Molecular chaperones and the process of cellular immortalization in vitro

Biogerontology

Volumn 3, Issue 3, 2002, Pages 183-185

  Kroll J ^a,b  

^a BLEKINGE HOSPITAL   (Sweden)

^b NONE   (Denmark)

Author keywords

Cell immortalization; Life span; Molecular chaperones

Indexed keywords

CHAPERONE; VIRUS T ANTIGEN;

ARTICLE; CELL DIVISION; CELL IMMORTALIZATION; CONTROLLED STUDY; EVOLUTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIFESPAN; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; SIMIAN VIRUS 40; SPECIES;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL ADHESION; DNA-BINDING PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE PROTEINS; MOLECULAR CHAPERONES; TELOMERASE;

EID: 0036089220     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015603410174     Document Type: Article

References (32)

1. Polyomavirus T antigens: Molecular chaperones for multiprotein complexes
2. Hsp70 (DnaK) - An evolution facilitator?
3. Use of monoclonal antibodies as probes of simian virus 40 T antigen ATPase activity
4. Hormesis: A stress response in cells exposed to low levels of heavy metals
5. The physiologic, neurologic, and behavioral effects of caloric restriction related to aging, disease, and environmental factors
6. Stable association of hsp90 and p23, but not hsp70, with active human telomerase
7. Chaperones in cell cycle regulation and mitogenic signal transduction: A review
8. Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2
9. The ATPase module and the process of cellular immortalization
10. Identification and characterization of a heat shock protein 70 family member in channel catfish (Ictalurus punctatus)
11. Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation
12. Induction of novel Grp75 isoforms by 2-deoxyglucose in human and murine fibroblasts
13. The Werner syndrome. A model for the study of human aging
14. Expression of molecular chaperones and vesicle transport proteins in differentiating oligodendrocytes
15. The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes
16. Characterization of epithelial phenotypes in mortal and immortal human breast cells
17. Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen
18. Biogerontology: The next step
19. Immortalized cells with no detectable telomerase activity. A review
20. Maintenance of cellular proliferation by adenovirus early region 1A in fibroblasts conditionally immortalized by using simian virus 40 large T antigen requires conserved region 1
21. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
22. Molecular chaperones and the aging process
23. The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism
24. Expression of cyclophilin and HSC70 mRNAs in the brain is associated with the survival rate in male and female senescence accelerated mouse (SAM) P8 and R1 strains
25. Two regions of simian virus 40 large T-antigen independently extend the life span of primary C57BL/6 mouse embryo fibroblasts and cooperate in immortalization
26. Transgenic methods for increasing Drosophila life span
27. A conserved HPD sequence of the J-domain is necessary for YDJ1 stimulation of Hsp70 ATPase activity at a site distinct from substrate binding
28. Functional similarity between HPV16E7, SV40 large T and adenovirus E1a proteins
29. A relationship between thermotolerance and longevity in Caenorhabditis elegans
30. Chromosomal markers of immortalization in human breast epithelium
31. A phenotypically and karyotypically stable human thyroid epithelial line conditionally immortalized by SV40 large T antigen
32. Stress protein expression in primary and immortalized cultures of human thyroid cells: A model system for the study of stress proteins in the pathogenesis of autoimmune thyroid disease