation of intercellular adhesion molecule-1 in basal cell carcinoma; decreased expression of IFN-gamma R and shedding of ICAM-1 as a means to escape immune surveilance
28. Keratin expression in basal cell carcinomas
29. Role of hair papilla cells on induction and regeneration processes of hair follicles
30. p53 gene mutations in human epithelial skin cancers
31. Basal cell carcinoma in mice overexpressing sonic hedgehog
32. Epithelial-stromal interactions in basal cell cancer: The PDGF system
33. Cytochrome P450, CYP26, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible
34. p53 mutations in basal cell carcinomas
35. Effect of substratum and retinoids upon the mucosecretory differentiation of airway epithelial cells in vitro
36. Regulation of transglutaminase type I expression in squamous differentiating rabbit tracheal epithelial cells and human epidermal keratinocytes. Effects of retinoic acid and phorbol esters
37. Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells
38. Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1
39. In situ analysis of transforming growth factors-β (TGF-β1, TGF-β2, TGF-β3) and TGF-β type II receptor expression in basal cell carcinomas
40. Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation. Implications for tumor development and progression
41. Gene expression in rat dermal papilla cells: Analysis of 2529 ESTS
42. bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas
43. Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32
44. Differential expression of laminin isoforms and beta 4 integrin epitopes in the basement membrane zone of normal human skin and basal cell carcinomas
45. Transforming growth factor-beta distribution in basal cell carcinomas: Relationship to proliferation index
46. c-jun and junB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin
47. Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma
48. Transforming growth factor-beta and bcl-2 distribution patterns distinguish trichoepithelioma from basal cell carcinoma
49. Post-transcriptional regulation of the Gli1 oncogene by the expression of alternative 5′ untranslated regions
50. Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
51. PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas
52. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers