Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K+ channels expressed in a mammalian cell line

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 1, 2000, Pages 339-346

  Katayama, Yusuke ^a,b   Fujita, Akikazu ^a,c   Ohe, Tohru ^b   Findlay, Ian ^d   Kurachi, Yoshihisa ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c Osaka Prefecture University   (Japan)

^d UNIVERSITÉ DE TOURS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PIPERANOMETOZINE; POTASSIUM CHANNEL;

ARTICLE; CELL MEMBRANE DEPOLARIZATION; CHANNEL GATING; CONCENTRATION RESPONSE; DRUG BINDING; EMBRYO; GENE EXPRESSION; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; PRIORITY JOURNAL;

ACTION POTENTIALS; CATION TRANSPORT PROTEINS; CELL LINE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART; HUMANS; PHOSPHODIESTERASE INHIBITORS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; QUINOLINES; RECOMBINANT PROTEINS; TIME FACTORS; TRANS-ACTIVATORS;

EID: 0033931963     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97:175-187.
2. Asanoi H, Sasayama S, Kameyama T, Ishizaka S and Iuch K (1989) Sustained inotropic effcts of a new cardiotonic agent, OPC-8212, in patients with chronic heart failure. Clin Cardiol 12:133-138.
3. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M and Romey G (1996) K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature (Lond) 384:78-80.
4. + current in cardiac myocytes by dofetilide. J Pharmacol Exp Ther 262:809-817.
5. Feldman AM, Becker LC, Llewellyn MP and Baughmann KI (1988) Evaluation of a new inotropic agent, OPC-8212, in patients with dilated cardiomyopathy and heart failure. Am Heart J 116:771-777.
6. Feldman AM, Bristow MR, Parmley WW, Carson PE, Pepine CJ, Gilbert EM, Strobeck JE, Hendrix GH, Powers ER, Bain RP and White BG, for the Vesnarinone Study Group (1993) Effects of vesnarinone on morbidity and mortality in patients with heart failure. Vesnarinone study group. N Engl J Med 329:149-155.
7. Iijima T and Taira N (1987) Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart. J Pharmacol Exp Ther 240:657-662.
8. + current in human ventricular myocytes. Circ Res 78:689-696.
9. Miyamoto G and Sasabe H (1984) Pharmacokinetics od a positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212), in the rat, rabbit, beagle dog and rhesus monkey. Arzneim-Forsch 34:394-402.
10. Murai T, Kakizuka T, Takumi H, Ohkubo H and Nakanishi S (1989) Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity. Biochem Biophys Res Commun 161:176-181.
11. Rapundalo ST, Lathrop DA, Harrison SA, Beavo JA and Schwartz A (1988) Cyclic AMP-dependent and cyclic AMP-independent actions of a novel cardiotonic agent, OPC-8212. Naunyn-Schmiedeberg's Arch Pharmacol 338:692-698.
12. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL and Keating MT (1996) Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature (Lond) 384:80-83.
13. Kr potassium channel. Cell 81:299-307.
14. + current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96:195-215.
15. + current is composed of two currents in guinea pig atrial cells. Am J Physiol 260:H393-H399.
16. Shimizu T, Osumi T, Niimi K and Nakagawa K (1984) Physico-chemical properties and stabilities of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212). Arzneim-Forsch 34:334-341.
17. Smith PL, Baukrowitz T and Yellen G (1996) The inward rectification mechanism of the HERG cardiac potassium channel. Nature (Lond) 379:833-836.
18. Snyders DJ and Chaudhary A (1996) High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol 49:949-955.
19. + channel. Open-channel block by methanesulfonanilides. Circ Res 78:499-503.
20. Taira N, Endoh M, Iijima T, Satoh K, Yanagisawa T, Yamashita S, Maruyama M, Kawada M, Morita T and Wada Y (1984) Mode and mechanism of action of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212), a novel positive inotropic drug, on the dog heart. Arzneim-Forsch 34:347-355.
21. + current. Circulation 96; 3696-3703.
22. Trudeau MC, Warmke JW, Ganetzky B and Robertson GA (1995) HERG, a human inward rectifier in the voltage-gated potassium channel family. Science (Wash DC) 269:92-95.
23. Wang Z, Fermini B and Nattel S (1994) Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc Res 28:1540-1546.
24. Yamashita S, Hosokawa T, Kojima M, Mori T and Yabuuchi Y (1984) In vitro and in vivo studies of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212), a novel positive inotropic drug, in various animals. Arzneim-Forsch 34:342-346.
25. Yang WP, Levesque PC, Little WA, Conder ML, Shalaby FY and Blanar MA (1997) KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci USA 94:4017-4021.